ORCID Profile
0000-0002-8139-0084
Current Organisation
Tianjin University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Cold Spring Harbor Laboratory
Date: 16-06-2022
DOI: 10.1101/2022.06.16.22271932
Abstract: There is limited information describing the course and severity of illness in subjects infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant, especially in children. In this population-based cohort study, subjects with Omicron variant infection during the outbreak between January 8 and February 12, 2022 in Tianjin, China were included (n=429). The main outcomes were the distribution of asymptomatic, mild, moderate, and severe patients, and clinical courses including the interval from positive polymerase chain reaction (PCR) test to the onset, aggravation or relief of symptoms, and the interval of reversing positive PCR-test into negative, and length of hospital stay. Of the 429 subjects (113 [26.3%] children 239 [55.7%] female median age, 36 years [IQR 15.0 to 55.0 years]), the proportion (95% CI) of symptomatic subjects on admission was 95.6% (93.2%, 97.2%), including 60.4% (55.7%, 64.9%) mild, 35.0% (30.6%, 39.6%) moderate, and 0.2% (0.0%, 1.3%) severe. Compared with adults, children had lower proportion of moderate Covid-19 (8.8% vs 44.3%). On discharge, 45.9% (41.3%, 50.7%) and 42.2% (37.6%, 46.9%) of the subjects were diagnosed as having experienced mild and moderate Covid-19. The median (IQR) length of hospital stay was 14.0 (12.0, 15.0) days. The median interval of reversing positive PCR-test into negative was 12.0 (10.0, 13.0) days. Symptomatic and moderate Covid-19 in Omicron infections was common in adults and children, recovery from Omicron infections took around 2 weeks of time. The SARS-CoV-2 Omicron infection in this study was not as mild as previously suggested. Previous studies have demonstrated that Omicron patients were more likely to be mild, less hospitalized, less severe disease, and of lower mortality. However, there is limited information describing the course and severity of illness in subjects infected by the Omicron variant, especially in children. This study reveals that the prevalence of symptomatic and moderate Covid-19 in Omicron infections was considerably high for children and adults in China. In this population based cohort study of 113 children and 316 adults with Omicron variant infection contracted during the outbreak in Tianjin, China, 95.6% of the subjects were symptomatic on admission. Although children had significantly lower proportions of moderate Covid-19 on admission compared to adults (8.8% vs 44.3%), almost one of ten infected children suffered from moderate COVID-19. This study expands our understanding of the course and illness severity of the SARS-CoV-2 Omicron infections, especially in children. Awareness and appropriate control policies are needed to reduce moderate illnesses by the Omicron infections.
Publisher: S. Karger AG
Date: 2014
DOI: 10.1159/000362694
Abstract: b i Objective: /i /b To investigate the cross-sectional association between food intake and overweight in children. b i Methods: /i /b Height and weight were measured in 2,565 school-aged children. Intakes of 11 food groups were categorized (low, medium and high) using specific tertile cutoffs. Multivariate energy partition models were applied. Adjustment included energy intake from other food groups, city, family income, parental education and ‘screen' time. Possible underreporters were identified and used in sensitivity analyses. b i Results: /i /b Compared to low intake, high intakes of meat, fish, beverages and bakery products were associated with greater BMI z-scores [β (95% CI) = 0.32 (0.21, 0.42), 0.13 (0.03, 0.24), 0.23 (0.11, 0.35) and 0.10 (-0.01, 0.20)] and increased risk of being overweight [odds ratio (OR) (95% CI) = 2.08 (1.58, 2.73), 1.39 (1.08, 1.80), 1.36 (1.01, 1.84) and 1.62 (1.24, 2.11)]. Conversely, medium and high intakes of confectionery were associated with smaller BMI z-scores [β = -0.18 (-0.28, -0.07) and -0.22 (-0.33, -0.12)] and decreased risk of being overweight [OR = 0.64 (0.50, 0.83) and 0.53 (0.40, 0.68)]. These associations were robust to sensitivity analyses. b i Conclusions: /i /b Intakes of meat, fish, beverages and bakery products correlate with body weight status.
Publisher: Springer Science and Business Media LLC
Date: 24-04-2013
DOI: 10.1038/EJCN.2013.80
Publisher: Springer Science and Business Media LLC
Date: 21-05-2014
DOI: 10.1038/EJCN.2014.92
Publisher: Elsevier BV
Date: 05-2014
DOI: 10.1016/J.JPEDS.2013.12.044
Abstract: To investigate whether birth by cesarean delivery rather than vaginal delivery is a risk factor for later childhood obesity. Healthy, full-term infants were recruited. Overweight and obesity were defined using measured weight and height according to World Health Organization reference data. Associations between cesarean delivery and being overweight or obese were investigated at age 2, 6, and 10 years (n = 1734, 1244, and 1170, respectively) by multivariate logistic regression models adjusted for socioeconomic status, child characteristics, and maternal prepregnancy characteristics. Mothers who gave birth by cesarean delivery (∼17%) had a higher mean prepregnancy body mass index (23.7 kg/m(2) vs 22.5 kg/m(2)), greater mean gestational weight gain (15.3 kg vs 14.5 kg), and shorter mean duration of exclusive breastfeeding (3.4 months vs 3.8 months) compared with those who delivered vaginally. The proportion of obese children was greater in the cesarean delivery group compared with the vaginal delivery group at age 2 years (13.6% vs 8.3%), but not at older ages. Regression analyses revealed a greater likelihood of obesity at age 2 years in the cesarean delivery group compared with the vaginal delivery group at age 2 years (aOR, 1.68 95% CI, 1.10-2.58), but not at age 6 years (aOR, 1.49 95% CI, 0.55-4.05) or age 10 years (aOR, 1.16 95% CI, 0.59-2.29). Cesarean delivery may increase the risk of obesity in early childhood. Our results do not support the hypothesis that an increasing rate of cesarean delivery contributes to obesity in childhood.
Location: Germany
No related grants have been discovered for Zhengcun Pei.