ORCID Profile
0000-0001-9439-5573
Current Organisations
Ora Inc
,
University of Manchester
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 11-02-2021
DOI: 10.1111/AOS.14782
Abstract: To explore the presence of microvascular endothelial dysfunction as a measure for early cardiovascular disease in in iduals diagnosed with dry eye disease (DED) as compared to age‐matched normal controls. Systemic blood pressure, Body Mass Index, intraocular pressure, blood levels of glucose (GLUC), triglycerides, cholesterol (CHOL), high‐density lipoprotein cholesterol (HDL‐C), and low‐density lipoprotein cholesterol (LDL‐C)] as well as retinal and peripheral microvascular function were assessed in twenty‐five 35–50 year olds with diagnosed with DEDa (using the TFOS DEWS II criteria) and 25 age and sex‐matched controls. After controlling all the influential covariates, in iduals diagnosed with DED exhibited significant lower retinal artery baseline (p = 0.027), artery maximum diameter (p = 0.027), minimum constriction (p = 0.039) and dilation litude (p = 0.029) than controls. In addition, the time to reach the vein maximum diameter was significantly longer in the DED patients than in normal controls (p = 0.0052). Only in in iduals diagnosed with DED, artery maximum constriction correlated statistically significantly and positively with HDL‐C blood levels (p = 0.006). Similarly, artery slope AD correlated positively with T‐CHOL and LDL‐C (p = 0.006 & 0.011 respectively). Additionally, artery baseline diameter and maximum constriction were significantly and negatively correlated to T‐CHOL/HDL‐C ratio (p = 0.032 and p = 0.013 respectively) in DED in iduals only. In iduals with positive diagnosis of DED exhibit abnormal retinal microvascular function and possible higher risk for CVD.
Publisher: MDPI AG
Date: 14-06-2022
DOI: 10.3390/NU14122462
Abstract: The aim of the present research was to assess the effect of bariatric surgery-induced weight loss on the tear film and ocular surface of patients with obesity. A total of 29 participants with obesity (aged 47.2 ± 10.1 years, 8 male) were measured at baseline and followed up one year after Roux-en-Y gastric bypass (RYGB) surgery. General anthropometric data, as well as serum lipid markers of cholesterol, were assessed in all in iduals. Bilateral anterior eye measurements of tear meniscus height (TMH), non-invasive tear breakup time, bulbar and limbal redness and infrared meibography were captured using the Keratograph K5M (Oculus) and ocular surface damage was evaluated using fluorescein sodium and lissamine green staining. Bariatric surgery resulted in significant loss of weight (body mass index p 0.001) and an improvement in the blood lipid profile (p 0.01) in all participants. However, there were no statistically significant differences between the baseline and one-year follow-up for any of the measured clinical ocular surface and tear film variables (all p 0.05). Although there were trends for a reduced TMH and a decrease in meibomian gland dropout after bariatric surgery, these differences were also insignificant (p 0.05). In conclusion, weight reduction through bariatric surgery did not have an effect on the tear film or ocular surface in unselected patients with obesity.
Location: Romania
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Doina Gherghel.