ORCID Profile
0000-0003-0896-267X
Current Organisations
University of Cambridge
,
Imperial College London
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Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0LC00446D
Abstract: Microchannels created in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogels have the potential to prevent dry-eye disease by facilitating tear exchange. Biosensors are further demonstrated for wearable biosensing applications.
Publisher: Wiley
Date: 11-06-2019
Abstract: Contact lenses are ocular prosthetic devices used by over 150 million people worldwide. Primary applications of contact lenses include vision correction, therapeutics, and cosmetics. Contact lens materials have significantly evolved over time to minimize adverse effects associated with contact lens wearing, to maintain a regular corneal metabolism, and to preserve tear film stability. This article encompasses contact lens technology, including materials, chemical and physical properties, manufacturing processes, microbial contamination, and ocular complications. The function and the composition of the tear fluid are discussed to assess its potential as a diagnostic media. The regulatory standards of contact lens devices with regard to biocompatibility and contact lens market are presented. Future prospects in contact lens technology are evaluated, with particular interest given to theranostic applications for in situ continuous monitoring the ocular physiology.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7RA04131D
Abstract: A corner cube retroreflector (CCR) consists of three perpendicular flat surfaces and reflects the incident light back to its source.
Publisher: Elsevier BV
Date: 08-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0LC00438C
Abstract: Paper microfluidic sensors were integrated into laser-inscribed contact lenses to provide an in situ platform for tear analysis with smartphone readouts.
Publisher: Informa UK Limited
Date: 16-12-2015
Publisher: Wiley
Date: 12-11-2022
Abstract: Contact lenses can be functionalized to offer advanced capabilities transcending their primary applications in vision correction and cosmetics. Herein, 40 and 60 nm spherical silver nanoparticles (SNPs) are integrated within poly(2‐hydroxyethyl methacrylate) (pHEMA) contact lenses toward fabrication of SNP‐loaded contact lenses with excellent optical and material properties as wearables for blue‐yellow color vision deficiency (CVD) patients. The morphology and optical properties of the SNPs are characterized prepolymerization using the transmission electron microscopy (TEM) and an optical spectrophotometer. Then, the transmission spectra of the SNP‐loaded contact lenses at different concentrations along with the wettability and water content are measured, to demonstrate the effect of NPs’ addition on the lenses’ optical and material characteristics. Results indicate that the transmission spectra of SNP‐loaded contact lenses, with optimum concentrations, filter out problematic wavelengths of visible light (485–495 nm), which will facilitate better color distinction for blue‐yellow CVD patients. The contact lenses’ optical properties are analogous to the commercial colorblind glasses, indicating their effectiveness as color filtering wearables. Finally, the cytobiocompatability analysis of the contact lenses to RAW 264.7 culture of cells shows that they are biocompatible, and the cell viability remains higher than 75% after 24 h in contact with the lenses.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6LC01450J
Abstract: This article describes a paper-based microfluidic system that quantifies the concentrations of tear electrolytes using a smartphone-based reader.
Publisher: American Chemical Society (ACS)
Date: 07-10-2021
Publisher: AIP Publishing
Date: 16-03-2016
DOI: 10.1063/1.4944318
Abstract: Periodic highly dense multi-wall carbon nanotube (MWCNT) arrays can act as photonic materials exhibiting band gaps in the visible regime and beyond terahertz range. MWCNT arrays in square arrangement for nanoscale lattice constants can be configured as a microcavity with predictable resonance frequencies. Here, computational analyses of compact square microcavities (≈0.8 × 0.8 μm2) in MWCNT arrays were demonstrated to obtain enhanced quality factors (≈170–180) and narrow-band resonance peaks. Cavity resonances were rationally designed and optimized (nanotube geometry and cavity size) with finite element method. Series (1 × 2 and 1 × 3) and parallel (2 × 1 and 3 × 1) combinations of microcavities were modeled and resonance modes were analyzed. Higher order MWCNT microcavities showed enhanced resonance modes, which were red shifted with increasing Q-factors. Parallel microcavity geometries were also optimized to obtain narrow-band tunable filtering in low-loss communication windows (810, 1336, and 1558 nm). Compact series and parallel MWCNT microcavity arrays may have applications in optical filters and miniaturized optical communication devices.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9RA00601J
Abstract: Temperature variation is a ubiquitous medical sign to monitor ocular conditions including dry eye disease (DED), glaucoma, carotid artery stenosis, diabetic retinopathy, and vascular neuritis.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA11538A
Abstract: A refractive index (RI) based corrosion sensor that could measure the oxidation of iron metal to iron-oxide was numerically investigated with a finite element method.
Publisher: Wiley
Date: 19-08-2021
Abstract: Contact lens sensing platforms have drawn interest in the last decade for the possibility of providing a sterile, fully integrated ocular screening technology. However, designing scalable and rapid contact lens processing methods while keeping a high resolution is still an unsolved challenge. In this article, femtosecond laser writing is employed as a rapid and precise procedure to engrave microfluidic networks into commercial contact lenses. Functional microfluidic components such as flow valves, resistors, multi‐inlet geometries, and splitters are produced using a bespoke seven‐axis femtosecond laser system, yielding a resolution of 80 µm. The ablation process and the tear flow within microfluidic structures is evaluated both experimentally and computationally using finite element modeling. Flow velocity drops of the 8.3%, 20.8%, and 29% were observed in valves with enlargements of the 100%, 200%, and 300%, respectively. Resistors yielded flow rate drops of 20.8%, 33%, and 50% in the small, medium, and large configurations, respectively. Two applications were introduced, namely a tear volume sensor and a tear uric acid sensor (sensitivity 16 mg L −1 ), which are both painless alternatives to current methods and provide reduced contamination risks of tear s les.
Publisher: Elsevier BV
Date: 05-2016
Publisher: Wiley
Date: 28-12-2018
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Ali K. Yetisen.