ORCID Profile
0000-0002-8512-105X
Current Organisation
University of Hail
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Publisher: Oxford University Press (OUP)
Date: 30-07-2020
Publisher: Springer Science and Business Media LLC
Date: 20-02-2019
DOI: 10.1038/S41598-019-38864-5
Abstract: Toll-like receptor 7 (TLR7) is a pattern recognition receptor that recognizes viral RNA following endocytosis of the virus and initiates a powerful immune response characterized by Type I IFN production and pro-inflammatory cytokine production. Despite this immune response, the virus causes very significant pathology, which may be inflammation-dependent. In the present study, we examined the effect of intranasal delivery of the TLR7 agonist, imiquimod or its topical formulation Aldara, on the inflammation and pathogenesis caused by IAV infection. In mice, daily intranasal delivery of imiquimod prevented peak viral replication, bodyweight loss, airway and pulmonary inflammation, and lung neutrophils. Imiquimod treatment also resulted in a significant reduction in pro-inflammatory neutrophil chemotactic cytokines and prevented the increase in viral-induced lung dysfunction. Various antibody isotypes (IgG1, IgG2a, total IgG, IgE and IgM), which were increased in the BALF following influenza A virus infection, were further increased with imiquimod. While epicutaneous application of Aldara had a significant effect on body weight, it did not reduce neutrophil and eosinophil airway infiltration indicating less effective drug delivery for this formulation. We concluded that intranasal imiquimod facilitates a more effective immune response, which can limit the pathology associated with influenza A virus infection.
Publisher: Informa UK Limited
Date: 21-04-2015
Publisher: Springer International Publishing
Date: 2016
Publisher: Hindawi Limited
Date: 2014
DOI: 10.1155/2014/367173
Abstract: This paper investigates the chaotic behavior and synchronization of two different coupled chaotic FitzHugh-Nagumo (FHN) neurons with unknown parameters under external electrical stimulation (EES). The coupled FHN neurons of different parameters admit unidirectional and bidirectional gap junctions in the medium between them. Dynamical properties, such as the increase in synchronization error as a consequence of the deviation of neuronal parameters for unlike neurons, the effect of difference in coupling strengths caused by the unidirectional gap junctions, and the impact of large time-delay due to separation of neurons, are studied in exploring the behavior of the coupled system. A novel integral-based nonlinear adaptive control scheme, to cope with the infeasibility of the recovery variable, for synchronization of two coupled delayed chaotic FHN neurons of different and unknown parameters under uncertain EES is derived. Further, to guarantee robust synchronization of different neurons against disturbances, the proposed control methodology is modified to achieve the uniformly ultimately bounded synchronization. The parametric estimation errors can be reduced by selecting suitable control parameters. The effectiveness of the proposed control scheme is illustrated via numerical simulations.
Publisher: Springer Science and Business Media LLC
Date: 10-11-2010
DOI: 10.1007/S10827-010-0289-5
Abstract: A three-dimensional model of the reaction-diffusion processes of a neurotransmitter and its ligand receptor in a disk shaped volume is proposed which represents the transmission process of acetylcholine in the synaptic cleft in the neuromuscular junction. The behavior of the reaction-diffusion system is described by a three-dimensional diffusion equation with nonlinear reaction terms due to the rate processes of acetylcholine with the receptor. A new stable and accurate numerical method is used to solve the equations with Neumann boundaries in cylindrical coordinates. The simulation analysis agrees with experimental measurements of end-plate current, and agrees well with the results of the conformational state of the acetylcholine receptor as a function of time and acetylcholine concentration of earlier investigations with a smaller error compared to experiments. Asymmetric emission of acetylcholine in the synaptic cleft and the subsequent effects on open receptor population is simulated. Sensitivity of the open receptor dynamics to the changes in the diffusion parameters and neuromuscular junction volume is investigated. The effects of anisotropic diffusion and non-symmetric emission of transmitter at the presynaptic membrane is simulated.
Publisher: Oxford University Press (OUP)
Date: 08-2018
Publisher: Springer Science and Business Media LLC
Date: 05-10-2015
Publisher: Springer Science and Business Media LLC
Date: 30-06-2021
Publisher: Mary Ann Liebert Inc
Date: 05-2020
Publisher: MDPI AG
Date: 31-05-2022
DOI: 10.3390/MA15113933
Abstract: Nanocomposite multi-layer TiO2/V2O5/TiO2 thin films were prepared via electron-beam evaporation using high-purity targets (TiO2 and V2O5 purity 99.9%) at substrate temperatures of 270 °C (TiO2) and 25 °C (V2O5) under a partial pressure of oxygen of 2 × 10−4 mbar to maintain the stoichiometry. Rutherford backscattering spectrometry was used to confirm the layer structure and the optimal stoichiometry of the thin films, with a particle size of 20 to 40 nm. The thin films showed an optical transmittance of ~78% in the visible region and a reflectance of ~90% in the infrared. A decrease in transmittance was observed due to the greater cumulative thickness of the three layers and multiple reflections at the interface of the layers. The optical bandgap of the TiO2 mono-layer was ~3.49 eV, whereas that of the multi-layer TiO2/V2O5/TiO2 reached ~3.51 eV. The increase in the optical bandgap was due to the inter-diffusion of the layers at an elevated substrate temperature during the deposition. The intrinsic, structural, and morphological features of the TiO2/V2O5/TiO2 thin films suggest their efficient use as a solar water heater system.
Publisher: Springer Science and Business Media LLC
Date: 25-10-2013
Publisher: Elsevier BV
Date: 10-2005
Publisher: Impact Journals, LLC
Date: 14-10-2015
Publisher: IEEE
Date: 12-2007
Publisher: IEEE
Date: 12-2007
Publisher: Informa UK Limited
Date: 22-02-2017
Publisher: Wiley
Date: 28-02-2011
Publisher: Elsevier BV
Date: 2006
Publisher: Oxford University Press (OUP)
Date: 07-2017
Publisher: MDPI AG
Date: 25-03-2022
Abstract: HfO2 and V2O5 as multi-layer thin films are discussed for their potential use as transparent heat mirrors. Multi-layered HfO2/V2O5/HfO2 thin films with a thickness of 100/60/100 nm were prepared via e-beam evaporation on a soda–lime glass substrate. Rutherford backscattering confirmed the multi-layer structure with uniform surface. The as-deposited thin films were annealed at 300 °C and 400 °C, respectively, for 1 h in air. The transmittance of approximately 90% was obtained for all thin films. Due to the relatively low thickness and non-stoichiometry of HfO2, a band gap of approximately 3.25 eV was determined (instead of the theoretical 5.3–5.7 eV). The as-deposited thin films possessed conductivity of approximately 0.2 Ω−1cm−1 and increased to 1 Ω−1cm−1 and 2 Ω−1cm−1 for thin films annealed at 300 and 400 °C, respectively. Due to the unique intrinsic properties of HfO2/V2O5/HfO2 thin films, the results obtained are promising for application as a transparent heat mirror.
Publisher: Elsevier BV
Date: 11-2009
Publisher: Wiley
Date: 02-2014
Publisher: Springer International Publishing
Date: 2011
Publisher: Springer Science and Business Media LLC
Date: 18-01-2014
Publisher: Springer Science and Business Media LLC
Date: 09-03-2018
Publisher: IEEE
Date: 10-2015
Publisher: Springer International Publishing
Date: 2014
Publisher: IEEE
Date: 12-2017
Publisher: Trans Tech Publications, Ltd.
Date: 07-2015
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.1112.481
Abstract: The present paper discusses the challenges both from the technical and non-technical point of views in unlocking alternative resources of lower grade and above ground (urban) metal ores. The lower concentration of the targeted metals and more complex composition of these alternative sources provide challenges in processing and recovering all the valuable metals. There is limited thermodynamic information and the lack of understanding of the behavior of the elements during processing. A comprehensive approach addressing both the technical and non-technical barriers need to be applied for maximizing the resource efficiency and wealth generation. A number of ex les on innovation for processing alternative resources developed in the author’s laboratory are also discussed. These include the electrically enhanced boron impurities removal from metallurgical grade silicon and selective sulfidation to remove chrome spinels (such as chromite FeCr 2 O 4 ) impurities from weathered ilmenite (FeTiO 3 ).
Publisher: Informa UK Limited
Date: 03-2009
Publisher: Springer Science and Business Media LLC
Date: 06-01-2020
Publisher: MDPI AG
Date: 20-05-2022
Abstract: Steel products are coated with Aluminum (Al) and Zinc (Zn) alloys to improve their corrosion properties. Bulk steel products are coated in batches however, steel sheets are coated by a continuous hot-dip galvanizing process. Steel sheets are guided into and out of the molten Al-Zn-Si (AZ) bath with the help of stainless-steel rolls, known as guiding, and sink rolls. These rolls are subjected to excessive surface corrosion with molten AZ bath and, hence, are replaced frequently. The surface deterioration of the immersed rolls has been a long-standing issue in the galvanizing industry. In this study, 316L stainless-steel (SS) rods are immersed in the AZ alloy at 600 °C. The immersion time varied from 1 day to 7 days under the static melt conditions in the iron (Fe)-saturated AZ bath. Microstructural analysis of the immersed SS s les revealed two distinct intermetallic compound (IMC) layers forming between the SS substrate and AZ alloy. The IMC layer 1 (AL-1) formed between the SS substrate and IMC layer 2 (AL-2), growing in thickness from 68 µm to 120 µm within 5 days of immersion. The AL-2, which formed between AL-1 and AZ alloy after 24 h of immersion, then grew in thickness up to 150 µm with an uneven trend. The AL-1 is composed of Fe2Al5 and that of AL-2 is composed of FeAl3 that were predicted by the FactSage thermodynamic analysis. Crack development between AL-1 and AL-2 layers, and disintegration of AL-2 into the AZ bath, are key findings of this study. A drastic hardness increase was observed because the IMC layers produce a hard and brittle sink roll surface.
Publisher: Springer Science and Business Media LLC
Date: 24-02-2018
Publisher: Springer Science and Business Media LLC
Date: 16-11-2018
Publisher: Elsevier BV
Date: 08-2021
Publisher: Oxford University Press (OUP)
Date: 08-2018
Publisher: IEEE
Date: 11-2017
Publisher: IEEE
Date: 09-2018
Publisher: Elsevier BV
Date: 08-2015
Publisher: MDPI AG
Date: 19-02-2014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2014
Publisher: Mary Ann Liebert Inc
Date: 05-2019
Publisher: Springer Science and Business Media LLC
Date: 24-04-2021
DOI: 10.1186/S12905-021-01325-1
Abstract: Women undergoing infertility treatment have poor quality of life. This may cause them to withdraw from or refuse treatment. Women undergoing frozen embryo transfer have a treatment interval. The aim of this study was to investigate the status quo of the fertility quality of life in women undergoing frozen embryo transfer and analyse its predictors. A cross-sectional survey was conducted from August 2019 to August 2020 among women undergoing frozen embryo transfer in a tertiary hospital reproductive centre in Beijing, China. The survey collected demographic characteristics and treatment data and included the fertility problem inventory, the fertility quality of life scale (FertiQoL) and the state-trait anxiety scale. Multiple linear stepwise regression was used to explore the predictors of fertility quality of life. In total, 1062 women completed the survey. Participants reported that they had high levels of fertility-related stress and anxiety during treatment. They also had lower fertility-related quality of life, and the Treatment FertiQoL scored the lowest. The regression results showed that social concern, trait anxiety, duration of treatment and age were risk factors for diminished fertility quality of life. Chinese women undergoing frozen embryo transfer have relatively poor quality of life. The potential predictors of fertility quality of life include social concern, trait anxiety, duration of treatment and age.
Publisher: Springer Science and Business Media LLC
Date: 07-11-2018
Publisher: Oxford University Press (OUP)
Date: 30-07-2020
Publisher: Oxford University Press (OUP)
Date: 30-07-2020
Publisher: MDPI AG
Date: 29-11-2019
DOI: 10.3390/IJMS20236035
Abstract: Syntenin-1 is an essential multi-functional adaptor protein, which has multiple roles in membrane trafficking and exosome biogenesis, as well as scaffolding interactions with either the actin cytoskeleton or focal adhesions. However, how this functional multiplicity relates to syntenin-1 distribution in different endosome compartments or other intracellular locations and its underlying involvement in cancer pathogenesis have yet to be fully defined. To help facilitate the investigation of syntenin-1 biology, we developed two specific monoclonal antibodies (Synt-2C6 and Synt-3A11) to spatially distinct linear sequence epitopes on syntenin-1, which were each designed to be unique at the six-amino acid level. These antibodies produced very different intracellular staining patterns, with Synt-2C6 detecting endosomes and Synt-3A11 producing a fibrillar staining pattern suggesting a cytoskeletal localisation. Treatment of cells with Nocodazole altered the intracellular localisation of Synt-3A11, which was consistent with the syntenin-1 protein interacting with microtubules. In prostate tissue biopsies, Synt-3A11 defined atrophy and early-stage prostate cancer, whereas Synt-2C6 only showed minimal interaction with atrophic tissue. This highlights a critical need for site-specific antibodies and a knowledge of their reactivity to define differential protein distributions, interactions and functions, which may differ between normal and malignant cells.
Publisher: Elsevier BV
Date: 03-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7BM00187H
Abstract: An overview of polydopamine derived nanostructures PDA NPs, capsules, core-shell nanostructures and PDA coatings as well as their application in various biomedical fields.
Publisher: Informa UK Limited
Date: 21-12-2016
Publisher: Springer Science and Business Media LLC
Date: 18-01-2021
Publisher: National Library of Serbia
Date: 2017
Abstract: The failure of electrical conductor grade (EC) aluminum during wire drawing process was investigated. The fractured aluminum wires were subjected to Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray (EDX) analyses for an initial examination. Thermodynamic analyses of molten aluminum interaction with refractories was also carried out using FactSage at 710?C to predict the stable phases. The SEM/EDX analyses has revealed the inclusions in aluminum matrix. The typical inclusions observed were Al2O3, Al3C4 (Al-Carbide) and oxides of refractories elements (Al, Mg, Si and O) that have particle size ranging up to 5 ?m. The transition metal boride particles were not identified during SEM/EDX analyses these might be too fine to be detected with this microscope. The overall investigation suggested that the possible cause of this failure is second phase particles presence as inclusions in the aluminum matrix, and this was associated with the poor quality of melt. During wire drawing process, these inclusions were pulled out of the aluminum matrix by the wiredrawing forces to produce micro-voids which led to ductile tearing and final fracture of wires. It was recommended to use ceramic foam filters to segregate inclusions from molten aluminum.
Publisher: IEEE
Date: 06-2018
Publisher: Springer Science and Business Media LLC
Date: 27-10-2021
Publisher: MDPI AG
Date: 31-05-2022
DOI: 10.3390/MA15113906
Abstract: Enhanced non-linearity and asymmetric behavior of the Cr/metal oxide diode is reported, with the addition of two insulator layers of SnO2 and NiO to form the metal-insulator-insulator-metal (MIIM) configuration. Such an MIIM diode shows potential for various applications (rectifiers and electronic equipment) which enable the femtosecond fast intoxication in MIIM diodes. In this work, nanostructured multi-layer Cr/SnO2/NiO/Cr coatings were fabricated via e-beam evaporation with the following thicknesses: 150 nm/20 nm/10 nm/150 nm. Coatings were characterized via Rutherford backscattering (RBS), scanning electron microscopy (SEM), and two-probe conductivity testing. RBS confirmed the layered structure and optimal stoichiometry of the coatings. A non-linear and asymmetric behavior at .5 V applied bias with the non-linearity maximum of 2.6 V−1 and the maximum sensitivity of 9.0 V−1 at the DC bias point was observed. The promising performance of the coating is due to two insulating layers which enables resonant tunneling and/or step-tunneling. Based on the properties, the present multi-layer coatings can be employed for MIIM application.
Publisher: Springer Science and Business Media LLC
Date: 25-10-2013
Publisher: Elsevier BV
Date: 2021
Publisher: IEEE
Date: 12-2017
Publisher: Oxford University Press (OUP)
Date: 08-2018
Publisher: Wiley
Date: 22-02-2013
Publisher: Informa UK Limited
Date: 02-04-2016
Publisher: MDPI AG
Date: 26-02-2022
Abstract: For specialized applications, it is incumbent to develop new materials that enable manufacturers to develop new processes and designs. For better fuel economy, structural integrity, and lightweight applications, the development of bimetallic steel/aluminum (Al) alloys having a strong interfacial bond is required. Therefore, a mild steel/Al-bearing alloy bimetallic composite was investigated in this study. Firstly, a tin (Sn) interlayer was developed between the steel substrate and the Al-bearing alloy by the tinning process. For further improvement in the interfacial integrity, alumina (Al2O3) nanoparticles were added to the Sn powder during the tinning process. Four different wt.% of Al2O3 nanoparticles of 0.25, 0.5, 1, and 1.5 were added and mixed thoroughly with Sn powder before mixing them with flux prior to the tinning process. Finally, molten Al-bearing alloy (Al–Sn-Si–Cu) was poured over the Al2O3 nanoparticles reinforced tinned steel substrate. A cross-section of the steel/Al-bearing alloy bimetallic composite was prepared for optical microscopy (OM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and shear testing. The cross-section microstructure of the steel/Al-bearing alloy bimetallic composite revealed irregular and discontinuous interfacial layers in the case of the low-temperature (170 °C) tinning process. However, a uniform, continuous interfacial layer was fabricated during the tinning process when additional preheat to the steel substrate and tinning process was adopted. It can be reported that low Al2O3 nanoparticles loading (0.25%) and steel substrate preheating were recommended for the better interfacial layer in the steel/Al-bearing alloy bimetallic composite.
Publisher: Informa UK Limited
Date: 24-02-2021
Publisher: IEEE
Date: 04-2018
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Abdul Khaliq.