Boon Teo

Photothermally responsive Pickering emulsions stabilised by polydopamine nanobowls.

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1TB01796A

Abstract: Pickering emulsions with stimuli responsive properties have attracted mounting research attention owing to their potential for on-demand destabilisation of emulsions. However, a combination of biocompatibility and long-term stability are essential to efficiently apply such systems in biomedical applications, and this remains a significant challenge. To address current limitations, here we report the formation of photothermally responsive oil-in-water (o/w) Pickering emulsions fabricated using biocompatible stabilisers and showing prolonged stability. For the first time, we explore polydopamine (PDA) bowl-shaped mesoporous nanoparticles (PDA nanobowls) as a Pickering stabiliser without any surface modification or other stabiliser present. As-prepared PDA nanobowl-stabilised Pickering emulsions are shown to be pH responsive, and more significantly show high photothermal efficiency under near-infrared illumination due the incorporation of PDA into the system, which has remarkable photothermal response. These biocompatible, photothermally responsive o/w Pickering emulsion systems show potential in controlled drug release applications stimulated by NIR illumination.

Bowl-Shaped Mesoporous Polydopamine Nanoparticles for Size-Dependent Endocytosis into HeLa Cells

Publisher: American Chemical Society (ACS)

Date: 26-08-2021

DOI: 10.1021/ACSANM.1C01897

Exploring the transition of polydopamine-shelled perfluorohexane emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1CP01146D

Abstract: Perfluorocarbon emulsion droplets are interesting colloidal systems with applications in biomedicine. This work describes the use of small- and ultra-small-angle neutron scattering in studying their heat-induced phase transition into microbubbles.

Structural elucidation of polydopamine facilitated by ionic liquid solvation

Publisher: Royal Society of Chemistry (RSC)

Date: 2023

DOI: 10.1039/D2CP05439F

Abstract: The structure of polydopamine has been elucidated for the first time using liquid phase NMR spectroscopy due to its solubility in specific ionic liquids. The solubility was found to be facilitated by the dual electrostatic and dispersion nature of ionic liquid ions.

Synthesis and characterisation of polynorepinephrine-shelled microcapsules via an oil-in-water emulsion templating route

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1TB01786A

Abstract: A facile, emulsion-templated method to produce oil-core capsules with polynorepinephrine shells is presented, for pH-controlled release of actives.

Recent developments in biomolecule-based nanoencapsulation systems for antimicrobial delivery and biofilm disruption

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/D0CC05880G

Abstract: Biomolecules are very attractive nanomaterial components, generally, due to their biocompatibility, biodegradability, abundance, renewability, and sustainability, as compared to other resources for nanoparticle-based delivery systems.

Mesoporous, anisotropic nanostructures from bioinspired polymeric catecholamine neurotransmitters and their potential application as photoacoustic imaging agents.

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2TB01756C

Abstract: Mesoporous polydopamine (PDA) nanobowls, which can be prepared using Pluronic® F-127, ammonia, and 1,3,5-trimethylbenzene (TMB), are one of the most studied anisotropic nanoparticle systems. However, only limited reports on polymerised analogues polynorepinephrine (PNE) and polyepinephrine (PEP) exist. Herein, we present modifications to a one-pot, soft template method, originally applied to make PDA nanobowls, to fabricate new shape-anisotropic nanoparticles (mesoporous nanospheres or "nano-golf balls" and nanobowls) using PNE and PEP for the first time. These modifications include the use of different oil phases (TMB, toluene and

Norepinephrine derived carbon dots for live-cell imaging and effective hemoglobin determination

Publisher: Royal Society of Chemistry (RSC)

Date: 2021

DOI: 10.1039/D1SM00791B

Abstract: Schematic of hydrothermal synthesis of CDs resulting in green fluorescence. Applications of synthesized CDs including cell imaging and hemoglobin detection were then studied.

Recent developments in polynorepinephrine: an innovative material for bioinspired coatings and colloids

Publisher: Royal Society of Chemistry (RSC)

Date: 2022

DOI: 10.1039/D2TB01335E

Abstract: The valuable properties of polynorepinephrine have been discovered in recent decades, enabling development of new functional materials including drug delivery vehicles, antifouling coatings, photothermal agents, sensors, angle-dependent colour materials, and more.

Room temperature synthesis of block copolymer nano-objects with different morphologies: via ultrasound initiated RAFT polymerization-induced self-assembly (sono-RAFT-PISA)

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/D0PY00461H

Abstract: The first room temperature synthesis of diblock copolymer nano-objects with different morphologies using ultrasound (990 kHz) initiated reversible addition-fragmentation chain transfer PISA (sono-RAFT-PISA) in aqueous system.

Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging

Publisher: Wiley

Date: 27-01-2020

DOI: 10.1002/PPSC.201900471

Polynorepinephrine as an Efficient Antifouling-Coating Material and Its Application as a Bacterial Killing Photothermal Agent

Publisher: American Chemical Society (ACS)

Date: 11-08-2020

DOI: 10.1021/ACSABM.0C00578

Abstract: Biomedical device-related infection (BDI) is of great concern in modern clinical and medical applications. Various approaches to combat BDI are based on two major principles: the prevention of biofoulants adhering on medical devices and the ability to eradicate biofouling once formed. To minimize the risk of BDI, an antifouling coating with bactericidal ability is highly desirable. In this work, we report on the use of polynorepinephrine (PNE) as a promising strategy to prevent BDI due to its excellent antifouling and photothermal bacterial killing capabilities. PNE coatings show superior protein resistance against a model biofoulant (bovine serum albumin (BSA)) when compared with poly(ethylene glycol) (PEG) and polydopamine (PDA) coatings. The antifouling mechanism between BSA protein molecules and coating films is investigated using atomic force microscopy (AFM). We also demonstrate that PNE-modified surfaces show remarkable bacterial killing ability against both Gram-positive

Controlling the Size and Polymorphism of Calcium Carbonate Hybrid Particles Using Natural Biopolymers

Publisher: American Chemical Society (ACS)

Date: 02-01-2020

DOI: 10.1021/ACS.CGD.9B01057

Bioinspired polynorepinephrine nanoparticles as an efficient vehicle for enhanced drug delivery.

Publisher: Royal Society of Chemistry (RSC)

Date: 2020

DOI: 10.1039/C9TB02375E

Abstract: An innovative drug delivery vehicle based on polynorepinephrine (PNE) with controllable size modification, high delivery efficacy and low cytotoxicity is presented. Highly monodisperse PNE nanoparticles are fabricated by the autoxidation of norepinephrine monomers in an alkaline water/ethanol mixture via stirring at room temperature. We demonstrated the facile optimization of particle size to enhance particle stability and biocompatibility by varying solvent and monomer dosage. To demonstrate the suitability and potential application of PNE particles in cancer therapy, we show that these particles are biocompatible in vitro with HeLa cells and in vivo in zebrafish embryos. After loading the anti-cancer chemotherapy drug doxorubicin (DOX) into the PNE nanoparticles, a consistent and pH responsive drug release profile of DOX was achieved in different environmental conditions. It was found that DOX loaded PNE nanoparticles (PNE/DOX) exhibit much higher pharmaceutical cytotoxicity than free DOX on HeLa cells. Furthermore, the amount of drug released was significantly enhanced in acidic environments that mimic the pH of extracellular tumour microenvironments. Taken together, the PNE nanoparticles represent a new class of melanin particles with promising potential in drug delivery and as a therapeutic platform for cancer treatment.

Efficient Cellular Internalization and Transport of Bowl-Shaped Polydopamine Particles

Publisher: Wiley

Date: 23-08-2020

DOI: 10.1002/PPSC.202000166

Monash University

Location: Australia

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Discovery Projects - Grant ID: DP210102677

Start Date: 06-2021

End Date: 12-2024

Amount: $315,000.00

Funder: Australian Research Council

Linkage Projects - Grant ID: LP210100175

Start Date: 05-2023

End Date: 05-2023

Amount: $617,990.00

Funder: Australian Research Council

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100053

Start Date: 06-2020

End Date: 06-2022

Amount: $482,055.00

Funder: Australian Research Council