ORCID Profile
0000-0002-9117-4713
Current Organisations
University of Miami
,
University of Wollongong
,
University of Jember
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Publisher: SAGE Publications
Date: 2022
DOI: 10.1177/1934578X211068926
Abstract: Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds to combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into the Indonesian medicinal plants Swietenia mahagoni and Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri- O-caffeoylquinic acid (4) to be the most active against Plasmodium falciparum 3D7 and Dd2 strains with IC 50 values of 8.2 and 8.8 µM, respectively. No cytotoxicity was observed against Human Embryonic Kidney cells at a concentration of 40 µM.
Publisher: Enviro Research Publishers
Date: 16-08-2019
Abstract: roteins hydrolyzed from melinjo seeds (Gnetum gnemon) at green (GM), yellow (YM) and red (RM) stages of maturity were studied for their effectiveness in antioxidant and antidiabetic activities. The seed protein extract was hydrolyzed using alcalase 2.4L, and the resulting hydrolysates with the highest degree of hydrolysis, protein profile, and the most potent contributors to antioxidant and invitro antidiabetic activities were identified. The degree of hydrolysis value of hydrolysates ranged from 52-84%, and the SDS-PAGE protein profile showed two distinct bands in which the band with molecular weight of 30 kDa degraded more intensively. Antioxidant capacity was measured using different standard methods, including radical cation 2,2-azinobis-(3-ethylbenzothizoline-6-sulphonate) (ABTS•+) assay, hydroxyl radical (OH•), and superoxide anion (O2•-) scavenging. The green hydrolysate (GMH) had significantly higher (p .05) free radical scavenging (ABTS•+, OH•, and O2•-) activities than that of the yellow hydrolysate (YMH) and red hydrolysate (RMH). However, invitro antidiabetic testing was performed based on the inhibitory activity of α-amylase and α-glucosidase. GMH was found to be more effective than YMH and RMH. These results showed that the antioxidant and antidiabetic activity in hydrolyzed GM protein has high potential to be utilized as natural nutraceuticals.
Publisher: The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
Date: 2022
Publisher: Innovare Academic Sciences Pvt Ltd
Date: 21-09-2019
DOI: 10.22159/AJPCR.2019.V12I11.34967
Abstract: Objective: The tobacco leaves are a rich source of many biologically active substances. Flavonoids are one of the bioactive substances contained in tobacco leaves with a wide range of pharmacological properties. This study has been aimed to formulate the antibacterial periodontal gel containing the flavonoids fraction of Kasturi tobacco (Nicotiana tabacum) leaves. Methods: Fraction flavonoids obtained from methanolic extracts of tobacco leaves, which have been purified from nicotine. Different concentrations of flavonoids fraction (0, 25, 0,5, 1, 2, and 4 mg/ml) were prepared with Carbopol-974P. The strength of flavonoid gel adhesion in ex vivo mucosa was tested by the falling liquid film method. Evaluation of in vitro antibacterial agent was followed by the disk diffusion method. Results: The flavonoid gels have better adhesion parameters (time, strength, and distance) than gel bases. The antimicrobial by the zone of inhibition studies proved that flavonoids periodontal gels with concentrations of 4 mg/ml are highly active against Porphyromonas gingivalis with the zone of inhibition mm which was higher than quercetin gel formulations (control groups). Conclusion: Gel formulation containing the flavonoids fraction of Kasturi tobacco (N. tabacum) leaves could be a good candidate for periodontal gel with good mucoadhesive gel and antibacterial agent.
Publisher: Informa UK Limited
Date: 02-01-2022
Publisher: Informa UK Limited
Date: 24-02-2020
Publisher: Office of Academic Resources, Chulalongkorn University - DIGITAL COMMONS JOURNALS
Date: 23-09-2020
Abstract: This study aims to describe the treatment preference, especially in relation to traditional medicine, modern health care and a combination of both, in diarrheal cases among the Tengger ethnic minority group. A cross-sectional survey was conducted in all eight villages of Tosari District, Pasuruan Regency, East Java Province. Tengger people were major resident in the area for generations. Convenience s ling and a face-validated structured questionnaire were used to recruit and face-to-face interview 377 Tengger people. The study found that modern health care was the dominant preference (52%, n = 196) selected by Tengger people when they have an episode of diarrhea, compared to traditional medicines and mixed approach. Most respondents opted to visit one facility or to stay at home (64.3%, n = 242). Statistical significant relationships were found between treatment choice and age ( p 0.001), sex ( p 0.001), religion ( p = 0.011), distance ( p 0.001), educational background ( p 0.001) and job ( p 0.001). A clear pattern between treatment choice and age was revealed with younger groups tended to choose modern health care, while older groups more preferred the traditional approach. This work could provide an insight that when the young Tengger people are having uncomplicated and common health illness, such as diarrhea, they tend to use modern treatment approach. This study fulfilled an identified need to explore the trend of treatment approach across generations in the Tengger society as a model of the minor ethnic group in Indonesia.
Publisher: Elsevier BV
Date: 02-2023
Publisher: Elsevier BV
Date: 2020
Publisher: Maad Rayan Publishing Company
Date: 17-07-2020
DOI: 10.34172/BI.2021.41
Abstract: Introduction: In this work, we used a thread-paper microfluidic device (μTPAD) system, where a threaded part for the handling of the whole blood s les and a paper part for the reaction of plasma with immobilized bioreagents integrated into woman pad as a wearable sensing device namely as smart women pad. The μTPAD as a wearable smart woman pad is developed for the detection of pH and urea in mensuration blood as real s les. Methods: This combined device was constructed to cover the elements required, that is, separation of red blood cell, conditioning, analyte reaction, and colorimetric detection. The color change in sensing areas was measured in the RGB values via a smartphone using the Color Grab after a smart woman pad was used. The thread allowed red blood cell s ling and separation, while the paper microfluidic device was used for conditioning, biorecognition, and colorimetric transduction of pH and urea as analytes. Results: The time needed for analysis was measured as 110 s using the equilibrium method for both analytes, with a limit of detection (LOD) of 72.55 μg/mL for urea, with precision around 1.68%, while for pH around 0.80%. The smart woman pad allowed rapid detection of pH and urea in menstruation blood as real s les for monitoring of the kidney functions, and the results showed an agreement with the conventional methods that have been generally used in the clinical laboratory. Conclusion: The smart woman pad has the potential to be used as a wearable device to monitor the health status of the user via its blood mensuration analysis.
Publisher: UPT Penerbitan Universitas Jember
Date: 16-07-2019
Abstract: Karangpring is one tourist destination villages in Jember district which is popular with beautiful large rose field areas. Therefore, this area grows to be a leading producer of rose flowers in Jember district. However, the bulky presence of these flowers made its price becomes lower in regular days. Local community only uses and sells these fresh flowers as the flower for funeral. The rose flower has a great potency to be explored as a source of rose essential oil production. To date, there is no previous research on studying rose flowers from Karangpring village for its potency on the essential oil production. In this research, rose flowers were subjected to be extracted of its essential oil using two extraction methods, distillation, and enfleurage. Hydrodistillation resulted two phases of distillates, above part formed a cloudy white phase as a normal essential oil extracted from plants, and the lower phase was an aqueous phase containing rose hydrosols. Both phases of these condensates were analyzed using GCMS. Data explained that above phase, with a yield oil of 0.07%, only contains long-chain hydrocarbons such as n-nonadecane, n-heptadecane, 9-nonadecene, and eicosane, while the lower phase only contains 2-phenylethyl alcohol. On the other hand, enfleurage of fresh rose flowers resulted in 0.06% oil yield. GCMS analysis of this oil shows that 2-phenylethyl alcohol, eugenol, and phenylacetic acid are three major compounds which take more than 85% of total rose absolute. The results show that enfleurage is a better method for extracting rose oil in better quality than using the distillation method, in term of the variety of volatile components. Meanwhile, hydrodistillation is still benefiting from producing rose water that is qualified as an industrial additive agent for food and cosmetic productions or even a new potent of agromedicine products. Keywords: rose, rose oil, rose water, rose absolute, distillation, enfleurage.
Publisher: EManuscript Technologies
Date: 06-03-2023
Publisher: Royal Society of Chemistry
Date: 30-08-2023
DOI: 10.1039/BK9781837672097-00165
Abstract: Flammulina velutipes is one of the most important commercialized mushrooms across the globe, with an annual market share of billions of dollars. The mushroom is consumed not only due to its nutritional value but also its medicinal properties 76 secondary metabolites have been isolated, characterised, and reported to show a range of health benefits, from antihypertensive to anticancer properties. Nevertheless, Hazard Analysis and Critical Control Points (HACCP) system practice is necessary to warrant the value as well as safety of cultivated mushroom products as the global market for mushroom is increasing every year.
Publisher: SAGE Publications
Date: 06-2019
Publisher: American Geophysical Union (AGU)
Date: 2023
DOI: 10.1029/2022JC019168
Abstract: The Deep Western Boundary Current (DWBC) is the main component of the deep limb of the Atlantic Meridional Overturning Circulation (AMOC). Off northeast Brazil, the DWBC breaks up into southwestward‐propagating anticyclones. In this study, we investigate the breakup mechanism with hydrographic observations, eddy‐resolving numerical model outputs, and theory. Here, we present a quasi‐synoptic map of geostrophic velocities and stream function at the DWBC core level between 2.5°S and 11°S. We observe, in horizontal distributions of velocities, that the DWBC breakup site is linked to a topographic feature of the Brazilian continental margin centered at 8°S: the Pernambuco Plateau (PP). Moreover, both observations and model outputs hint at a possible DWBC separation near the PP preceding anticyclone genesis. We test, with three different theories from the literature, whether or not the DWBC separates at 8°S. The results of the tests converge to indicate that the DWBC undergoes a local and intermittent inertial separation while contouring the PP. Downstream of its separation at the plateau, the DWBC sheds eddies similarly to previously reported laboratory experiments. In addition, a regional analysis of energy transfer shows that barotropic instability significantly contributes to the anticyclones growth between 8°S and 13°S. Analysis of the energy budget and separation of waters related to the AMOC pathways into the basin interior provide a better understanding for later studies about heat fluxes and ventilation in the deep tropical South Atlantic.
Publisher: MDPI AG
Date: 03-11-2022
DOI: 10.3390/MOLECULES27217532
Abstract: The archipelagic country of Indonesia is inhabited by 300 ethnic groups, including the indigenous people of Tengger. Based on the reported list of medicinal plants used by the Tengger community, we have reviewed each of them for their phytochemical constituents and pharmacological activities. Out of a total of 41 medicinal plants used by the Tengerrese people, 33 species were studied for their phytochemical and pharmacological properties. More than 554 phytochemicals with erse molecular structures belonging to different chemical classes including flavonoids, terpenoids, saponins and volatiles were identified from these studied 34 medicinal plants. Many of these medicinal plants and their compounds have been tested for various pharmacological activities including anti-inflammatory, antimicrobial, wound healing, headache, antimalarial and hypertension. Five popularly used medicinal plants by the healers were Garcinia mangostana, Apium graveolens, Cayratia clematidea, Drymocallis arguta and Elaeocarpus longifolius. Only A. graviolens were previously studied, with the outcomes supporting the pharmacological claims to treat hypertension. Few unexplored medicinal plants are Physalis lagascae, Piper lum, Rosa tomentosa and Tagetes tenuifolia, and they present great potential for biodiscovery and drug lead identification.
Publisher: MDPI AG
Date: 03-12-2019
DOI: 10.3390/MOLECULES24234419
Abstract: Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for their anti-infective and anti-cancer activities. An isoquinoline backbone is a major structural alkaloid moiety of the Annona genus, and more than 83 alkaloids have been isolated from this genus alone. Crude extracts of Annona genus are reported with moderate activities against Plasmodium falciparum showing larvicidal activities. However, no pure compounds from the Annona genus were tested against the parasite. The methanol extract of Annona muricata showed apparent antimicrobial activities. The isolated alkaloids from this genus including liriodenine, anonaine, asimilobine showed sensitivity against Staphylococcus epidermidis. Other alkaloids such as (+)-Xylopine and isocoreximine indicated significant anti-cancer activity against A549 and K-562 cell lines, respectively. This review revealed that the alkaloids from Annona genus are rich in structural ersity and pharmacological activities. Further exploration of this genus and their alkaloids has potential for developing novel anti-infective and anticancer drugs.
Publisher: Elsevier BV
Date: 10-2020
Publisher: A and V Publications
Date: 2020
Publisher: American Chemical Society (ACS)
Date: 07-08-2017
DOI: 10.1021/ACS.JNATPROD.7B00085
Abstract: Ceratodon purpureus is a cosmopolitan moss that survives some of the harshest places on Earth: from frozen Antarctica to hot South Australian deserts. In a study on the survival mechanisms of the species, nine compounds were isolated from Australian and Antarctic C. purpureus. This included five biflavonoids, with complete structural elucidation of 1 and 2 reported here for the first time, as well as an additional four known phenolic compounds. Dispersion-corrected DFT calculations suggested a rotational barrier, leading to atropisomerism, resulting in the presence of diastereomers for compound 2. All isolates absorbed strongly in the ultraviolet (UV) spectrum, e.g., biflavone 1 (UV-A, 315-400 nm), which displayed the strongest radical-scavenging activity, 13% more efficient than the standard rutin p-coumaric acid and trans-ferulic acid showed the highest UV-B (280-315 nm) absorption. The more complex and abundant 1 and 2 presumably have dual roles as both UV-screening and antioxidant compounds. They are strongly bound to Antarctic moss cell walls as well as located inside the cells of moss from both locations. The combined high stability and photoprotective abilities of these isolates may account for the known resilience of this species to UV-B radiation and its survival in some of the toughest locations in the world.
Publisher: The Electrochemical Society
Date: 07-2021
Abstract: The use of a disposable pipette tip was studied to create a lab-on-a-tip approach. The configuration of a pipette tip, fiber optics, and paper-based biosensor show the compatibility of creating a novel one-shot optical biosensor for carbosulfan as carbamate pesticide. Under optimal experimental parameters, the lab-on-a-tip could detect carbosulfan in the linear range value of 10–22000 μ g l −1 with a detection limit value of 10 μ g l −1 . The results show good agreement with the HPLC method.
Publisher: Maulana Malik Ibrahim State Islamic University
Date: 31-03-2023
Abstract: Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil s les were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done.
Publisher: MDPI AG
Date: 24-01-2020
DOI: 10.3390/BIOM10020181
Abstract: This is an extensive review on epiphytic plants that have been used traditionally as medicines. It provides information on 185 epiphytes and their traditional medicinal uses, regions where Indigenous people use the plants, parts of the plants used as medicines and their preparation, and their reported phytochemical properties and pharmacological properties aligned with their traditional uses. These epiphytic medicinal plants are able to produce a range of secondary metabolites, including alkaloids, and a total of 842 phytochemicals have been identified to date. As many as 71 epiphytic medicinal plants were studied for their biological activities, showing promising pharmacological activities, including as anti-inflammatory, antimicrobial, and anticancer agents. There are several species that were not investigated for their activities and are worthy of exploration. These epipythes have the potential to furnish drug lead compounds, especially for treating cancers, and thus warrant indepth investigations.
Publisher: Secretariat of The Indonesian Biomedical Journal
Date: 12-2022
DOI: 10.18585/INABJ.V14I4.2027
Abstract: BACKGROUND: Cervical cancer has a high rate of morbidity and mortality in women with cancer. Recent studies have found that tobacco (Nicotiana tabacum L.) is a potential source of anti-cancer agents. Hence, this study was conducted to determine the potential of Kasturi tobacco leaf resinoids as apoptotic agents against cervical cell malignancies, since it has not been fully elucidated before.METHODS: The phytochemical ersity of Kasturi tobacco resinoids was generated by gas chromatography-mass spectrometry (GC-MS) analysis followed by spectral similarity to National Institute of Standards and Technology (NIST) database. Cytotoxicity and proliferative activity of HeLa cells treated with Kasturi tobacco resinoids at various concentrations were evaluated by MTT assay. The expression of Caspase-3, cyclooxygenase-2 (COX-2) and heat shock protein 90 (HSP-90) in HeLa cells was analyzed by immunocytochemistry. Next, the migration ability of HeLa cells was observed by the scratch method.RESULTS: Kasturi tobacco resin contains 4,8,13-cyclotetradecatriene-1,3-diol, 1,5,9-trim with α-2,7,11-cembratriene-4,6-diol (α-CBD) structure in the form of a diterpenoid compound with the chemical formula C20H34O2 and a molecular weight of 306 Da. Kasturi tobacco resinoid with IC50 value of 2500 μg/mL inhibited proliferative activity during 72 hours. At a concentration of 1¼ IC50 and incubation for 48 hours, Caspase-3 expression increased by 74.1%, while COX-2 and HSP-90 expression decreased by 28.3% and 26.1%, respectively. HeLa cell migration was inhibited by Kasturi tobacco resinoid at 24 hours incubation.CONCLUSION: Kasturi tobacco resinoids with a concentration of 1¼ IC50 have potential as cervical anti-cancer agents by increasing Caspase-3 expression and decreasing COX-2 and HSP-90 expression within 48 hours.KEYWORDS: Kasturi tobacco resinoids, cervical cancer, anti-cancer agent, proliferative activity
Publisher: American Roentgen Ray Society
Date: 07-2018
DOI: 10.2214/AJR.17.19179
Publisher: International Journal of Technology
Date: 09-05-2023
Publisher: Informa UK Limited
Date: 02-01-2019
Publisher: UNS Solo
Date: 10-03-2020
Abstract: Abstract. Lovabyta NS, Jayus J, Nugraha AS. 2020. Bioconversion of isoflavones glycoside to aglycone during edamame (Glycine max) soygurt production using Streptococcus thermophillus FNCC40, Lactobacillus delbrueckii FNCC41, and L. plantarum FNCC26. Bio ersitas 21: 1358-1364. Due to its strong radical-scavenging and antioxidative activity, isoflavones in soybeans have received great attention for the development of functional foods. This study focused on bioconversion of isoflavones glycoside into its aglycone form of edamame green soymilk fermented with three lactic acid bacteria (LAB), i.e., S. thermophilus FNCC40, L. bulgaricus FNCC41, and L. plantarum FNCC26 to produce soygurt. Green soymilk was fermented with 6% (v/v) of LABs as a starter culture for 24 hours at 37ºC. Its antioxidative activity were measured using DPPH free radical scavenging activity method. Daidzein and genistein released during fermentation were fractionated using HPLC and detected further by LCMS to confirm the presence of these two substances. The results showed that the population density of starter culture in green soymilk reached 109 CFU/mL, and the pH decrease from 6.8 to 3.5. All LABs cultures used in the fermentation process were able to produce free aglycone, releasing more daidzein and genistein. Increasing daidzein and genistein content in soygurt results in increasing antioxidative activity. The highest antioxidative activity (IC50 = 41.01 mg/mL) was found in the soygurt fermented with S. thermophilus FNCC40. This finding indicates that S. thermophilus FNCC40, L. bulgaricus FNCC41, and L. plantarum FNCC26 are potential as an effective starter culture to produce a soygurt with good antioxidant activity.
Publisher: Elsevier BV
Date: 2020
Publisher: Informa UK Limited
Date: 06-05-2021
DOI: 10.1080/14786419.2020.1761361
Abstract: An extensive phytochemical study of a foliose lichen from Indonesia,
Publisher: Elsevier BV
Date: 08-2014
DOI: 10.1016/J.FORSCIINT.2014.05.003
Abstract: The larvae of necrophagous fly species are used as forensic tools for the determination of the minimum postmortem interval (PMI). However, any ingested drugs in corpses may affect larval development, thus leading to incorrect estimates of the period of infestation. This study investigated the effects of meth hetamine and its metabolite, p-hydroxymeth hetamine, on the forensically important Australian blowfly Calliphora stygia. It was found that the presence of the drugs significantly accelerated larval growth and increased the size of all life stages. Furthermore, drug-exposed s les remained as pupae for up to 78 h longer than controls. These findings suggest that estimates of the minimum PMI of meth hetamine-dosed corpses could be incorrect if the altered growth of C. stygia is not considered. Different temperatures, drug concentrations and substrate types are also likely to affect the development of this blowfly. Pending further research, the application of C. stygia to the entomological analysis of meth hetamine-related fatalities should be appropriately qualified.
Publisher: Universitas Gadjah Mada
Date: 26-03-2019
Publisher: FapUNIFESP (SciELO)
Date: 2022
DOI: 10.1590/FST.66520
Publisher: Springer Science and Business Media LLC
Date: 16-10-2023
Publisher: UNS Solo
Date: 29-04-2021
Abstract: Abstract. Jayus J, Akroman R, Nurhayati, Nugraha AS, Piluharto B, Seviour RJ. 2021. Structural elucidation of the exopolysaccharide produced by Curvularia lunata isolate RJ01. Bio ersitas 22: 2699-2705. An exopolysaccharide (EPS) was recovered from culture filtrates of the fungus Curvularia lunata isolate RJ01 prepared in Jember, Indonesia. Based on a prominent peak at 883 cm-1, FTIR analysis suggested it is a ?-D-glucan, a proposal confirmed by subsequent nuclear magnetic resonance (NMR) analysis which showed anomeric protons omit the signal at d4.37 and 4.8 ppm, and sugar proton signal in the region of 2.5 to 4.2 ppm. High-performance liquid chromatography (HPLC) analysis of the acid hydrolysates of this glucan revealed the presence of glucose (64%) and a mixture of galactose and mannose (36%). Digestion with (1-- )-?- and (1-- )-?-glucanase from Acremonium sp. IMI 383068 gave consistent linear products of (1-- )-?-glycosidic linkages, since the glucan was digested by (1-- )-?-glucanase only. The rheological behavior of aqueous EPS solution suggests it behaves as a pseudoplastic non-Newtonian fluid and thus has the potential for use as a thickening agent in foods. This study is the first report on the structural elucidation of EPS from C. lunata.
Publisher: Informa UK Limited
Date: 20-02-2015
DOI: 10.1080/14786419.2015.1013470
Abstract: Phytochemical studies of the previously unexplored stem of Boerhavia erecta from Burkina Faso, resulted in the isolation of an unreported glycoside 4, 2,3-dihydroxypropylbenzoate-3-O-β-[4″-methoxy] glucuronide as well as seven known glycosides (1-3, 5-8). The major isolate 5 and 8 indicated a significant inhibition against HIV integrase (IC50 10 and 22 μg/mL, respectively). The extracts and isolates were also tested for anti-malarial activity, but insignificant activity was observed.
Publisher: MDPI AG
Date: 08-10-2020
DOI: 10.3390/BIOM10101420
Abstract: Cancer is a serious health burden on global societies. The discovery and development of new anti-cancer therapies remains a challenging objective. Although it has been shown that lichen secondary metabolites may be potent sources for new anti-cancer agents, the Indonesian- grown folious lichens, Physcia millegrana, Parmelia dilatata and Parmeila aurulenta, have not yet been explored. In this study exhaustive preparative high-performance liquid chromatography was employed to isolate the lichen constituents with spectroscopic and spectrometric protocols identifying nine depsides 9–17, including the new methyl 4-formyl-2,3-dihydroxy-6-methylbenzoate 13. The cytotoxicity of the depsides towards cancer cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated lowest toxicity of the depsides towards human A549 lung cancer cells. Importantly, the di-depsides (11, 12 and 17) showed greatest toxicity, indicating that these structures are biologically more active than the mono-depsides against the HepG2 liver cancer, A549 lung cancer and HL-60 leukemia cell lines.
Publisher: Hindawi Limited
Date: 11-2022
DOI: 10.1155/2022/5729217
Abstract: Stenochlaena palustris (Burm.f.) Bedd. (Blechnaceae) or Kelakai is a traditional medicinal plant found in the Indonesian islands of Borneo and Sumatra. It has been used to treat wound healing, infection, and diabetes. This study looked into the free radical scavenging activity, antiplasmodial activity, toxicity, and antibacterial activity against pathogenic bacteria. The species’ aerial part was extracted with methanol, followed by a liquid-liquid extraction against (n-hexane, dichloromethane, and ethyl acetate). The extracts’ free radical scavenging activities were determined using DPPH and NO radicals. The antiplasmodial and toxicity assays were conducted using two Plasmodium falciparum strains (3D7 and W2) and the brine shrimp lethality test. In addition, antibacterial activity was determined using the well diffusion method. The results revealed that ethyl acetate depicted potential activities toward the assay. The ethyl acetate showed potential free radical scavenging activities with an IC50 value of 51.63 ± 0.46 μg/mL (DPPH) and 60.03 ± 0.65 μg/mL (NO). The antiplasmodial activities showed that the ethyl acetate had potential activities among the extracts with an IC50 value of 11.06 ± 0.45 μg/mL. However, all the extracts demonstrated nontoxic toward Artemia salina with LC50 1000 μg/mL. Furthermore, the ethyl acetate demonstrated intermediate susceptibility against B. cereus ATCC 10876, V. parahaemolyticus ATCC 17802, L. monocytogenes ATCC 7644, and S. Typhimurium ATCC 14028 at a concentration of 500 μg/disc. According to these findings, the ethyl acetate extract of S. palustris (Burm.f.) Bedd is a promising source of natural antioxidants and antiplasmodial agents.
Publisher: Center for Journal Management and Publication, Lambung Mangkurat University
Date: 15-02-2023
Publisher: SPIE
Date: 06-07-2018
DOI: 10.1117/12.2316498
Publisher: International Pharmaceutical Federation (FIP)
Date: 10-10-2023
Publisher: Rasayan Journal of Chemistry
Date: 2022
DOI: 10.31788/RJC.2022.1548027
Abstract: Lichen has been investigated for discovering new antibacterial agents. Although Indonesia is considered one of the mega erse countries and a home to a erse array of lichen species, research on lichens for medicinal properties remains scarce. In this study, an intensive semi-preparative High-Performance Liquid Chromatography successfully isolated a major compound from Phyloporon aciculare, with its molecular structure proposed as methyl 2,4- dihydroxy-3,6-dimethylbenzoate by Nuclear Magnetic Resonance spectral and was confirmed by Mass Spectrometry data analysis. The crude extract of the lichen possessed a selective antibacterial activity in which significantly inhibited Kocuria rhizophila by 96.9% at a 100 µg/mL concentration. In addition, previous reports on methyl 2,4-dihydroxy3,6-dimethylbenzoate from other species indicated the compound to have antibacterial, anti-inflammatory, and anticancer activities.
Publisher: MDPI AG
Date: 23-12-2020
DOI: 10.3390/W13010009
Abstract: Medical water therapy (also called medical hydrology) is practiced worldwide both for relaxation and treatment of diseases. While this practice is still thriving in Bhutan, there is a lack of proper documentation and critical study. Therefore, the current study reports on the water therapies practiced in Bhutan and their health benefits. We used four-stage process: (1) a review of literature on balneotherapy (both traditional textbooks and scientific papers) (2) listing and surveying the hot springs, mineral, and holy spring waters (3) reviewing the health records of the patients maintained at the traditional hospitals and interviewing traditional physicians and patients about health benefits and (4) reviewing available literature to identify existing clinical trials data to provide evidence for hydrotherapies. We found three main forms of hydrotherapies are practiced in Bhutan, which comprises herbal bath therapy, balneotherapy, and spiritually empowered waters. The most popular hydrotherapies are herbal bath and hot spring therapies. Herbal bath therapy needs traditional physicians’ prescriptions, while hot springs do not require it. Through field surveys, ten different hot springs (tsha-chu) and 17 medicinal water or mineral springs (sman-chu), and 17 holy spring-waters (sgrub-chu) were identified. In general, medical water therapies are used by the Bhutanese people to treat various ailments, including gastritis, neurological disorders, arthritis, dermatological diseases, and rheumatological and musculoskeletal disorders. Even though a lack of scientific evidence makes it difficult to draw concrete conclusions on their traditionally claimed efficacy and safety, there are clinical evidences documented from other countries.
Publisher: Informa UK Limited
Date: 02-01-2023
Publisher: Penerbit Universiti Kebangsaan Malaysia (UKM Press)
Date: 30-11-2020
Publisher: MDPI AG
Date: 20-01-2023
DOI: 10.3390/DDC2010002
Abstract: Diabetes mellitus prevalence in Indonesia reached 19.5 million cases, which has affected the productive age population. The indigenous people of Indonesia are blessed with the second largest bio ersity in the world, including vegetables, which are also prepared as medicaments. Vegetables are well-known as natural antioxidants which evolved in metabolic disease prevention, including diabetes mellitus. One of the Government of Indonesia’s strategic plans in health is to develop new antidiabetic from nature. In this study, nineteen vegetable species were collected and evaluated for their antioxidant activity followed by computational-based bioprospecting. The study indicated Ipomoea aquatica, Paederia foetida, Plumbago zeylanica, Nauclea pallida, Sauropus androgynus, Wrightia pubescens, and Psophocarpus tetragonolobus to contain high antioxidant components. Computational experiments on chemical constituents previously reported from the same species showed potent compounds with high affinity against α-glucosidase (3a4a). 7-O-β-D-glucopyranosyl-dihydroquercetin-3-O-α-D-glucopyranoside 1, stigmasterol 7, and chitanone 12 are the most potent compounds from Ipomoea aquatica, Paederia foetida, and Plumbago zeylanica, respectively, which are superior to a standard drug, acarbose. The four vegetable species are feasible for conventional drug sources or developed as botanical dosage according to the Indonesian government’s strategic plan. Further studies are necessary to ensure adequate preclinical and clinical data to meet the requirement of safe and potent medicine. Nevertheless, Nauclea pallida and Psophocarpus tetragonolobus are valuable species with potent yet understudied antioxidant sources.
Publisher: Rasayan Journal of Chemistry
Date: 2021
Publisher: Informa UK Limited
Date: 08-07-2019
Publisher: Galaxy Science
Date: 09-03-2021
Publisher: Elsevier BV
Date: 12-2023
Location: United States of America
Location: United States of America
No related grants have been discovered for Ari Nugraha.