ORCID Profile
0000-0002-3463-0786
Current Organisation
University of Tokyo
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Publisher: American Chemical Society (ACS)
Date: 16-08-2023
Publisher: Wiley
Date: 07-03-2021
Abstract: The presence of microdomes can significantly increase the surface roughness, contact area, and deformability of materials, which have been adopted in many fields including microfluidics, wearable devices, and microanalysis systems. However, the shape of liquid metal (LM) droplet is defined by the density and surface energy, which has very limited room to tune. In this work, a simple, low‐cost method to effectively control the profile of LM using the masked amalgamation is presented. The LM amalgamates the masked copper surface to create the complex microdomes with various aspect ratios, sizes, profiles, and structures. The concave dome replicated from the LM mold has been demonstrated to enhance the microfluidic mixing performance. With a pattern transfer technique, the microconvex domes can be patterned on the surface of stretchable conductive composites to develop a flexible and sensitive pressure sensor. This sensor exhibits a fast response time, a wide working range, and an enhanced sensitivity for detecting small strains. As such, the fabricated microdomes exhibit a great potential to enable the fabrication of high‐performance sensors, microfluidic platforms, and micro total analysis systems.
Publisher: AIP Publishing
Date: 04-2020
DOI: 10.1063/1.5134125
Publisher: MDPI AG
Date: 11-2016
DOI: 10.3390/MI7110195
Publisher: Elsevier BV
Date: 08-2018
Publisher: American Chemical Society (ACS)
Date: 30-10-2023
Publisher: Springer Science and Business Media LLC
Date: 12-12-2018
Publisher: American Chemical Society (ACS)
Date: 29-04-2021
Publisher: MDPI AG
Date: 19-10-2021
DOI: 10.3390/BIOS11100405
Abstract: Microfluidics offer microenvironments for reagent delivery, handling, mixing, reaction, and detection, but often demand the affiliated equipment for liquid control for these functions. As a helpful tool, the capillary pressure control valve (CPCV) has become popular to avoid using affiliated equipment. Liquid can be handled in a controlled manner by using the bubble pressure effects. In this paper, we analyze and categorize the CPCVs via three determining parameters: surface tension, contact angle, and microchannel shape. Finally, a few application scenarios and impacts of CPCV are listed, which includes how CPVC simplify automation of microfluidic networks, work with other driving modes make extensive use of microfluidics by open channel, and s ling and delivery with controlled manners. The authors hope this review will help the development and use of the CPCV in microfluidic fields in both research and industry.
Publisher: MDPI AG
Date: 24-04-2022
DOI: 10.3390/BIOS12050270
Abstract: Surface-enhanced Raman scattering (SERS) detection requires dense hotspots and a uniform distribution of analytes to obtain a stable signal with good repeatability. However, due to the coffee-ring effect on the hydrophilic substrate, and the difficulty of droplet manipulation on the superhydrophobic substrate, few substrates can ensure that the analytes are evenly distributed. In this work, we develop a method that can efficiently enrich plasmonic hotspots for SERS measurement on the superhydrophobic concave dome array (SCDA). The SCDA is formed by spraying hydrophobic silica nanoparticles onto a polydimethylsiloxane (PDMS) slab with a concave dome array that can physically confine the droplets and overcome the coffee-ring effect. During droplet evaporation, the SCDA is driven by a horizontal spinner, and the droplets spin on the SCDA, enabling the plasmonic nanoparticles to become closely packed to form the SERS hotspots. The limit of detection (LOD) of the dynamic-enriched SERS hotspots for crystal violet and methylene blue can reach up to 10−11 M. Moreover, the LOD for melamine in milk can reach 5 × 10−7 M, which is lower than the safety threshold defined by the Food and Drug Administration (FDA). Based on this SERS platform, an effective, low-cost, and simple method for SERS detection in analytical chemistry and food safety is highly expected.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9LC00482C
Abstract: Microalgae cells have been recognized as a promising sustainable resource to meet worldwide growing demands for renewable energy, food, livestock feed, water, cosmetics, pharmaceuticals, and materials. In order to ensure high-efficiency and high-quality production of biomass, biofuel, or bio-based products, purification procedures prior to the storage and cultivation of the microalgae from contaminated bacteria are of great importance. The present work proposed and developed a simple, sheathless, and efficient method to separate microalgae Chlorella from bacteria Bacillus Subtilis in a straight channel using the viscoelasticity of the medium. Microalgae and bacteria migrate to different lateral positions closer to the channel centre and channel walls respectively. Fluorescent microparticles with 1 μm and 5 μm diameters were first used to mimic the behaviours of bacteria and microalgae to optimize the separating conditions. Subsequently, size-based separation in Newtonian fluid and in viscoelastic fluid in straight channels with different aspect ratios was compared and demonstrated. Under the optimal condition, the removal ratio for 1 μm microparticles and separation efficiency for 5 μm particles can reach up to 98.28% and 93.85% respectively. For bacteria and microalgae cells separation, the removal ratio for bacteria and separation efficiency for microalgae cells is 92.69% and 100% respectively. This work demonstrated the continuous and sheathless separation of microalgae from bacteria for the first time by viscoelastic microfluidics. This technique can also be applied as an efficient and user-friendly method to separate mammalian cells or other kinds of cells.
Publisher: American Chemical Society (ACS)
Date: 26-07-2021
Publisher: Springer Science and Business Media LLC
Date: 23-02-2018
DOI: 10.1007/S10544-018-0269-5
Abstract: In this work, a novel double-layer microfluidic device for enhancing particle focusing was presented. The double-layer device consists of a channel with expansion-contraction array and periodical slanted grooves. The secondary flows induced by the grooves modulate the flow patterns in the expansion-contraction-array (ECA) channel, further affecting the particle migration. Compared with the single ECA channel, the double-layer channel can focus the particles over a wider range of flow rate. Due to the differentiation of lateral migration, the double-layer channel is able to distinguish the particles with different sizes. Furthermore, the equilibrium positions could be modulated by the orientation of grooves. This work demonstrates the possibility to enhance and adjust the inertial focusing in an ECA channel with the assistance of grooves, which may provide a simple and portable platform for downstream filtration, separation, and detection.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7LC01076A
Abstract: In this review, we discuss the up-to-date progress of particle migration in viscoelastic fluids mainly from the aspect of applications, laying out a comprehensive perspective on their potential in future lab-on-a-chip platforms.
Publisher: Wiley
Date: 08-10-2020
DOI: 10.1111/JACE.17501
Publisher: American Chemical Society (ACS)
Date: 09-08-2021
Publisher: MDPI AG
Date: 10-07-2022
DOI: 10.3390/BIOS12070505
Abstract: Combined with microfluidics, surface-enhanced Raman spectroscopy (SERS) exhibits huge application prospective in sensitive online detection. In current studies, the design and optimization of plasmonic enhanced structures in microfluidics for SERS detection could be an interesting challenge. In this work, hybrid plasmonic 2D microplates composed of Mxenes (Ti
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0LC00080A
Abstract: The upgraded version of intelligent image-activated cell sorting (iIACS) has enabled higher-throughput and more sensitive intelligent image-based sorting of single live cells from heterogeneous populations.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8LC00047F
Abstract: In this work, we proposed an amalgamation-assisted lithography technique using liquid metal alloys for the fabrication of complex channels with a simple fabrication process, room-temperature fabrication and low toxicity.
No related grants have been discovered for SHENG YAN.