ORCID Profile
0000-0002-0062-9656
Current Organisation
Resyca GmbH
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Turbulent Flows | Interdisciplinary Engineering | Pharmaceutical Sciences |
Respiratory System and Diseases (incl. Asthma) | Expanding Knowledge in the Medical and Health Sciences
Publisher: Springer Science and Business Media LLC
Date: 12-03-2015
Publisher: IOP Publishing
Date: 25-09-2013
Publisher: IOP Publishing
Date: 20-12-2013
Publisher: Elsevier BV
Date: 09-2014
Publisher: Elsevier BV
Date: 2015
Publisher: Springer International Publishing
Date: 18-08-2015
Publisher: Inderscience Publishers
Date: 2009
Publisher: Springer Science and Business Media LLC
Date: 05-02-2011
Publisher: Springer International Publishing
Date: 2015
Publisher: Springer Berlin Heidelberg
Date: 2007
Publisher: Springer International Publishing
Date: 2015
Publisher: American Society of Mechanical Engineers
Date: 25-06-2008
Abstract: This work presents Particle Image Velocimetry (PIV) measurements in idealised and patient specific human carotid artery bifurcations (CAB) under steady and pulsatile flow. The geometry and corresponding boundary conditions were obtained by Magnetic Resonance Imaging (MRI) and replicated in an in-vitro model. A complex three-dimensional flow structure exists inside the CAB and vorticity and wall shear stress data are used to quantify the differences between the idealised and patient specific geometry.
Publisher: AIP Publishing
Date: 02-2014
DOI: 10.1063/1.4866458
Abstract: Here, we detail and analyse a multi-resolution particle image velocity measurement that resolves the wide range of scales prevalent in a zero pressure gradient turbulent boundary layer at high Reynolds numbers (up to Reτ ≈ 20 000). A unique configuration is utilised, where an array of eight high resolution cameras at two magnification levels are used simultaneously to obtain a large field of view, while still resolving the smaller scales prevalent in the flow. Additionally, a highly magnified field of view targeted at the near wall region is employed to capture the viscous sublayer and logarithmic region, with a spatial resolution of a few viscous length scales. Flow statistics from these measurements show good agreement with prior, well resolved hot-wire anemometry measurements. Analysis shows that the instantaneous wall shear stress can be reliably computed, which is historically known to be challenging in boundary layers. A statistical assessment of the wall shear stress shows good agreement with existing correlations, prior experimental and direct numerical simulation data, extending this view to much higher Reynolds numbers. Furthermore, conditional analysis using multiple magnification levels is detailed, to study near-wall events associated with high skin friction fluctuations and their associated overlaying structures in the log region. Results definitively show that the passage of very large-scale positive (or negative) velocity fluctuations are associated with increased (or reduced) small-scale variance in wall shear stress fluctuations.
Publisher: Springer Science and Business Media LLC
Date: 06-2016
Publisher: Springer Science and Business Media LLC
Date: 20-12-2015
Publisher: Springer Science and Business Media LLC
Date: 04-02-2011
Publisher: European Respiratory Society
Date: 09-2017
Publisher: Springer Science and Business Media LLC
Date: 05-2013
Publisher: Elsevier BV
Date: 2006
Publisher: Japan Society of Mechanical Engineers
Date: 2010
DOI: 10.1299/JBSE.5.421
Publisher: Elsevier BV
Date: 2006
Publisher: Springer Science and Business Media LLC
Date: 26-09-2010
Publisher: Springer International Publishing
Date: 2016
Publisher: Informa UK Limited
Date: 23-01-2015
Publisher: Springer Science and Business Media LLC
Date: 10-10-2012
Publisher: American Institute of Aeronautics and Astronautics
Date: 25-06-2012
DOI: 10.2514/6.2012-3115
Publisher: Springer Science and Business Media LLC
Date: 11-2014
Publisher: Springer Science and Business Media LLC
Date: 11-2012
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Springer Science and Business Media LLC
Date: 07-01-2012
Publisher: Springer Science and Business Media LLC
Date: 17-06-2014
DOI: 10.1007/S11095-014-1391-6
Abstract: Non-volatile agents such as glycerol are being introduced into solution-based pMDI formulations in order to control mean precipitant droplet size. To assess their biopharmaceutical efficacy, both microscopic and macroscopic characteristics of the plume must be known, including the effects of external factors such as the flow generated by the patient's inhalation. We test the hypothesis that the macroscopic properties (e.g. spray geometry) of a pMDI spray can be predicted using a self-similarity model, avoiding the need for repeated testing. Glycerol-containing and glycerol-free pMDI formulations with matched mass median aerodynamic diameters are investigated. High-speed schlieren imaging is used to extract time-resolved velocity, penetration and spreading angle measurements of the pMDI spray plume. The experimental data are used to validate the analytical model. The pMDI spray develops in a manner characteristic of a fully-developed steady turbulent jet, supporting the hypothesis. Equivalent glycerol-containing and non glycerol-containing formulations exhibit similar non-dimensional growth rates and follow a self-similar scaling behaviour over a range of physiologically relevant co-flow rates. Using the proposed model, the mean leading edge penetration, velocity and spreading rate of a pMDI spray may be estimated a priori for any co-flow conditions. The effects of different formulations are captured in two scaling constants. This allows formulators to predict the effects of variation between pMDIs without the need for repeated testing. Ultimately, this approach will allow pharmaceutical scientists to rapidly test a number of variables during pMDI development.
Publisher: Springer Science and Business Media LLC
Date: 28-02-2013
Publisher: Springer Science and Business Media LLC
Date: 31-12-2014
Publisher: Springer International Publishing
Date: 18-08-2015
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 04-2022
End Date: 03-2025
Amount: $752,366.00
Funder: Australian Research Council
View Funded Activity