ORCID Profile
0000-0002-2304-8555
Current Organisation
University of Liverpool
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 09-2023
DOI: 10.1111/EVJ.22_13972
Publisher: Oxford University Press (OUP)
Date: 30-09-2023
DOI: 10.1093/OFID/OFAD510
Publisher: Wiley
Date: 09-2023
DOI: 10.1111/EVJ.52_13972
Publisher: Public Library of Science (PLoS)
Date: 12-05-2023
DOI: 10.1371/JOURNAL.PNTD.0011295
Abstract: Despite recognition of histoplasmosis as a disease of national public health concern in Kenya, the burden of Histoplasma capsulatum in the general population remains unknown. This study examined the human seroprevalence of anti- Histoplasma antibody and explored associations between seropositivity and demographic and environmental variables, in Busia county, western Kenya. Biobanked serum s les and associated data, from a previous cross-sectional survey, were examined. Latex agglutination tests to detect the presence of anti- Histoplasma antibody were performed on serum s les from 670 survey respondents, representing 178 households within 102 sub-locations. Potential epidemiologic risk factors for H . capsulatum exposure were explored using multi-level multivariable logistic regression analysis with household and sub-location included as random effects. The apparent s le seroprevalence of anti- Histoplasma antibody was 15.5% ( n = 104/670, 95% Confidence Interval (CI) 12.9–18.5%). A multivariable logistic regression model identified increased odds of H . capsulatum seropositivity in respondents reporting rats within the household within the previous 12 months (OR = 2.99 90% CI 1.04–8.55, p = 0.04). Compared to respondents aged 25–34 years, the odds of seropositivity were higher in respondents aged 15–24 years (OR = 2.70 90% CI 1.04–6.97, p = 0.04). The seroprevalence result provides a baseline for s le size approximations for future epidemiologic studies of the burden of H . capsulatum exposure in Busia county. The final model explored theoretically plausible risk factors for H . capsulatum exposure in the region. A number of factors may contribute to the complex epidemiological picture impacting H . capsulatum exposure status at the human-animal-environment interface in western Kenya. Focussed H . capsulatum research is warranted to determine the contextual significance of identified associations, and in representative s le populations.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Tessa Cornell.