ORCID Profile
0000-0001-6125-5865
Current Organisations
BC Cancer Agency
,
Emory University
,
Queen's University
,
Memorial Sloan Kettering Cancer Center
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Publisher: Springer Science and Business Media LLC
Date: 06-06-2016
DOI: 10.1038/NCOMMS11908
Abstract: Nature Communications 7 Article number:11479 (2016) Published: 10 May 2016 Updated: 6 June 2016. The original version of this Article contained an error in the spelling of ‘refine’ in the title of the paper. This has now been corrected in both the PDF and HTML.
Publisher: Springer Science and Business Media LLC
Date: 27-07-2010
Publisher: Springer Science and Business Media LLC
Date: 16-05-2012
DOI: 10.1038/NATURE11017
Publisher: Springer Science and Business Media LLC
Date: 09-2010
Publisher: Springer Science and Business Media LLC
Date: 18-04-2012
DOI: 10.1038/NATURE10983
Publisher: Massachusetts Medical Society
Date: 14-10-2010
Publisher: Springer Science and Business Media LLC
Date: 10-05-2016
DOI: 10.1038/NCOMMS11479
Abstract: The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-term clinical follow-up data. We identify 40 mutation-driver (Mut-driver) genes, and determine associations between mutations, driver CNA profiles, clinical-pathological parameters and survival. We assess the clonal states of Mut-driver mutations, and estimate levels of intra-tumour heterogeneity using mutant-allele fractions. Associations between PIK3CA mutations and reduced survival are identified in three subgroups of ER-positive cancer (defined by lification of 17q23, 11q13–14 or 8q24). High levels of intra-tumour heterogeneity are in general associated with a worse outcome, but highly aggressive tumours with 11q13–14 lification have low levels of intra-tumour heterogeneity. These results emphasize the importance of genome-based stratification of breast cancer, and have important implications for designing therapeutic strategies.
Location: United States of America
No related grants have been discovered for Gulisa Turashvili.