ORCID Profile
0000-0003-4232-871X
Current Organisations
Montreal Children's Hospital
,
Université McGill
,
Research Institute of the McGill University Health Centre
,
McGill University Health Centre
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Publications
Evaluation of Serological Diagnostic Methods for the 2009 Pandemic Influenza A (H1N1) Virus
Publisher: American Society for Microbiology
Date: 03-2011
DOI: 10.1128/CVI.00449-10
Abstract: Serology improves influenza diagnosis by capturing cases missed by reverse transcriptase PCR (RT-PCR). We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 influenza A (H1N1) virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance with RT-PCR (kappa = 0.69 versus kappa = 0.60) and greater sensitivity (83% versus 71% P = 0.016).
Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants
Publisher: Massachusetts Medical Society
Date: 30-07-2020
Seroconversion to Seasonal Influenza Viruses after A(H1N1)pdm09 Virus Infection, Quebec, Canada
Publisher: Centers for Disease Control and Prevention (CDC)
Date: 08-2012
Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis
Publisher: Massachusetts Medical Society
Date: 03-12-2009
DOI: 10.1056/NEJMC0910060
Global molecular diversity of RSV – the “INFORM RSV” study
Publisher: Springer Science and Business Media LLC
Date: 26-06-2020
DOI: 10.1186/S12879-020-05175-4
Abstract: Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular ersity of RSV isolates collected from children less than 5 years of age. The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of 4000 RSV-positive respiratory s les is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of s les to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies. The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.
Presence of Oseltamivir-Resistant Pandemic A/H1N1 Minor Variants Before Drug Therapy With Subsequent Selection and Transmission
Publisher: Oxford University Press (OUP)
Date: 10-09-2012
Household Transmission of the 2009 Pandemic A/H1N1 Influenza Virus: Elevated Laboratory‐Confirmed Secondary Attack Rates and Evidence of Asymptomatic Infections
Publisher: Oxford University Press (OUP)
Date: 11-2010
DOI: 10.1086/656582
Abstract: Characterizing household transmission of the 2009 pandemic A/H1N1 influenza virus (pH1N1) is critical for the design of effective public health measures to mitigate spread. Our objectives were to estimate the secondary attack rates (SARs), the proportion of asymptomatic infections, and risk factors for pH1N1 transmission within households on the basis of active clinical follow-up and laboratory-confirmed outcomes. We conducted a prospective observational study during the period May-July 2009 (ie, during the first wave of the pH1N1 pandemic) in Quebec City, Canada. We assessed pH1N1 transmission in 42 households (including 43 primary case patients and 119 contacts). Clinical data were prospectively collected during serial household visits. Secondary case patients were identified by clinical criteria and laboratory diagnostic tests, including serological and molecular methods. We identified 53 laboratory-confirmed secondary case patients with pH1N1 virus infection, for an SAR of 45% (95% confidence interval [CI], 35.6%-53.5%). Thirty-four (81%) of the households had ≥1 confirmed secondary case patient. The mean serial interval between onset of primary and confirmed secondary cases was 3.9 days (median interval, 3 days). Influenza-like illness (fever and cough or sore throat) developed in 29% (95% CI, 20.5%-36.7%) of household contacts. Five (9.4%) of secondary case patients were asymptomatic. Young children (<7 years of age) were at highest risk of developing laboratory-confirmed influenza-like illness. Primary case patients with both diarrhea and vomiting were the most likely to transmit pH1N1. Household transmission of pH1N1 may be substantially greater than previously estimated, especially in association with clinical presentations that include gastrointestinal complaints. Approximately 10% of pH1N1 infections acquired in the household may be asymptomatic.
Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series
Publisher: Elsevier BV
Date: 10-2017
Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data
Publisher: Elsevier BV
Date: 07-2023
Related Organisations
Research Institute Of The McGill University Health Centre
Location: Canada
Related Funding Activities
No related grants have been discovered for Jesse Papenburg.