ORCID Profile
0000-0001-6996-3663
Current Organisation
The University of Edinburgh
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Physical Society (APS)
Date: 15-11-2021
Publisher: American Physical Society (APS)
Date: 02-12-2022
Publisher: American Physical Society (APS)
Date: 18-05-2020
Publisher: American Physical Society (APS)
Date: 25-10-2201
Publisher: American Physical Society (APS)
Date: 04-06-2021
Publisher: American Physical Society (APS)
Date: 16-03-2023
Publisher: American Physical Society (APS)
Date: 04-03-2022
Publisher: American Physical Society (APS)
Date: 02-05-2022
Publisher: American Physical Society (APS)
Date: 07-02-0005
Publisher: American Physical Society (APS)
Date: 04-12-2020
Publisher: Springer Science and Business Media LLC
Date: 2014
Publisher: IOP Publishing
Date: 08-2020
Abstract: A compact detector for space-time metric and curvature is highly desirable. Here we show that quantum spatial superpositions of mesoscopic objects could be exploited to create such a detector. We propose a specific form for such a detector and analyse how asymmetries in its design allow it to directly couple to the curvature. Moreover, we also find that its non-symmetric construction and the large mass of the interfered objects, enable the detection gravitational waves (GWs). Finally, we discuss how the construction of such a detector is in principle possible with a combination of state of the art techniques while taking into account the known sources of decoherence and noise. To this end, we use Stern–Gerlach interferometry with masses ∼10 −17 kg, where the interferometric signal is extracted by measuring spins and show that accelerations as low as 5 × 10 −15 ms −2 Hz −1/2 , as well as the frame dragging effects caused by the Earth, could be sensed. The GW sensitivity scales differently from the stray acceleration sensitivity, a unique feature of the proposed interferometer. We identify mitigation mechanisms for the known sources of noise, namely gravity gradient noise, uncertainty principle and electro-magnetic forces and show that it could potentially lead to a metre sized, orientable and vibrational noise (thermal/seismic) resilient detector of mid (ground based) and low (space based) frequency GWs from massive binaries (the predicted regimes are similar to those targeted by atom interferometers and LISA).
Publisher: IOP Publishing
Date: 28-07-2009
Publisher: American Physical Society (APS)
Date: 08-02-2017
Publisher: Springer Science and Business Media LLC
Date: 24-01-2020
DOI: 10.1038/S41467-019-14224-9
Abstract: Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS G13D ) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping PPIs shows that this network is extensively rewired in cells expressing transforming levels of KRAS G13D (mtKRAS). The factors driving PPIN rewiring are multifactorial including changes in protein expression and phosphorylation. Mathematical modelling also suggests that the binding dynamics of low and high affinity KRAS interactors contribute to rewiring. PPIN rewiring substantially alters the composition of protein complexes, signal flow, transcriptional regulation, and cellular phenotype. These changes are validated by targeted and global experimental analysis. Importantly, genetic alterations in the most extensively rewired PPIN nodes occur frequently in CRC and are prognostic of poor patient outcomes.
Publisher: American Physical Society (APS)
Date: 15-08-2022
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Steven Shave.