ORCID Profile
0000-0003-4238-1510
Current Organisation
Julius-Maximilians-Universität Würzburg
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Publisher: American Chemical Society (ACS)
Date: 22-12-2005
DOI: 10.1021/LA047802I
Abstract: Aspirin and 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) are deposited from their alcoholic mixed solution onto highly oriented pyrolytic graphite (HOPG) by spin coating. The film structure and morphology are characterized by atomic force microscopy (AFM). The barely soluble DMPE forms a highly oriented stripe phase as a result of its one-dimensional epitaxy with the HOPG lattice. The bilayer stripe pattern exposes the cross section of the lipid bilayer lamellae and enables the direct visualization of the molecular interactions of drug or biological molecules with either the hydrophobic or the hydrophilic part of the phospholipid bilayer. The bilayer pattern affects the aspirin molecular deposition and aggregation. AFM shows that the aspirin molecules prefer to deposit and aggregate along the aliphatic interior part of the bilayer pattern, giving rise to parallel dimer rods in registry with the underlying pattern. The nonpolar interactions between aspirin and the phospholipid bilayer are consistent with the lipophilic nature of aspirin. The bilayer pattern not only stabilizes the rodlike aggregate structure of aspirin at low aspirin concentration but also inhibits crystallization of aspirin at high aspirin concentration. Molecular models show that the width of the DMPE aliphatic chain interior can accommodate no more than two aspirin dimers. The bilayer confinement may prevent aspirin from reaching its critical nucleus size. This study illustrates a general method to induce a metastable or amorphous form of an active pharmaceutical ingredient (API) by chemical confinement under high undercooling conditions. Metastable and amorphous solids often display better solubility and bioavailability than the stable crystalline form of the API.
Publisher: American Chemical Society (ACS)
Date: 10-09-2005
DOI: 10.1021/CM051090F
Publisher: Wiley
Date: 02-03-2005
Publisher: American Chemical Society (ACS)
Date: 25-06-2019
DOI: 10.1021/ACS.INORGCHEM.9B00698
Abstract: Since the initial report by Lehn et al. in 1979, ruthenium tris(bipyridine) ([Ru(bpy)
Publisher: American Chemical Society (ACS)
Date: 14-10-2005
DOI: 10.1021/LA051638X
Abstract: In the current work we demonstrate a facile and versatile way to create hydrophilic polymeric capsules by integration of Au nanocrystal templating, surface-initiated atom-transfer radical polymerization, and selective chemical cross-linking of polymer shells. Capsules of the homopolymer of 2-(dimethylamino)ethyl methacrylate and its copolymers with 2-(diethylamino)ethyl methacrylate and poly(ethylene glycol) methyl ether methacrylate were constructed. They swell at low pH and shrink at high pH. On the basis of the pH sensitivity of the resulting capsules, encapsulation and release of a drug model, rhodamine 6G, were realized. Furthermore, by cleaving Au-S bonds between Au cores and polymer shells, capsules containing free Au cores were generated, paving a simple pathway to introduce more functionality to the polymeric capsules.
Publisher: Wiley
Date: 20-10-2004
Publisher: American Chemical Society (ACS)
Date: 15-01-2004
DOI: 10.1021/NL034966V
Publisher: American Chemical Society (ACS)
Date: 23-04-2005
DOI: 10.1021/NL0505391
Abstract: Based on the interfacial self-assembly of magnetite nanoparticles, we demonstrate the formation of colloidosomes with shells predominantly composed of monolayers of liquid-like, close-packed nanoparticles. The gelation of aqueous phase with agarose leads to robust and water-dispersible nanoparticle colloidosomes, allowing encapsulation of various water soluble materials. The cutoff of the nanoparticle colloidosomes obtained is primarily defined by the nanoparticle size. This controllable permeability should be of great importance for the encapsulation application.
No related grants have been discovered for Dirk Kurth.