ORCID Profile
0000-0002-4695-2184
Current Organisations
University of Sheffield
,
University of Nottingham
,
University of South Florida
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Publisher: Elsevier BV
Date: 03-2015
Publisher: Acoustical Society of America (ASA)
Date: 31-07-2002
DOI: 10.1121/1.1490352
Abstract: The effect on gap detectability of varying noise fall time (FT) and rise time (RT) of the gap boundary r s was examined in mice using reflex modification audiometry, measuring inhibition of acoustic startle reflexes by variously shaped gaps just preceding reflex expression. In experiment 1 (n=12) inhibition increased up to near-asymptotic values with longer FT (0, 1, 2, 3, 5, or 10 ms) and QT (quiet time, 0 to 13 ms), with a 2:1 trade-off between FT and QT. In experiment 2 (n=24) inhibition increased for any RT above 0 ms (2, 3, 5, or 7 ms) if QT=1 ms, but diminished with increased RT when QT=3 or 8 ms. Enhanced detectability for subthreshold gaps by longer r s results from their extending the apparent gap duration. The negative effect of increased RT for threshold gaps suggests the importance for gap detection of the stronger neural responses to sharp edges at the end of the gap shown previously in the mouse inferior colliculus. These effects are specific to gaps: inhibition for fixed (70-dB SPL) or varied level pulses (30 to 60 dB) was unaffected by varying the r ed edges (experiments 3 and 4, n=9).
Publisher: BMJ
Date: 05-2008
Publisher: Elsevier BV
Date: 12-2003
DOI: 10.1016/S0378-5955(03)00300-9
Abstract: Age-related deterioration of auditory temporal acuity has been identified as a contributing factor in presbycusis. In the present study, the effects of aging and stimulus level on gap encoding and gap recovery functions were investigated by measuring near-field auditory evoked potentials in the inferior colliculus of eight 3 month old and eight 24 month old CBA/CaJ mice, in response to gap stimuli embedded in broadband noise (40, 60, and 80 dB SPL). Gap encoding was assessed by measuring latencies and litudes of peak features of the near-field response, and also with a procedure that calculated the root mean square of the response within specific time windows. The chief differences in gap encoding between young and old mice were longer gap thresholds, slower recovery functions, and longer response peak latencies for old mice at 60, but not 80 dB SPL, although the latency of the earliest measured peak remained delayed for this condition in the old compared with the young mice. These results demonstrate that age-related changes in temporal acuity may interact with stimulus level, and suggest that adequate lification may be critically important for maintaining temporal acuity with advancing age.
Publisher: Elsevier BV
Date: 12-2008
Publisher: Elsevier BV
Date: 2011
DOI: 10.1016/J.NEUROBIOLAGING.2009.01.006
Abstract: Reduced frequency selectivity is associated with an age-related decline in speech recognition in background noise and reverberant environments. To elucidate neural correlates of age-related alteration in frequency selectivity, the present study examined frequency response areas (FRAs) of multi-unit clusters in the inferior colliculus of young, middle-aged, and old CBA/CaJ mice. The FRAs in middle-aged and old mice were found to be broader and more asymmetric in shape. In addition to a decrease of closed/complex FRAs in both middle age and old groups, there was a transient decrease in V-shaped FRAs and a concomitant increase in multipeak FRAs in middle age. Intensity coding was also affected by age, as observed in an increase of monotonic responses in middle-aged and old mice. While a decline in low-level activity began in middle age, reduced driven rates at suprathreshold levels occurred later in old age. Collectively, these results support the view that aging alters frequency selectivity by widening excitatory FRAs and that these changes begin to appear in middle age.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Emma Wilson.