ORCID Profile
0000-0001-6921-3870
Current Organisations
McGill University
,
Douglas Mental Health University Institute
,
Revivre
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Publisher: Consortium Erudit
Date: 25-03-2008
DOI: 10.7202/017808AR
Abstract: Grâce à une subvention des Instituts de recherche en santé du Canada (IRSC), il se développe actuellement une nouvelle génération d’études en épidémiologie sociale et psychiatrique dans une zone circonscrite se situant dans le sud-ouest de Montréal où vivent 258 000 personnes. Ce programme de recherche repose sur une étude prospective longitudinale visant à identifier les déterminants de la santé mentale de la population, et sur quatre études spécifiques qui abordent des paramètres importants pour la santé mentale : l’écologie sociale et physique des quartiers, le soutien social, le stigma social et les services en santé mentale. Ce programme est complété par l’utilisation de la dernière génération des outils technologiques et informatiques soit un système d’information géographique (SIG) qui permet d’apprécier les effets du contexte sur la santé mentale. Les bases théoriques sur lesquels repose ce modèle sont présentées de même qu’une description sommaire des méthodes utilisées.
Publisher: Wiley
Date: 10-01-2008
DOI: 10.1111/J.1399-5618.2007.00556.X
Abstract: The Diagnostic Guidelines Task Force of the International Society for Bipolar Disorders (ISBD) presents in this document and this special issue a summary of the current nosological status of bipolar illness, a discussion of possible revisions to current DSM-IV and ICD-10 definitions, an examination of the relevant literature, explication of areas of consensus and dissensus, and proposed definitions that might guide clinicians in the most valid approach to diagnosis of these conditions given the current state of our knowledge.
Publisher: Wiley
Date: 11-2011
DOI: 10.1111/J.1399-5618.2011.00959.X
Abstract: Murray G, Lam RW, Beaulieu S, Sharma V, Cervantes P, Parikh SV, Yatham LN. Do symptoms of bipolar disorder exhibit seasonal variation? A multisite prospective investigation. Bipolar Disord 2011: 13: 687–695. © 2011 The Authors. Journal compilation © 2011 John Wiley & Sons A/S. Objectives: Evidence that symptoms of bipolar disorder (BD) vary seasonally is inconclusive. Here, a multisite prospective investigation of patients with BD was used to test the hypothesis that, on average, depressive symptoms peak in autumn/winter and hypo/manic symptoms peak in spring/summer. Secondary analyses explored gender and diagnosis [bipolar I disorder (BD‐I) versus bipolar II disorder (BD‐II)] effects on seasonality. Methods: A s le of 429 patients with BD (61.6% female 56.2% BD‐I) were recruited from 12 sites across Canada. Clinician‐rated measures of manic [Young Mania Rating Scale (YMRS), n = 4,753 total observations] and depression symptoms [Montgomery‐Åsberg Depression Rating Scale (MADRS), n = 4,691 observations] were taken at scheduled three‐month visits as well as any unscheduled visits. At scheduled visits only, Hamilton Depression Rating Scale (Ham‐D) assessments (n = 3,153 observations) were also made. Multi‐level modeling (MLM) analyses were conducted separately for the three dependent variables and three definitions of Time : calendar month, nominal season, and harmonic analysis. Results: Primary analyses of the whole s le found that for manic symptoms (YMRS), neither calendar month nor nominal season were significant, and harmonic analyses found an unpredicted frequency two sinusoid, with peaks at 4 th December and 4 th June (p 0.018). Secondary analyses found that this sinusoid approximately fit the YMRS data for females and those diagnosed with BD‐II. For depression symptoms measured on the MADRS and Ham‐D, no significant seasonal patterns were found in primary analyses of the whole s le. Secondary analyses found a significant increase in MADRS scores in November/December among females, but this pattern was not corroborated in nominal season or harmonic analyses. Conclusions: No evidence of systematic seasonal variation in symptoms was found in the s le as a whole. Primary analyses found no evidence that hypo/manic symptoms peaked in the lighter months and depressive symptoms peaked in the darker months. The present findings align with broadly negative conclusions from three earlier prospective investigations, and provide the strongest evidence to date that seasonal changes do not in fact cause coordinated variation in BD symptoms.
Publisher: Cambridge University Press (CUP)
Date: 18-09-2017
DOI: 10.1017/S0033291717002495
Abstract: Although quality of life (QoL) is receiving increasing attention in bipolar disorder (BD) research and practice, little is known about its naturalistic trajectory. The dual aims of this study were to prospectively investigate: (a) the trajectory of QoL under guideline-driven treatment and (b) the dynamic relationship between mood symptoms and QoL. In total, 362 patients with BD receiving guideline-driven treatment were prospectively followed at 3-month intervals for up to 5 years. Mental (Mental Component Score – MCS) and physical (Physical Component Score – PCS) QoL were measured using the self-report SF-36. Clinician-rated symptom data were recorded for mania and depression. Multilevel modelling was used to analyse MCS and PCS over time, QoL trajectories predicted by time-lagged symptoms, and symptom trajectories predicted by time-lagged QoL. MCS exhibited a positive trajectory, while PCS worsened over time. Investigation of temporal relationships between QoL and symptoms suggested bidirectional effects: earlier depressive symptoms were negatively associated with mental QoL, and earlier manic symptoms were negatively associated with physical QoL. Importantly, earlier MCS and PCS were both negatively associated with downstream symptoms of mania and depression. The present investigation illustrates real-world outcomes for QoL under guideline-driven BD treatment: improvements in mental QoL and decrements in physical QoL were observed. The data permitted investigation of dynamic interactions between QoL and symptoms, generating novel evidence for bidirectional effects and encouraging further research into this important interplay. Investigation of relevant time-varying covariates (e.g. medications) was beyond scope. Future research should investigate possible determinants of QoL and the interplay between symptoms and wellbeing/satisfaction-centric measures of QoL.
Location: United States of America
No related grants have been discovered for Serge Beaulieu.