ORCID Profile
0000-0002-6489-5988
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Medicinal and Biomolecular Chemistry | Synthesis Of Macromolecules | Theoretical and Computational Chemistry not elsewhere classified | Functional Materials | Biological And Medical Chemistry | Optical Properties of Materials | Macromolecular and Materials Chemistry | Chemistry Of Catalysis | Proteins and Peptides | Nonlinear Optics and Spectroscopy | Molecular and Organic Electronics |
Expanding Knowledge in the Chemical Sciences | Hearing, vision, speech and their disorders | Expanding Knowledge in the Physical Sciences | Waste management and recycling | Chemical sciences
Publisher: Wiley
Date: 25-07-2019
Publisher: American Chemical Society (ACS)
Date: 19-11-2021
Publisher: Wiley
Date: 08-04-2015
Abstract: A smart and reversibly photoswitchable membrane based on an azobenzene photo-switch containing peptides attached inside the pores of nanoporous anodic alumina membranes (NAAMs) is presented. The transport of molecules of interest across the photoswitchable peptide (PSP) functionalized NAAMs can be effectively controlled and manipulated as a function of the photostationary state of the azobenzene group in a PSP.
Publisher: Informa UK Limited
Date: 2008
Publisher: Portland Press Ltd.
Date: 10-06-2020
DOI: 10.1042/BCJ20200290
Abstract: Amyloid beta peptide (Aβ42) aggregation in the brain is thought to be responsible for the onset of Alzheimer's disease, an insidious condition without an effective treatment or cure. Hence, a strategy to prevent aggregation and subsequent toxicity is crucial. Bio-inspired peptide-based molecules are ideal candidates for the inhibition of Aβ42 aggregation, and are currently deemed to be a promising option for drug design. In this study, a hexapeptide containing a self-recognition component unique to Aβ42 was designed to mimic the β-strand hydrophobic core region of the Aβ peptide. The peptide is comprised exclusively of D-amino acids to enhance specificity towards Aβ42, in conjunction with a C-terminal disruption element to block the recruitment of Aβ42 monomers on to fibrils. The peptide was rationally designed to exploit the synergy between the recognition and disruption components, and incorporates features such as hydrophobicity, β-sheet propensity, and charge, that all play a critical role in the aggregation process. Fluorescence assays, native ion-mobility mass spectrometry (IM-MS) and cell viability assays were used to demonstrate that the peptide interacts with Aβ42 monomers and oligomers with high specificity, leading to almost complete inhibition of fibril formation, with essentially no cytotoxic effects. These data define the peptide-based inhibitor as a potentially potent anti-amyloid drug candidate for this hitherto incurable disease.
Publisher: American Chemical Society (ACS)
Date: 04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2006
DOI: 10.1039/B611016A
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3AN01933K
Publisher: Elsevier BV
Date: 07-2008
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B716284G
Publisher: American Chemical Society (ACS)
Date: 10-02-2021
Publisher: Elsevier BV
Date: 02-2013
Publisher: American Chemical Society (ACS)
Date: 14-06-2008
DOI: 10.1021/JA801142K
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7RA07753J
Abstract: A controllable mechanistic transition of charge transfer in helical peptides is demonstrated as a direct result of side-bridge gating.
Publisher: Wiley
Date: 07-07-2020
Publisher: American Chemical Society (ACS)
Date: 20-08-2014
DOI: 10.1021/JA507175B
Publisher: American Chemical Society (ACS)
Date: 07-09-2018
DOI: 10.1021/ACS.ACCOUNTS.8B00198
Abstract: Molecular electronics is at the forefront of interdisciplinary research, offering a significant extension of the capabilities of conventional silicon-based technology as well as providing a possible stand-alone alternative. Bio-inspired molecular electronics is a particularly intriguing paradigm, as charge transfer in proteins eptides, for ex le, plays a critical role in the energy storage and conversion processes for all living organisms. However, the structure and conformation of even the simplest protein is extremely complex, and therefore, synthetic model peptides comprising well-defined geometry and predetermined functionality are ideal platforms to mimic nature for the elucidation of fundamental biological processes while also enhancing the design and development of single-peptide electronic components. In this Account, we first present intramolecular electron transfer within two synthetic peptides, one with a well-defined helical conformation and the other with a random geometry, using electrochemical techniques and computational simulations. This study reveals two definitive electron transfer pathways (mechanisms), the natures of which are dependent on secondary structure. Following on from this, electron transfer within a series of well-defined helical peptides, constrained by either Huisgen cycloaddition, ring-closing metathesis, or a lactam bridge, was determined. The electrochemical results indicate that each constrained peptide, in contrast to a linear counterpart, exhibits a remarkable shift of the formal potential to the positive (>460 mV) and a significant reduction of the electron transfer rate constant (up to 15-fold), which represent two distinct electronic "on/off" states. High-level calculations demonstrate that the additional backbone rigidity provided by the side-bridge constraints leads to an increased reorganization energy barrier, which impedes the vibrational fluctuations necessary for efficient intramolecular electron transfer through the peptide backbone. Further calculations reveal a clear mechanistic transition from hopping to superexchange (tunneling) stemming from side-bridge gating. We then extended our research to fine-tuning of the electronic properties of peptides through both structural and chemical manipulation, to reveal an interplay between electron-rich side chains and backbone rigidity on electron transfer. Further to this, we explored the possibility that the side-bridge constraints present in our synthetic peptides provide an additional electronic transport pathway, which led to the discovery of two distinct forms of quantum interferometer. The effects of destructive quantum interference appear essentially through both the backbone and an alternative tunneling pathway provided by the side bridge in the constrained β-strand peptide, as evidenced by a correlation between electrochemical measurements and conductance simulations for both linear and constrained β-strand peptides. In contrast, an interplay between quantum interference effects and vibrational fluctuations is revealed in the linear and constrained 3
Publisher: Elsevier BV
Date: 11-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B615096A
Abstract: A new approach for the attachment of vertically-aligned shortened carbon nanotube architectures to a silicon (100) substrate by chemical anchoring directly to the surface has been demonstrated for the first time. The ordered assembly of single-walled carbon nanotubes (SWCNTs) was accomplished by hydroxylating the silicon surface followed by a condensation reaction with carboxylic acid functionalised SWCNTs. This new nanostructure has been characterised by X-ray photoelectron, Raman and Fourier transform infrared (FTIR) spectroscopy as well as scanning electron and atomic force microscopy. The assembly behaviour of SWCNTs onto the silicon surface shows a fast initial step producing isolated functionalised carbon nanotubes or nanotube bundles anchored to the silicon surface followed by a slower step where the adsorbed nanotubes grow into larger aggregates via van der Waals interactions between adsorbed and solvated nanotubes. The electrochemical and optical properties of the SWCNTs directly attached to silicon have also been investigated. These new nanostructures are excellent electrochemical electrodes. They also fluoresce in the wavelength range 650-800 nm. The successful attachment of the SWCNTs directly to silicon provides a simple, new avenue for fabrication and development of silicon-based nanoelectronic, nano-optoelectronic and sensing devices. Compared to existing techniques, this new approach has several advantages including low operating temperature, low cost and the possibility of further modification.
Publisher: American Chemical Society (ACS)
Date: 15-06-2020
Publisher: IOP Publishing
Date: 26-09-2008
DOI: 10.1088/0957-4484/19/44/445301
Abstract: A monolayer of hexadecyltrichlorosilane, 3-aminopropyltriethoxysilane or 3-mercaptopropyltrimethoxysilane was self-assembled onto a p-type silicon (100) substrate to provide a resist for electrochemical anodization with an atomic force microscope cantilever. Silane treatment of the oxide nanostructures created by anodization lithography allowed for the creation of a chemically heterogeneous surface, containing regions of -NH(2) or -SH surrounded by -CH(3) functionality. These patterned regions of -NH(2) or -SH provided the point of attachment for citrate-stabilized gold colloid nanoparticles, which act as 'seed' particles for the electro-less deposition of gold. This has allowed the creation of gold wires on a silicon surface. Carbon nanotubes, with high carboxylic acid functionality, were vertically immobilized on the patterned gold wires with the use of a cysteamine monolayer and a condensation reaction. Such a material may prove useful in the creation of future vertically integrated electronic devices where it is desirable for electron transport to be in three dimensions and this electron transport is demonstrated with cyclic voltammetry.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR04871A
Abstract: Pseudocapacitance, which is the storage of charge based on continuous and fast reversible redox reactions at the surface of the electrodes, is commonly observed in transition metal oxide based LIB anodes.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TA02689A
Abstract: DAAP@C with stable amide bond (–CO–NH–) between carbon fibers and DAAP molecules has excellent electronic conductivity, insolubility and electrochemical performance. The fatal problems of small molecule carbonyl compounds were solved.
Publisher: American Chemical Society (ACS)
Date: 28-11-2019
Abstract: The primary sequence and secondary structure of a peptide are crucial to charge migration, not only in solution (electron transfer, ET), but also in the solid-state (electron transport, ETp). Hence, understanding the charge migration mechanisms is fundamental to the development of biomolecular devices and sensors. We report studies on four Aib-containing helical peptide analogues: two acyclic linear peptides with one and two electron-rich alkene-based side chains, respectively, and two peptides that are further rigidified into a macrocycle by a side bridge constraint, containing one or no alkene. ETp was investigated across Au eptide/Au junctions, between 80 and 340 K in combination with the molecular dynamic (MD) simulations. The results reveal that the helical structure of the peptide and electron-rich side chain both facilitate the ETp. As temperature increases, the loss of helical structure, change of monolayer tilt angle, and increase of thermally activated fluctuations affect the conductance of peptides. Specifically, room temperature conductance across the peptide monolayers correlates well with previously observed ET rate constants, where an interplay between backbone rigidity and electron-rich side chains was revealed. Our findings provide new means to manipulate electronic transport across solid-state peptide junctions.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CP00635A
Abstract: We provide evidence that bound zinc promotes electron transfer in a peptide by changing the electronic properties of the peptide.
Publisher: American Scientific Publishers
Date: 07-2014
Publisher: Elsevier BV
Date: 03-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CC16665H
Abstract: The mechanism of electron transfer in α-aminoisobutyric (Aib) homoligomers is defined by the extent of secondary structure, rather than just chain length. Helical structures (Aib units ≥3) undergo an electron hopping mechanism, while shorter disordered sequences (Aib units <3) undergo an electron superexchange mechanism.
Publisher: Wiley
Date: 15-11-2018
Abstract: Gramicidin S is a naturally occurring antimicrobial cyclic peptide. Herein, we present a series of cyclic peptides based on gramicidin S that contain an azobenzene photoswitch to reversibly control secondary structure and, hence, antimicrobial activity.
Publisher: American Chemical Society (ACS)
Date: 06-12-2012
DOI: 10.1021/JP3082563
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B809609K
Publisher: American Chemical Society (ACS)
Date: 18-12-2019
Abstract: The shuttling phenomena in lithium-sulfur batteries lead to drastic attenuation of the capacity. This can be suppressed effectively by modifying the separator. Herein, a double-layered separator composed of a macroporous polypropylene (PP) matrix layer and an arrayed poly(methyl methacrylate) (PMMA) microsphere retarding layer is designed as the separator for lithium-sulfur batteries. A sulfur positive electrode with the PP/PMMA separator exhibits a high initial capacity of 1100.10 mAh g
Publisher: Elsevier BV
Date: 06-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2MH00075J
Abstract: This is a comprehensive review of the electrochemical synthesis of nano/microstructure transition metal-based materials for oxygen evolution reaction from the aspects of ‘Fundamentals, Structural design and Classification’.
Publisher: American Chemical Society (ACS)
Date: 13-08-2019
DOI: 10.1021/ACSCHEMBIO.9B00463
Abstract: Here, we report the design, synthesis, and evaluation of a series of inhibitors of
Publisher: Wiley
Date: 05-2015
Publisher: Elsevier BV
Date: 04-2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3CC47885H
Abstract: Two helical peptides, one constrained by a covalent side-chain staple, exhibit vastly different electronic properties despite adopting essentially the same backbone conformation. High level calculations confirm that these differences are due to the additional backbone rigidity imparted by the macrocyclic constraint.
No related organisations have been discovered for Jingxian Yu.
Start Date: 07-2009
End Date: 10-2013
Amount: $350,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 05-2018
End Date: 12-2023
Amount: $416,584.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2011
End Date: 12-2011
Amount: $300,000.00
Funder: Australian Research Council
View Funded Activity