ORCID Profile
0000-0003-0288-8608
Current Organisations
Isfahan University of Technology
,
RMIT University
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Civil Engineering | Urban and Regional Planning not elsewhere classified | Structural Engineering | Construction Materials |
Environmentally Sustainable Manufacturing not elsewhere classified | Environmentally Sustainable Construction not elsewhere classified
Publisher: Elsevier
Date: 2004
Publisher: Wiley
Date: 13-10-2020
DOI: 10.1002/MDS3.10127
Publisher: American Chemical Society
Date: 2012
Publisher: Elsevier BV
Date: 06-2022
Publisher: Department of Polymer Engineering, Scientific Society of Mechanical Engineering
Date: 2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2PY00529H
Publisher: Wiley
Date: 29-12-2015
DOI: 10.1002/JBM.A.35620
Abstract: In the current study, we describe the synthesis, material characteristics, and cytocompatibility of conducting poly (ɛ-caprolactone) (PCL)-based nano-composite films. Electrically conducting carbon nano-fillers (carbon nano-fiber (CNF), nano-graphite (NG), and liquid exfoliated graphite (G)) were used to prepare porous film type scaffolds using modified solvent casting methods. The electrical conductivity of the nano-composite films was increased when carbon nano-fillers were incorporated in the PCL matrix. CNF-based nano-composite films showed the highest increase in electrical conductivity. The presence of an ionic solution significantly improved the conductivity of some of the polymers, however at least 24 h was required to absorb the simulated ion solutions. CNF-based nano-composite films were found to have good thermo-mechanical properties compared to other conducting polymer films due to better dispersion and alignment in the critical direction. Increased nano-filler content increased the crystallisation temperature. Analysis of cell viability revealed no increase in cell death on any of the polymers compared to tissue culture plastic controls, or compared to PCL polymer without nano-composites. The scaffolds showed some variation when tested for PC12 cell attachment and proliferation, however all the polymers supported PC12 attachment and differentiation in the absence of cell adhesion molecules. In general, CNF-based nano-composite films with highest electrical conductivity and moderate roughness showed highest cell attachment and proliferation. These polymers are promising candidates for use in neural applications in the area of bionics and tissue engineering due to their unique properties.
Publisher: Wiley
Date: 14-01-2005
Publisher: SAGE Publications
Date: 14-03-2018
Abstract: This research investigated the transport properties (such as thermal resistance, water vapor resistance and air permeability), moisture management capacity and sensorial properties of some knitted structures of superabsorbent polyacrylate in order to explore their potential as next-to-skin layers in firefighters’ protective clothing in Australia. Test results using these fabrics were compared with the currently used next-to-skin woven fabric. Three different knitted structures (i.e. jersey, rib and interlock) were selected for the study in addition to the current woven fabric in use by Australian firefighters. It was observed that the knitted fabric s les of superabsorbent polyacrylate retained higher amounts of water compared to the fabric s le currently used in the firefighters’ clothing. However, the woven fabric s le dried at a faster rate. Hence, a blended fabric of polyacrylate with the current Nomex® fabric can help in higher sweat absorption and faster drying. The thermal and water vapor resistance of jersey fabric was the lowest, which may better facilitate the transfer of metabolic heat and vapor to the environment, resulting in better thermal comfort. Furthermore, all the fabric s les showed a low coefficient of friction (∼0.2), which indicated less tactile discomfort if the fabrics are worn as the next-to-skin layer in the firefighters’ clothing. The overall moisture management properties of the fabric s les were rated as fair to good. The findings of this research suggest that the superabsorbent material has the potential to be used in place of the existing next-to-skin layer of firefighters’ protective clothing, with better sweat absorption capacity and thermal comfort.
Publisher: SPIE
Date: 30-12-2019
DOI: 10.1117/12.2539276
Publisher: American Chemical Society (ACS)
Date: 30-06-2021
Publisher: Wiley
Date: 25-07-2023
Abstract: Zein, which accounts for around 80% of the total protein composition in corn, is a biocompatible and biodegradable substance derived from renewable sources. Although insoluble in water, its hiphilic characteristics are utilized to generate nanoparticles, nanofibers, microparticles, and even films. Numerous recent studies have demonstrated the potential of zein as a prospective biomaterial to develop fibrous scaffolds for biomedical functions owing to its biocompatibility, fibrous formation, and encapsulating qualities. Fabrication of zein‐based fibrous scaffolds for biomedical applications is achieved by a wide variety of techniques, including electrospinning, wet spinning, freeze drying, and additive manufacturing. This article overviews current advancements in manufacturing techniques for zein‐based fibrous scaffolds. In addition, it summarizes the most recent biomedical applications and research activities utilizing zein‐based fibrous scaffolds. Overall, zein is proposed as a potential biomaterial for the production of fibrous scaffolds that stimulate cell adhesion and proliferation in a number of exciting biomedical applications due to its biodegradability, biocompatibility, and other unique features related to its structure.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0RA06556K
Abstract: Directional growth induced by dopamine-functionalized CNF-based nanocomposite ink printing.
Publisher: Wiley
Date: 2007
DOI: 10.1002/APP.25034
Publisher: Elsevier
Date: 2004
Publisher: Elsevier BV
Date: 06-2020
Publisher: Wiley
Date: 08-2003
Publisher: Elsevier BV
Date: 04-2020
Publisher: Elsevier BV
Date: 11-2021
Publisher: MDPI AG
Date: 30-01-2023
DOI: 10.3390/NANO13030566
Abstract: ZnO nanoparticles (NPs) show remarkable efficiency in removing various contaminants from aqueous systems. Doping ZnO NPs with a second metal element can dramatically change the physicochemical properties of the pristine nanoparticles. However, there have been limited reports on the absorption of doped ZnO NPs, especially comparing the performance of ZnO NPs with different doping elements. Herein, ZnO NPs were doped with three transitional metals (Co, Fe, and Mn) at a nominal 2 wt.%. The particle surface had a higher dopant concentration than the interior for all NPs, implying the migration of the dopants to the surface. Because doping atoms inhibited grain growth, the doped ZnO NPs had a small particle size and a large surface area. The adsorption performance followed the order of Fe-doped undoped Mn-doped Co-doped ZnO. Co-doped ZnO had an increased surface area and less tendency to agglomerate in an aqueous solution, showing the best adsorption performance. The adsorption of Congo red (CR) on Co-doped ZnO followed the pseudo-second-order model and the Langmuir isotherm. The adsorption process was spontaneous through monolayer chemisorption, and the maximum adsorption capacity was 230 mg/g. Finally, the Co-doped ZnO was successfully incorporated into an alginate membrane by electrospinning. The membrane demonstrated excellent adsorption performance and had great potential as an innovative and low-cost adsorbent (inexpensive raw materials and simple processing) for wastewater purification.
Publisher: American Chemical Society (ACS)
Date: 06-03-2021
Publisher: Wiley
Date: 15-12-2021
DOI: 10.1002/JBM.B.34987
Abstract: Gallium and its alloys, such as eutectic gallium indium alloy (EGaIn), a form of liquid metal, have recently attracted the attention of researchers due to their low toxicity and electrical and thermal conductivity for biomedical application. However, further research is required to harness EGaIn‐composites advantages and address their application as a biomedical scaffold. In this research, EGaIn‐polylactic acid olycaprolactone composites with and without a second conductive filler, MXene, were prepared and characterized. The addition of MXene, into the EGaIn‐composite, can improve the composite's electrochemical properties by connecting the liquid metal droplets resulting in electrically conductive continuous pathways within the polymeric matrix. The results showed that the composite with 50% EGaIn and 4% MXene, displayed optimal electrochemical properties and enhanced mechanical and radiopacity properties. Furthermore, the composite showed good biocompatibility, examined through interactions with fibroblast cells, and antibacterial properties against methicillin‐resistant Staphylococcus aureus . Therefore, the liquid metal (EGaIn) polymer composite with MXene provides a first proof‐of‐concept engineering scaffold strategy with low toxicity, functional electrochemical properties, and promising antimicrobial properties.
Publisher: Wiley
Date: 2005
DOI: 10.1002/APP.20874
Publisher: Walter de Gruyter GmbH
Date: 12-2010
DOI: 10.1515/EPOLY.2010.10.1.336
Abstract: Preparation and characterization of novel composites, consisting of polypropylene (PP) fibres in a random poly(propylene-co-ethylene) (PPE) matrix, were investigated. These composites possess unique properties, due to chemical compatibility of the two polymers allowing creation of strong physico-chemical interactions and strong interfacial bonds. The difference between the melting temperatures of PP fibre and PPE was exploited in order to establish processing conditions for the composites. Suitable conditions were chosen so that the matrix was a liquid, to ensure good wetting and impregnation of the fibres, though the temperature must not be high enough to melt the fibres. The morphology of the composites was investigated using optical and scanning electron microscopy. Optical microscope images showed that transcrystallization of the matrix was observed on PP fibre surfaces. SEM photographs displayed a thin layer of matrix on the reinforcement, attributed to good impregnation and wetting of the fibres. Adhesion between PPE matrix and PP fibres was characterized using a microbond test inspired by a fibre pull-out technique. The results showed that adhesion was appreciably increased when PP fibres were used instead of glass fibres in the matrix. Nevertheless, thermal processing conditions of the composites caused reduction in mechanical behaviour of the reinforcement.
Publisher: Elsevier BV
Date: 12-2019
DOI: 10.1016/J.JMBBM.2019.103412
Abstract: The incidence of total hip arthroplasty (THA) has been evidently growing over the last few decades. Surface modification, such as polymer grafting onto implant surfaces using poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC), has been gaining attention due to its excellent biocompatibility and high lubricity behaviour resulting in reducing surgical recurrence number and increasing implant lifetime. Investigating thermal stability and mechanical properties of the grafted polymer is, therefore, extremely important as these properties define the failure mechanism of implants. This study focuses on optimising monomer concentration to achieve the best physical, thermal and mechanical properties of the grafted additively manufactured titanium (Ti6Al4V) implants. Three different concentration of monomers, 0.4 M, 0.6 M and 0.8 M, were investigated, and grafted implants were characterised. The results from thermal analysis confirmed that the PMPC polymer is thermally stable for implant applications regardless of the monomer concentrations. A significant reduction in Young's modulus of polymer grafted s les (33.2-42.9%), in comparison with untreated Ti6Al4V s les and consequent improvement of wear resistance and elasticity behaviour, proved the potentiality of polymer films for implant applications. In summary, polymer grafted implant prepared with 0.6 M monomer concentration showed the optimal thermal, physical and wear resistance properties.
Publisher: Springer Science and Business Media LLC
Date: 12-2014
DOI: 10.1186/S40038-014-0004-0
Abstract: Fire-fighters’ personal protective clothing is the only source of protection for fire-fighters during fire-fighting. The protective clothing should provide adequate protection as well as should be comfortable to wear. The protection and comfort requirements are always the contradicting fact in several protective clothing including fire-fighters’. Appropriate material selection, clothing design and final evaluation of the results play a critical role in predicting the clothing performance and comfort. Several researches have been done on the performance and comfort improvement of fire-fighter’s protective clothing. However, detailed review related to these parameters is not being reported in recent years. In this perspective review, we report the recent trends in the performance and comfort properties of the fire-fighters protective clothing. The clothing design and different materials used to achieve a balance between performance and comfort is illustrated. Various test standards related to the performance and comfort is also being discussed. In addition, the future scopes and challenges while designing tomorrows advanced protective clothing are cited. This would provide a guideline in terms of comfort and performance while developing and designing the fire-fighter protective clothing for different climatic conditions.
Publisher: ACM
Date: 13-09-2014
Publisher: Elsevier BV
Date: 02-2021
Publisher: American Chemical Society (ACS)
Date: 13-10-2020
Publisher: American Chemical Society (ACS)
Date: 11-09-2020
Publisher: Elsevier BV
Date: 04-2005
Publisher: Elsevier
Date: 2017
Publisher: Springer Science and Business Media LLC
Date: 14-10-2023
Publisher: Elsevier BV
Date: 08-2019
DOI: 10.1016/J.MSEC.2019.04.017
Abstract: Despite the tremendous acceptance of additively manufactured (AM) Titanium alloys (Ti6Al4V) in the field of biomedical engineering, the high surface roughness due to partially-melted particles (fabricated in selective laser melting (SLM) process), limits their uses as hip implants. The objective of this study, therefore, is to modify the SLM fabricated Ti6Al4V implant interfaces with 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer, in the hope of enhancing surface properties and preventing the attachment of the cell simultaneously without affecting the mechanical properties significantly. Three different monomer concentrations were examined to determine the influence of monomer concentrations on polymerisation rate, chain length, and surface properties of the implants. S les grafted with 0.6 M monomer concentration showed more uniform surface and less surface roughness in comparison with other s les and untreated Ti6Al4V surfaces. 0.6 M monomer concentration was found to be the best option for grafting PMPC to the hip implant interfaces because of its improved surface morphology, surface roughness, polymerisation rate, penetration depth and hardness results. Moreover, cell study on optimal surfaces revealed that PMPC grafted surfaces prevent the implant interfaces from uncontrollable cell attachment which is of utmost importance in smoothing the motion of the hip implant under cyclic loading. Overall, the PMPC grafting demonstrated the potentiality of its application on SLM Ti6Al4V substrate for improved hip arthroplasty performance.
Publisher: Informa UK Limited
Date: 23-01-2015
Publisher: American Chemical Society (ACS)
Date: 27-05-2020
Abstract: In this study, silk filaments are coated with different concentrations (5, 7.5, and 10% w/w) of carbon nanofibers (CNFs) dispersed in poly-ε-caprolactone. The nanocomposite-coated silk filaments are subjected to knitting, braiding, and twisting. The tubular structures are covered with a silk fibroin olyvinyl film for the nerve conduit application. Physical characterization of the developed nerve conduits demonstrates suitable mechanical properties comparable to native nerve tissue. Cell proliferation is confirmed through in vitro cell culture studies using Neuro 2a and rat primary cortical neural progenitor cells, which show that the proliferation happens along the interconnected macrochannels of the internal structure of the nerve conduit. The knitted structure presents better biological properties than the nerve conduits with other internal structures. The in vivo sciatic nerve implantation is performed in a rabbit model using the best conduit, i.e., 10% CNF-based nanocomposite-coated silk with a knitted inner structure without any biomolecules or tube filling gels. Regeneration of a 2 cm gap excised sciatic nerve is investigated by immunohistochemistry and histology of implanted nerve conduits removed after 30 days. Results suggest that the CNF-based conducting nanocomposite coating in this well-defined architecture of the conduit helps in signal transmission and neural growth during the regeneration of the transected nerve.
Publisher: Informa UK Limited
Date: 29-01-2022
Publisher: Textile Bioengineering and Informatics Society
Date: 06-2014
DOI: 10.3993/JFBI12201412
Publisher: American Chemical Society (ACS)
Date: 12-07-2023
Publisher: Springer Science and Business Media LLC
Date: 14-05-2019
Publisher: Wiley
Date: 10-02-2022
Abstract: The development of cooling textiles has a significant impact on energy saving and cost‐effectiveness in the context of global warming. Engineering textiles with cooling performance while maintaining their intrinsic traits, for ex le, lightweight, washable, comfort, and durability, is a great challenge in developing personal cooling garments. Here, the synthesis of nanodiamond olydopamine/wool (ND‐PDA‐wool) nanocomposites through a facile dip‐coating approach is demonstrated. Different types of ND including detonation ND (DND), carboxylated ND (ND‐COOH) and hydroxylated ND (ND‐OH), are used, and dopamine templating is applied to achieve strong adhesion and bonding between fiber and ND. The morphology, structure, and properties of the as‐coated fabrics are characterized, and the cooling performance together with comfort are measured. Due to the excellent thermal conductivity of ND, the temperature difference between the coated fabrics and uncoated ones is around 2.4–3.9 °C within a short time span of 30 min. The coated ND‐PDA‐Wool fabrics demonstrated enhanced thermal stability and improved mechanical properties with excellent durability, and the water absorbency is greatly enhanced with well‐maintained air permeability. ND‐PDA‐wool composite fabrics offer a strategy to develop durable, lightweight, washable, and comfortable cooling textiles with immense potential in energy saving and reducing space cooling costs.
Publisher: Elsevier BV
Date: 03-2021
Publisher: Elsevier BV
Date: 12-2021
Publisher: American Chemical Society (ACS)
Date: 07-11-2019
Abstract: Polypropylene (PP) surgical mesh has attracted vast attention due to its chemical inertness and excellent mechanical properties. However, improvement is necessary to enhance its biocompatibility and to prevent unwanted tissue adhesion. This study addresses these issues through surface modification of plasma-activated PP mesh with a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. Reaction time and monomer concentration have been optimized to achieve the optimal biocompatibility with reduction in protein adsorption. Attenuated total reflection-Fourier transform infrared spectra confirmed the grafting of the MPC polymer (PMPC) to the plasma-activated polypropylene (PPP) mesh. Scanning electron microscopy images and energy-dispersive X-ray (EDX) line spectra exhibited morphological changes and specifically PMPC grafting to the surface of PPP mesh, due to the presence of a significant amount of phosphorus (P) on the grafted PPP mesh. PMPC-grafted polypropylene (PPP-PMPC) showed a significant reduction in contact angle as well as the amount of adsorbed bovine serum albumin (BSA) protein in comparison with pristine PP mesh. The highest reduction in protein adsorption and the lowest contact angle were achieved at the monomer concentration of 0.3 M and the reaction time of 90 min. A longer reaction time and higher monomer concentration resulted in clogging within the mesh pores. MTT assay results (∼90% cell viability) confirmed the nontoxicity of the PMPC-grafted mesh, while optical microscopic and SEM images showed increased resistance of cell attachment to the surface of PMPC-grafted mesh. The results show that PPP-PMPC can be a promising biomaterial to address the current issues in biocompatibility and reduction in adhesion after surgery.
Publisher: Wiley
Date: 12-01-2021
Publisher: American Chemical Society (ACS)
Date: 19-06-2019
DOI: 10.1021/ACSCHEMNEURO.9B00203
Abstract: Peripheral nerve injuries (PNIs) are the most common injury types to affect the nervous system. Restoration of nerve function after PNI is a challenging medical issue. Extended gaps in transected peripheral nerves are only repaired using autologous nerve grafting. This technique, however, in which nerve tissue is harvested from a donor site and grafted onto a recipient site in the same body, has many limitations and disadvantages. Recent studies have revealed artificial nerve conduits as a promising alternative technique to substitute autologous nerves. This Review summarizes different types of artificial nerve grafts used to repair peripheral nerve injuries. These include synthetic and natural polymers with biological factors. Then, desirable properties of nerve guides are discussed based on their functionality and effectiveness. In the final part of this Review, fabrication methods and commercially available nerve guides are described.
Publisher: SAGE Publications
Date: 13-10-2014
Abstract: The use of appropriate protective clothing systems in high-risk environments is absolutely essential. Such protective clothing may not provide the desired wearer comfort due to the complexities associated with the system. These constraints are largely due to the multiple layers involved in the protective ensemble. Firefighters’ protective clothing systems, in particular, have limited or no water vapor permeability. This prevents evaporative heat loss and leads to thermal strain and sweat accumulation. This accumulated sweat on the skin and on the internal layer close to the body causes considerable discomfort to the user due to the sensation of wetness. Extensive research has been done to improve the comfort properties of such protective clothing. This research adds yet another dimension where a new inner-layer construction has been developed with high liquid and vapor-absorption capacity that could assist in keeping the moisture and vapor away from the skin and, in addition, retain a dry microclimate close to the skin. The developed materials were tested for their biophysical properties that included tests such as thermal and water vapor resistance, air permeability and moisture management properties. Experimental results in this study indicated that super-absorbent materials, when incorporated into a woven textile material, showed enhanced wearer comfort. It was observed that these super-absorbent materials have the capability to quickly wick the moisture away from the body and, in doing so, have the tendency to keep the skin dry.
Publisher: Elsevier BV
Date: 02-2020
DOI: 10.1016/J.NANO.2019.102131
Abstract: In this work, the effects of carbon nanofiber (CNF) dispersed poly-ε-caprolactone (PCL) nanocomposite coatings and biomolecules functionalization on silk fibroin based conducting braided nerve conduits were studied for enhancing Neuro 2a cellular activities. A unique combination of biomolecules (UCM) and varying concentrations of CNF (5, 7.5, 10% w/w) were dispersed in 10% (w/v) PCL solution for coating on degummed silk threads. The coated silk threads were braided to develop the scaffold structure. As the concentration of CNF increased in the coating, the electrical impedance decreased up to 400 Ω indicating better conductivity. The tensile and dynamic mechanical property analysis showed better mechanical properties in CNF coated s les. In vitro cytocompatibility analysis proved the non-toxicity of the developed braided conduits. Cell attachment, growth and proliferation were significantly enhanced on the biomolecule functionalized nanocomposite coated silk braided structure, exhibiting their potential for peripheral nerve regeneration and recovery.
Publisher: Elsevier BV
Date: 02-2021
Publisher: American Chemical Society (ACS)
Date: 21-06-2022
Publisher: Elsevier BV
Date: 2007
DOI: 10.1016/J.BIOMATERIALS.2006.08.026
Abstract: The advent of injectable polymer technologies has increased the prospect of developing novel, minimally invasive arthroscopic techniques to treat a wide variety of ailments. In this study, we have synthesised and evaluated a novel polyurethane-based injectable, in situ curable, polymer platform to determine its potential uses as a tissue engineered implant. Films of the polymers were prepared by reacting two pentaerythritol-based prepolymers, and characterised for mechanical and surface properties, and cytocompatibility. This polymer platform displayed mechanical strength and elasticity superior to many injectable bone cements and grafts. Cytotoxicity tests using primary human osteoblasts, revealed positive cell viability and increased proliferation over a period of 7 days in culture. This favourable cell environment was attributed to the hydrophilic nature of the films, as assessed by dynamic contact angle (DCA) analysis of the s le surfaces. The incorporation of beta-TCP was shown to improve mechanical properties, surface wettability, and cell viability and proliferation, compared to the other s le types. SEM/EDX analysis of these surfaces also revealed physicochemical surface heterogeneity in the presence of beta-TCP. Based on preliminary mechanical analysis and cytotoxicity results, these injectable polymers may have a number or potential orthopaedic applications ranging from bone glues to scaffolds for bone regeneration.
Publisher: MDPI AG
Date: 20-06-2022
DOI: 10.3390/S22124643
Abstract: The work describes the design, manufacturing, and user interface of a thin-film gas transducer platform that is able to provide real-time detection of toxic vapor. This proof-of-concept system has applications in the field of real-time detection of hazardous gaseous agents that are harmful to the person exposed to the environment. The small-size gas sensor allows for integration with an unmanned aerial vehicle, thus combining high-level mobility with the ability for the real-time detection of hazardous/toxic chemicals or use as a standalone system in industries that deal with harmful gaseous substances. The sensor was designed based on the ability of thin-film metal oxide sensors to detect chlorine gas in real time. Specifically, a concentration of 10 ppm of Cl2 was tested.
Publisher: Wiley
Date: 28-09-2004
DOI: 10.1002/PI.1569
Publisher: Elsevier BV
Date: 11-2018
DOI: 10.1016/J.JMBBM.2018.07.031
Abstract: A significant number of hip replacements (HR) fail permanently despite the success of the medical procedure, due to wear and progressive loss of osseointegration of implants. An ideal model should consist of materials with a high resistance to wear and with good biocompatibility. This study aims to develop a new method of grafting the surface of selective laser melted (SLM) titanium alloy (Ti-6Al-4V) with poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC), to improve the surface properties and biocompatibility of the implant. PMPC was grafted onto the SLM fabricated Ti-6Al-4V, applying the following three techniques ultraviolet (UV) irradiation, thermal heating both under normal atmosphere and UV irradiation under N
Publisher: Wiley
Date: 09-08-2023
DOI: 10.1002/JBM.A.37595
Abstract: At present, peripheral nerve injuries (PNIs) are one of the leading causes of substantial impairment around the globe. Complete recovery of nerve function after an injury is challenging. Currently, autologous nerve grafts are being used as a treatment however, this has several downsides, for ex le, donor site morbidity, shortage of donor sites, loss of sensation, inflammation, and neuroma development. The most promising alternative is the development of a nerve guide conduit (NGC) to direct the restoration and renewal of neuronal axons from the proximal to the distal end to facilitate nerve regeneration and maximize sensory and functional recovery. Alternatively, the response of nerve cells to electrical stimulation (ES) has a substantial regenerative effect. The incorporation of electrically conductive biomaterials in the fabrication of smart NGCs facilitates the function of ES throughout the active proliferation state. This article overviews the potency of the various categories of electroactive smart biomaterials, including conductive and piezoelectric nanomaterials, piezoelectric polymers, and organic conductive polymers that researchers have employed latterly to fabricate smart NGCs and their potentiality in future clinical application. It also summarizes a comprehensive analysis of the recent research and advancements in the application of ES in the field of NGC.
Publisher: Elsevier BV
Date: 06-2021
Publisher: Wiley
Date: 03-06-2021
DOI: 10.1002/JBM.A.37237
Abstract: Polypropylene (PP) mesh is most commonly used for the treatment of hernia and pelvic floor construction. However, some of the patients have a few complications after surgery due to the rejection or infection of the implanted meshes. The poor biocompatibility of PP mesh, low wettability results in poor cell attachment roliferation and restricts the loading of antibacterial agent, leading to a slow healing process and high risk of infection after surgery. Here in this study, a new technique has been employed to develop a novel antimicrobial and biocompatible PP mesh modified with bioactive chitosan and functionalized nanodiamond (FND) for infection inhibition and acceleration of the healing process. An oxygen plasma treatment PP mesh was used then chitosan was strongly attached to the surface of the PP fibers. Subsequently, FND as an antibacterial agent was loaded into the chitosan modified PP fiber to provide desired antibacterial functions. The meshes were characterised with XRD, FTIR, SEM, EDX, water contact angle, confocal, and optical microscopy. The modified PP mesh with chitosan and FND showed a significant increase in its hydrophilicity and L929 fibroblast cell attachment. Furthermore, the modified mesh exhibited great antibacterial efficiency against Escherichia coli . Therefore, the newly developed technique to modify PP mesh could be a promising technique to generate a biocompatible PP mesh to accelerate the healing process and reduce the risk of infection after surgery.
Publisher: American Chemical Society (ACS)
Date: 09-06-2021
Publisher: Springer Science and Business Media LLC
Date: 09-2020
DOI: 10.1557/ADV.2020.268
Publisher: Wiley
Date: 12-11-2015
DOI: 10.1002/APP.43073
Publisher: Textile Bioengineering and Informatics Society
Date: 06-2017
DOI: 10.3993/JFBIM00257
Publisher: Elsevier BV
Date: 07-2019
DOI: 10.1016/J.MSEC.2019.02.110
Abstract: We describe preparation, characterization and cytocompatibility of nanodiamond (ND) dispersed in poly (ε-caprolactone) (PCL) based nanofibrous scaffold. The results show that this unique scaffold potentially provides essential properties for wound healing by enhancing proliferation of epithelial cells, in addition to restricting the microbial activities. Electrospinning technique was used to fabricate and develop PCL-NDs nanocomposite scaffold. The developed nanocomposites were characterized for morphology, thermal, surface and biological properties. The incorporation of ND into the PCL matrix resulted in better moisture management and higher thermal stability. Transmission electron microscopy images and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy showed existence of ND particles on the surface of the nanofibers. The aggregation of ND particles increased with the increase in their concentration in nanofiber. The developed scaffolds showed no cytotoxicity and, due to improved hydrophilicity, better cellular activities with Chinese hamster ovarian (CHO) cells, 43%, 38% and 22% more cell proliferation for PCL-5% ND for 1, 3- and 7-days incubations in compare with PCL. Furthermore, Staphylococcus aureus (S. aureus) showed significantly less affinity to the scaffold surface with the increase in ND concentration, ~56% less for PCL-5% ND in compare with PCL, indicating that such ND dispersed nanofibrous scaffold maybe asuitable choice for complex wound management.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3PY00395G
Abstract: Molecular descriptors and machine learning are useful tools for extracting structure–property relationships from large, complex polymer data, and accelerating the design of novel polymers with tailored functionalities.
Publisher: Wiley
Date: 05-01-2006
Publisher: Wiley
Date: 16-05-2023
Abstract: Polypropylene (PP) based hernia mesh often shows multiple post‐surgery complications due to lack of biocompatibility, poor cell attachment, and unwanted tissue adhesion. These limitations can be addressed by material designing and surface modification of a mesh with side‐specific properties such as the visceral side (facing intestine) with low protein and cell attachment and the parietal side (facing incision) with improved cell attachment properties for normal healing. However, the development of dual‐sided mesh is very challenging because of its porous structure. Herein, a dual‐sided biocompatible mesh with protein anti‐adsorption and cell attachment properties on two different sides is developed by grafting highly hydrophilic 2‐methcryloyloxyethyl phosphorylcholine polymer (PMPC) on the plasma‐activated visceral side, while the parietal side is coated with bioactive chitosan and functionalized nanodiamond (Chi/FND) using a temporary polyvinyl alcohol (PVA) mold. The PMPC‐grafted side demonstrated excellent resistance to protein adsorption (96% reduction compared to PP) and cell attachment. However, the bioactive coating on the parietal side has significantly improved cell attachment and proliferation properties. In addition, both sides confirmed the presence of the respective biomaterials after an accelerated degradation study for 28 days. Hence, the newly developed dual‐sided mesh by semi‐solid polymer mold (SSPM) method is a promising candidate to address the long‐existing multiple issues of hernia mesh.
Publisher: Elsevier
Date: 2017
Publisher: American Chemical Society (ACS)
Date: 06-05-2019
Publisher: Elsevier BV
Date: 07-2022
Publisher: SAGE Publications
Date: 07-08-2017
Abstract: This study evaluated the deterioration in thermo-mechanical and performance properties of the polyaramid and polybenzidimazole fabric used in firefighters’ protective clothing after exposure to ultraviolet irradiation, and the effect of weathering. The performance of firefighters’ protective clothing plays an important role in protection against heat and physical threats to firefighters. However, frequent exposure to heat and ultraviolet irradiation can deteriorate performance. Test results demonstrated a 79% drop in the residual strength of polybenzidimazole/Kevlar® fabric and a 51% drop in the residual strength of polyaramid (Nomex® IIIA). The results confirmed that heat accelerates the degradation of PBI, resulting in lower performance, an important consideration for firefighters’ protective clothing. In this study, a new ‘UVPro-Tex’ sensor was developed, with the capability to record the amount of ultraviolet irradiation absorbed by the fabric. When the amount of the absorbed ultraviolet irradiation reaches a critical value, the sensor warns the wearer of the end-of-life of the garment.
Publisher: Elsevier BV
Date: 2023
Publisher: Elsevier BV
Date: 10-2008
DOI: 10.1016/J.BIOMATERIALS.2008.06.021
Abstract: Biodegradable polyurethanes offer advantages in the design of injectable or preformed scaffolds for tissue engineering and other medical implant applications. We have developed two-part injectable prepolymer systems (prepolymer A and B) consisting of lactic acid and glycolic acid based polyester star polyols, pentaerythritol (PE) and ethyl lysine diisocyanate (ELDI). This study reports on the formulation and properties of a series of cross linked polyurethanes specifically developed for orthopaedic applications. Prepolymer A was based on PE and ELDI. Polyester polyols (prepolymer B) were based on PE and dl-lactic acid (PEDLLA) or PE and glycolic acid (PEGA) with molecular weights 456 and 453, respectively. Several cross linked porous and non-porous polyurethanes were prepared by mixing and curing prepolymers A and B and their mechanical and thermal properties, in vitro (PBS/37 degrees C H 7.4) and in vivo (sheep bi-lateral) degradation evaluated. The effect of incorporating beta-tricalcium phosphate (beta-TCP, 5 microns, 10 wt.%) was also investigated. The cured polymers exhibited high compressive strength (100-190 MPa) and modulus (1600-2300 MPa). beta-TCP improved mechanical properties in PEDLLA based polyurethanes and retarded the onset of in vitro and in vivo degradation. Sheep study results demonstrated that the polymers in both injectable and precured forms did not cause any surgical difficulties or any adverse tissue response. Evidence of new bone growth and the gradual degradation of the polymers were observed with increased implant time up to 6 months.
Publisher: Springer Science and Business Media LLC
Date: 06-2016
Publisher: Wiley
Date: 02-01-2020
DOI: 10.1002/JBM.A.36868
Abstract: The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.
Publisher: Springer Science and Business Media LLC
Date: 02-2017
Location: Iran (Islamic Republic of)
Location: Australia
Start Date: 2021
End Date: 2026
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2021
End Date: 07-2026
Amount: $5,000,000.00
Funder: Australian Research Council
View Funded Activity