ORCID Profile
0000-0002-6956-4686
Current Organisation
Karolinska Institutet
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Civil Engineering | Construction Materials | Urban and Regional Planning not elsewhere classified | Civil Geotechnical Engineering | Infrastructure Engineering and Asset Management | Structural Engineering |
Environmentally Sustainable Manufacturing not elsewhere classified | Road Freight | Road Infrastructure and Networks | Management of Greenhouse Gas Emissions from Construction Activities | Environmentally Sustainable Construction not elsewhere classified
Publisher: Elsevier BV
Date: 11-2022
Publisher: Informa UK Limited
Date: 20-04-2022
Publisher: MDPI AG
Date: 09-08-2022
DOI: 10.3390/MOLECULES27165068
Abstract: Bitumen is a major construction material that can emit harmful fumes when heated. These fumes pose health risks to workers and communities near construction projects or asphalt mixing plants. The chemical complexity of bitumen fumes and the increasing use of additives add to the difficulty of analytically quantifying the harmful chemicals emitted using a single technique. Research on bitumen emissions consists of numerous s le preparation and analytical methods. There are a range of considerations to be made when deciding on an appropriate s le preparation method and instrumental configuration to optimise the analysis of specific organic contaminants in emissions. Researchers investigating emissions from bituminous materials may need to consider a range of analytical techniques to quantify harmful chemicals and assess the efficacy of new additives. This review summarises the primary methodologies for s le preparation and analytical techniques used in bitumen research and discusses future challenges and solutions.
Publisher: MDPI AG
Date: 25-03-2020
DOI: 10.3390/MA13071495
Abstract: Waste management has become an issue of increasing concern worldwide. These products are filling landfills and reducing the amount of livable space. Leachate produced from landfills contaminates the surrounding environment. The conventional incineration process releases toxic airborne fumes into the atmosphere. Researchers are working continuously to explore sustainable ways to manage and recycle waste materials. Recycling and reuse are the most efficient methods in waste management. The pavement industry is one promising sector, as different sorts of waste are being recycled into asphalt concrete and bitumen. This paper provides an overview of some promising waste products like high-density polyethylene, marble quarry waste, building demolition waste, ground tire rubber, cooking oil, palm oil fuel ash, coconut, sisal, cellulose and polyester fiber, starch, plastic bottles, waste glass, waste brick, waste ceramic, waste fly ash, and cigarette butts, and their use in asphalt concrete and bitumen. Many experts have investigated these waste materials and tried to find ways to use this waste for asphalt concrete and bitumen. In this paper, the outcomes from some significant research have been analyzed, and the scope for further investigation is discussed.
Publisher: Elsevier BV
Date: 11-2023
Publisher: Springer Science and Business Media LLC
Date: 16-08-2021
Publisher: Springer Science and Business Media LLC
Date: 08-06-2021
Publisher: Elsevier BV
Date: 03-2023
Publisher: Elsevier BV
Date: 06-2022
DOI: 10.1016/J.JENVMAN.2022.114926
Abstract: Expansive clays are found in many countries worldwide, and they exhibit inherent volume change during the seasonal moisture variation causing cracks, heaves, and damages to the overlying pavements. Chemical stabilisation is one of the most used approaches to treat the expansive clay subgrades. Cement, Lime and Fly ash are the most commonly used stabilisers, in which fly is cheaper and a by-product obtained from the coal power plant. This paper reviews fly ash stabilisation on various clay types, including low plasticity clays, high plasticity clays, silty clays, organic clays, and peats. The review begins with the properties of fly ash, followed by the characteristics of fly ash stabilised subgrades. The micro-level mechanism, physical, mechanical, and hydraulic characteristics of stabilised pavements are presented graphically for the Class C, and F fly ashes. The micro-level studies reveal that the pozzolanic reaction is stronger than the cation exchange during the fly ash stabilisation. The unconfined compressive strength (UCS), California bearing ratio (CBR) and resilient modulus (M
Publisher: Informa UK Limited
Date: 22-05-2020
Publisher: Springer Science and Business Media LLC
Date: 15-11-2023
DOI: 10.1038/S41375-022-01746-3
Abstract: Infants with KMT2A -rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes have remained static in recent decades despite treatment intensification and novel therapies are urgently required. KMT2A -rearranged infant ALL cells are characterized by an abundance of promoter hypermethylation and exhibit high BCL-2 expression, highlighting potential for therapeutic targeting. Here, we show that hypomethylating agents exhibit in vitro additivity when combined with most conventional chemotherapeutic agents. However, in a subset of s les an antagonistic effect was seen between several agents. This was most evident when hypomethylating agents were combined with methotrexate, with upregulation of ATP-binding cassette transporters identified as a potential mechanism. Single agent treatment with azacitidine and decitabine significantly prolonged in vivo survival in KMT2A -rearranged infant ALL xenografts. Treatment of KMT2A -rearranged infant ALL cell lines with azacitidine and decitabine led to differential genome-wide DNA methylation, changes in gene expression and thermal proteome profiling revealed the target protein-binding landscape of these agents. The selective BCL-2 inhibitor, venetoclax, exhibited in vitro additivity in combination with hypomethylating or conventional chemotherapeutic agents. The addition of venetoclax to azacitidine resulted in a significant in vivo survival advantage indicating the therapeutic potential of this combination to improve outcome for infants with KMT2A -rearranged ALL.
Publisher: Elsevier BV
Date: 12-2022
Publisher: Elsevier BV
Date: 05-2022
Publisher: Elsevier BV
Date: 12-2016
Abstract: Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent inhibitors of MTH1 were demonstrated to be non-toxic to cancer cells, challenging the utility of MTH1 inhibition as a target for cancer treatment. Human cancer cell lines were exposed in vitro to MTH1 inhibitors or depleted of MTH1 by siRNA or shRNA. 8-oxodG was measured by immunostaining and modified comet assay. Thermal Proteome profiling, proteomics, cellular thermal shift assays, kinase and CEREP panel were used for target engagement, mode of action and selectivity investigations of MTH1 inhibitors. Effect of MTH1 inhibition on tumour growth was explored in BRAF V600E-mutated malignant melanoma patient derived xenograft and human colon cancer SW480 and HCT116 xenograft models. Here, we demonstrate that recently described MTH1 inhibitors, which fail to kill cancer cells, also fail to introduce the toxic oxidized nucleotides into DNA. We also describe a new MTH1 inhibitor TH1579, (Karonudib), an analogue of TH588, which is a potent, selective MTH1 inhibitor with good oral availability and demonstrates excellent pharmacokinetic and anti-cancer properties in vivo. We demonstrate that in order to kill cancer cells MTH1 inhibitors must also introduce oxidized nucleotides into DNA. Furthermore, we describe TH1579 as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept.
Publisher: Informa UK Limited
Date: 16-02-2021
Publisher: Elsevier BV
Date: 07-2022
Publisher: MDPI AG
Date: 30-11-2022
DOI: 10.3390/BUILDINGS12122098
Abstract: The study conducts a comprehensive life cycle assessment (LCA) of precast sandwich panels by integrating operational and embodied phases detailing thermal efficiency and environmental impacts. The analytical regression model is developed for climatic ersity and design variables using the energy rating tool FirstRate5 to compare with a conventional brick veneer construction. LCA is performed on the building information modeling (BIM) platform to connect operational energy and express the relative embodied impacts of insulation constituents, compressive strength, reinforcement, and mix design. Monte Carlo simulation shows significant advantages of concrete sandwich panels in reducing operational H/C loads over building service life. LCA reveals a 100 mm thick external precast concrete wall with 50% fly ash reduces CO2 emission and energy demand by 54.7% and 75.9% consecutively against the benchmark. Moreover, it comprises 84.31% of the total building mass, accountable for only 53.27% of total CO2 emission and 27.25% of energy demand, which is comparatively lower than other materials. In the case of selecting lining insulation, a broader benefit is identified for extruded polystyrene (XPS) and expanded polystyrene (EPS) boards due to their relative weight, thickness, and environmental impacts. Representative equations of energy efficiency and impact assessment will assist in adopting sandwich panels for new construction and refurbishment with relative dimensions.
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 12-2022
DOI: 10.1016/J.JENVMAN.2022.116289
Abstract: This study conducts a comprehensive life cycle assessment (LCA) on converting waste vehicle tyres into recycled crumb rubber (CR) granules as an alternative polymer for enhancing asphalt properties. The LCA study has been performed on acquired industrial primary data by incorporating CR at different proportions of binder in one ton (1-ton) of asphalt mix following the wet method. The uncertainty analysis of design variables identified a relatively strong positive relation of emissions with the equipment energy consumption (r = 0.98). Monte Carlo simulations evaluate the potential renewable sources (solar, hydro, and wind) in sequence over fossil fuels for the possible transition in the Australian grid by 2030 and 2050, as per the Paris Agreement. 71.91% reduction of CO
Publisher: Elsevier BV
Date: 09-2023
Publisher: American Society of Civil Engineers (ASCE)
Date: 11-2022
Publisher: MDPI AG
Date: 13-10-2023
DOI: 10.3390/SU152014861
Publisher: MDPI AG
Date: 17-12-2021
DOI: 10.3390/MA14247839
Abstract: Accurate characterisation and appropriate binder selection are essential to increase the load-induced cracking resistance of asphalt mixtures at an intermediate temperature. Hence, the primary goal of this study was to correlate the cracking resistance exerted by the binder with the cracking performance of asphalt mixtures. The laboratory-based experimental plan covered various types of laboratory tests specified by various agencies and road authorities to study the correlation of a neat bitumen and five polymer-modified binders with their corresponding asphalt mixtures. The fatigue life of the binders was assessed through a Linear Amplitude Sweep (LAS) test and statistically correlated with various load-induced cracking parameters from the indirect tensile test, semi-circular bending (SCB) test, and four points bending beam test (FPBB) of asphalt mixtures at 25 °C. Binders and mixes were further grouped depending on their polymeric family (i.e., modified with a particular type of polymer) to validate their statistical correlation. The indicator that mostly correlated the binder properties with the asphalt mixture properties is the secant modulus from the SCB test. Fatigue parameters obtained through LAS better explain the asphalt fatigue performance obtained through FPBB specifically, asphalt tests at high strain levels (e.g., 400 micro strain) better correlate to the LAS fatigue parameter (Nf).
Publisher: Elsevier BV
Date: 12-2020
Publisher: MDPI AG
Date: 06-02-2020
DOI: 10.3390/MA13030734
Abstract: Littering waste is among the top environmental issues in the world, and the management of the waste has turned into a challenge in almost every city. It has been reported that 75% of smokers dispose of their cigarette butts (CBs) on the ground, even in public places. Researchers have discovered that CBs make up more than one-third of the total littered waste on the planet. Cigarette butts predominantly consist of a cellulose acetate fiber (plastic)-based filter wrapped in paper. Waste CBs contain burnt tobacco and tar, along with many other toxic chemicals. They take years to biodegrade depending on the environmental conditions, and toxic chemicals leach out and contaminate the environment. As part of an ongoing project, this paper presents a novel and sustainable technique to recycle cigarette butts in bitumen for the construction of flexible pavements. In this research, CBs have been pre-processed and mixed with bitumen classes C320, C170, and PMB A10E as a fiber modifier. Comprehensive laboratory investigations, including a penetration test, softening point test, and viscosity test, have been performed along with a binder drain off test to evaluate the performance of the modified s les. During this investigation, s les were prepared with 0.3% cellulose fiber, 0.2%, 0.3% 0.4%, and 0.5% CBs. The results of the CB-modified s les were compared with the s le with cellulose fiber and fresh bitumen (0% fiber). The results show that the physical and rheological properties of bitumen incorporating CBs improve significantly, and CBs could be used instead of virgin cellulose fiber as a fiber modifier.
Start Date: 07-2021
End Date: 07-2026
Amount: $5,000,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2019
End Date: 06-2025
Amount: $4,918,357.00
Funder: Australian Research Council
View Funded Activity