ORCID Profile
0000-0002-9451-2335
Current Organisation
London School of Hygiene and Tropical Medicine
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Publisher: BMJ
Date: 02-11-2017
DOI: 10.1136/ARCHDISCHILD-2017-313777
Abstract: We used national data to study differences in academic achievement between 5-year-old children with an isolated oral cleft and the general population. We also assessed differences by cleft type. Children born in England with an oral cleft were identified in a national cleft registry. Their records were linked to databases of hospital admissions (to identify additional anomalies) and educational outcomes. Z-scores (signed number of SD actual score is above national average) were calculated to make outcome scores comparable across school years and across six assessed areas ( personal development, communication and language, maths, knowledge of world, physical development and creative development ). 2802 children without additional anomalies, 5 years old between 2006 and 2012, were included. Academic achievement was significantly below national average for all six assessed areas with z-scores ranging from −0.24 (95% CI −0.32 to −0.16) for knowledge of world to −0.31 (−0.38 to −0.23) for personal development . Differences were small with only a cleft lip but considerably larger with clefts involving the palate. 29.4% of children were documented as having special education needs (national rate 9.7%), which varied according to cleft type from 13.2% with cleft lip to 47.6% with bilateral cleft lip and palate. Compared with national average, 5-year-old children with an isolated oral cleft, especially those involving the palate, have significantly poorer academic achievement across all areas of learning. These outcomes reflect results of modern surgical techniques and multidisciplinary approach. Children with a cleft may benefit from extra academic support when starting school.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-09-2017
DOI: 10.1126/SCISIGNAL.AAJ1978
Abstract: Mitochondria transduce the cytosolic Ca 2+ increase caused by plasma membrane injury into a ROS-dependent repair response.
Publisher: Elsevier BV
Date: 09-2004
Publisher: Oxford University Press (OUP)
Date: 07-09-2017
DOI: 10.1093/IJE/DYX177
Publisher: Wiley
Date: 04-01-2022
Abstract: To determine the association between ethnic group and risk of postpartum haemorrhage in women giving birth. Cohort study. Maternity units in England. A total of 981 801 records of births between 1 April 2015 and 31 March 2017 in a national clinical database. Multivariable logistic regression analyses with multiple imputation to account for missing data and robust standard errors to account for clustering within hospitals. Postpartum haemorrhage of ≥1500 ml (PPH). A total of 28 268 (2.9%) births were complicated by PPH. Risks were higher in women from black (3.9%) and other (3.5%) ethnic backgrounds. Following adjustment for maternal and fetal characteristics, and care at birth, there was evidence of an increased risk of PPH in women from all ethnic minority groups, with the largest increase seen in black women (adjusted OR 1.54, 95% CI 1.45–1.63). The increase in risk was robust to sensitivity analyses, which included changing the outcome to PPH of ≥3000 ml. In England, women from ethnic minority backgrounds have an increased risk of PPH, when maternal, fetal and birth characteristics are taken into account. Factors contributing to this increased risk need further investigation. Perinatal care for women from ethnic minority backgrounds should focus on preventative measures to optimise maternal outcomes. Women with an ethnic minority background giving birth in England have an increased risk of postpartum haemorrhage, even when characteristics of the mother, the baby and the care received are taken into account.
Publisher: Oxford University Press (OUP)
Date: 21-02-2017
DOI: 10.1093/HMG/DDX065
Publisher: Elsevier BV
Date: 07-2021
Publisher: Springer Science and Business Media LLC
Date: 25-06-2015
DOI: 10.1038/LEU.2015.162
Abstract: The TLX1 transcription factor is critically involved in the multi-step pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanism by which these T-cell specific oncogenes cooperate during transformation remains to be established. Here, we used chromatin immunoprecipitation followed by sequencing to establish the genome-wide binding pattern of TLX1 in human T-ALL. This integrative genomics approach showed that ectopic TLX1 expression drives repression of T cell-specific enhancers and mediates an unexpected transcriptional antagonism with NOTCH1 at critical target genes, including IL7R and NOTCH3. These phenomena coordinately trigger a TLX1-driven pre-leukemic phenotype in human thymic precursor cells, reminiscent of the thymus regression observed in murine TLX1 tumor models, and create a strong genetic pressure for acquiring activating NOTCH1 mutations as a prerequisite for full leukemic transformation. In conclusion, our results uncover a functional antagonism between cooperative oncogenes during the earliest phases of tumor development and provide novel insights in the multi-step pathogenesis of TLX1-driven human leukemia.
Publisher: Springer Science and Business Media LLC
Date: 11-11-2016
DOI: 10.1038/CDD.2016.127
Publisher: Springer Science and Business Media LLC
Date: 09-02-2016
Publisher: Elsevier BV
Date: 06-2021
Publisher: Springer Science and Business Media LLC
Date: 12-2020
Publisher: Springer Science and Business Media LLC
Date: 18-09-2014
DOI: 10.1038/LEU.2014.276
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Jan van der Meulen.