ORCID Profile
0000-0003-4680-9975
Current Organisations
University of Trento
,
University of Pisa
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Publisher: Elsevier BV
Date: 04-2013
DOI: 10.1016/J.MSEC.2012.11.038
Abstract: Since the 1970s, various types of ceramic, glass and glass-ceramic materials have been proposed and used to replace damaged bone in many clinical applications. Among them, hydroxyapatite (HA) has been successfully employed thanks to its excellent biocompatibility. On the other hand, the bioactivity of HA and its reactivity with bone can be improved through the addition of proper amounts of bioactive glasses, thus obtaining HA-based composites. Unfortunately, high temperature treatments (1200°C÷1300°C) are usually required in order to sinter these systems, causing the bioactive glass to crystallize into a glass-ceramic and hence inhibiting the bioactivity of the resulting composite. In the present study novel HA-based composites are realized and discussed. The s les can be sintered at a relatively low temperature (800 °C), thanks to the employment of a new glass (BG_Ca) with a reduced tendency to crystallize compared to the widely used 45S5 Bioglass®. The rich glassy phase, which can be preserved during the thermal treatment, has excellent effects in terms of in vitro bioactivity moreover, compared to composites based on 45S5 Bioglass® having the same HA/glass proportions, the s les based on BG_Ca displayed an earlier response in terms of cell proliferation.
Publisher: Frontiers Media SA
Date: 28-04-2015
Publisher: Springer Science and Business Media LLC
Date: 23-03-2012
DOI: 10.1007/S10856-012-4622-6
Abstract: A new protocol, based on a modified replication method, is proposed to obtain bioactive glass scaffolds. The main feature of these s les, named "shell scaffolds", is their external surface that, like a compact and porous shell, provides both high permeability to fluids and mechanical support. In this work, two different scaffolds were prepared using the following slurry components: 59 % water, 29 % 45S5 Bioglass(®) and 12 % polyvinylic binder and 51 % water, 34 % 45S5 Bioglass(®), 10 % polyvinylic binder and 5 % polyethylene. All the proposed s les were characterized by a widespread microporosity and an interconnected macroporosity, with a total porosity of 80 % vol. After immersion in a simulated body fluid (SBF), the scaffolds showed strong ability to develop hydroxyapatite, enhanced by the high specific surface of the porous systems. Moreover preliminary biological evaluations suggested a promising role of the shell scaffolds for applications in bone tissue regeneration. As regards the mechanical behaviour, the shell scaffolds could be easily handled without damages, due to their resistant external surface. More specifically, they possessed suitable mechanical properties for bone regeneration, as proved by compression tests performed before and after immersion in SBF.
Publisher: Elsevier BV
Date: 12-2019
DOI: 10.1016/J.JCIS.2019.09.058
Abstract: While nanomaterials are increasingly being proposed for contaminant remediation, a major challenge is how to develop high removal functionality while maintaining low cost and environmental friendliness. In this study, a hybrid reduced graphene oxide/iron nanoparticle (rGO/Fe NPs) was prepared via the in situ reduction of GO and FeCl
Publisher: Elsevier BV
Date: 07-2011
Publisher: Wiley
Date: 19-10-2010
DOI: 10.1002/PI.2954
Publisher: Elsevier BV
Date: 07-2010
Publisher: Elsevier BV
Date: 09-2014
DOI: 10.1016/J.MSEC.2014.05.047
Abstract: Presently, there is an increasing interest towards the composites of calcium phosphates, especially β-tricalcium phosphate (TCP), and bioactive glasses. In the present contribution, the recently developed BG_Ca/Mix glass has been used because its low tendency to crystallize allows to sinter the composites at relatively low temperature (i.e. 850°C), thus minimizing the glass devitrification and the interaction with TCP. A further improvement is the introduction of lab-produced TCP powders doped with specific ions instead of non-doped commercial powders, since the biological properties of materials for bone replacement can be modulated by doping them with certain metallic ions, such as Mg and Sr. Therefore, novel binary composites have been produced by sintering the BG_Ca/Mix glass with the addition of pure, Mg-substituted, Sr-substituted or Mg/Sr bisubstituted TCP powders. After an accurate characterization of the starting TCP powders and of the obtained s les, the composites have been used as three-dimensional supports for the culture of mouse calvaria-derived pre-osteoblastic cells. The s les supported cell adhesion and proliferation and induced promising mechanisms of differentiation towards an osteoblastic phenotype. In particular, the Mg/Sr bi-doped s les seemed to better promote the differentiation process thus suggesting a combined stimulatory effect of Mg(2+) and Sr(2+) ions.
Publisher: Elsevier BV
Date: 11-2010
No related grants have been discovered for Federica Chiellini.