ORCID Profile
0000-0002-4051-4327
Current Organisations
Technical University of Denmark
,
Danish Technical University
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Publisher: MDPI AG
Date: 09-12-2021
Abstract: γδ T cells are unique players in shaping immune responses, lying at the intersection between innate and adaptive immunity. Unlike conventional αβ T cells, γδ T cells largely populate non-lymphoid peripheral tissues, demonstrating tissue specificity, and they respond to ligands in an MHC-independent manner. γδ T cells display rapid activation and effector functions, with a capacity for cytotoxic anti-tumour responses and production of inflammatory cytokines such as IFN-γ or IL-17. Their rapid cytotoxic nature makes them attractive cells for use in anti-cancer immunotherapies. However, upon transformation, γδ T cells can give rise to highly aggressive lymphomas. These rare malignancies often display poor patient survival, and no curative therapies exist. In this review, we discuss the erse roles of γδ T cells in immune surveillance and response, with a particular focus on cancer immunity. We summarise the intriguing dichotomy between pro- and anti-tumour functions of γδ T cells in solid and haematological cancers, highlighting the key subsets involved. Finally, we discuss potential drivers of γδ T-cell transformation, summarising the main γδ T-cell lymphoma/leukaemia entities, their clinical features, recent advances in mapping their molecular and genomic landscapes, current treatment strategies and potential future targeting options.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 27-08-2019
DOI: 10.1126/SCISIGNAL.AAW3469
Abstract: By promoting noncanonical NF-κB signaling, SMAC mimetics can reprogram CD4 + T helper cell differentiation and curb autoimmunity.
Publisher: Wiley
Date: 27-05-2020
Publisher: American Society for Clinical Investigation
Date: 13-04-2020
DOI: 10.1172/JCI131241
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
Location: United States of America
No related grants have been discovered for Vasileios Bekiaris.