ORCID Profile
0000-0003-4814-6853
Current Organisation
University of Dublin Trinity College
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Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B923383K
Abstract: A series of substituted 1,4,7,10-tetraazacylcododecane ligands 1-4, possessing sensitizing nitrobenzene or naphthalene antennae, as one of the amide pendant arms, and their complexes with europium(III) were synthesised. The protonation constants and the metal ion stability constants of two of these ligands were determined by potentiometric titration. The pK(a) of the water molecules coordinated to the complexed metal ion were determined by both luminescent and potentiometric measurements. The luminescence pH dependence of a further three Eu(III) complexes, 5-7, which lack any antennae, were also studied with the aim of gaining a better understanding of the role of the metal bound water molecules in the luminescence properties of such complexes upon direct excitation of the lanthanide ion. The results from these luminescent measurements demonstrate that the Eu(III) emission was significantly modulated as a function of pH for all the complexes, which we assigned to changes occurring in the coordination environment of the ion within the cyclen system, caused by deprotonation of metal bound water molecules and/or deprotonation of pendent amide arms.
Publisher: American Chemical Society (ACS)
Date: 28-06-2017
Publisher: Elsevier BV
Date: 08-2003
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7DT01533J
Abstract: A flexible ditopic ligand 1 containing two N , N , O -tridentate (1,2,3-triazol-4-yl)-picolinamide chelating pockets is reported and the formation of multimetallic architectures is explored in the solid and the solution phase.
Publisher: Elsevier BV
Date: 04-2017
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01798K
Abstract: A humble norbornene functions as an ionic organogelator, forms aqueous biphasic and triphasic systems and assembles to form chiral helices.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC03316E
Abstract: Two chiral [2 × 2] tetranuclear Cu II square grid complexes are prepared from a (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand. Linkage isomerism through the amide is observed accompanying an in situ deprotonation and Cu I → Cu II oxidation process.
Publisher: Royal Society of Chemistry (RSC)
Date: 2006
DOI: 10.1039/B609923H
Abstract: The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.
Publisher: American Chemical Society (ACS)
Date: 08-2006
DOI: 10.1021/CM060603V
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CC17274G
Abstract: The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tröger's bases, are described these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CC07333J
Abstract: A novel 4-amino-1,8-naphthalimide derived Tröger's base ligand L has been synthesised and subsequently used in the formation of two new supramolecular coordination polymers TB-Co-CP and TB-Cd-CP .
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8OB02980F
Abstract: We report the synthesis of glycosylated naphthalimide compounds and their application as fluorescent probes for Concanavalin A (Con A) lectin.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6QI00498A
Abstract: A family of N -picolyl-1,8-napthalimide ligands display fascinating coordination chemistry and produce a series of robust and chemically responsive supramolecular metallo-gels.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7OB01835E
Abstract: We report here a novel one-pot synthetic strategy for the synthesis of a family of N -alkyl-1,8-naphthalimide derived Tröger's bases (in overall yield of 65–96%) via a nucleophilic substitution reaction.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC01584H
Abstract: Biological investigation of a new Tröger's base–Ru( ii )–curcumin conjugate is described.
Publisher: American Chemical Society (ACS)
Date: 12-10-2016
DOI: 10.1021/ACS.INORGCHEM.6B02137
Abstract: Two new luminescent ditopic naphthalimide-derived ligands, N-(4-cyanophenylmethylene)-4-(4-cyanophenoxy)-1,8-naphthalimide (L3) and N-(4-carboxyphenylmethylene)-4-(4-carboxyphenoxy)-1,8-naphthalimide (H
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0CC04303F
Abstract: The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
Publisher: American Chemical Society (ACS)
Date: 11-2005
DOI: 10.1021/OL051497Q
Abstract: [structure: see text] A new family of [3]polynorbornane frameworks exhibiting conformationally preorganized aromatic thiourea (cleft-like) receptors have been designed and synthesized for anion recognition. These show excellent affinity for the biologically relevant dihydrogenphosphate (H(2)PO(4)(-)) and dihydrogenpyrophosphate (H(2)P(2)O(7)(2)(-)) anions (among others), which are bound in 1:1 and 2:1 (host:anion) ratio, respectively. Moreover, visually striking color changes accompany guest binding, enabling this family to act as colorimetric anion sensors.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT01784K
Abstract: Pyrrolo[3,2- b ]pyrrole fluorophores are incorporated into metal–organic framework linkers, giving three-dimensional materials with responsive photoluminescence behaviour.
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B907037K
Abstract: The thiourea based 4-amino-1,8-naphthalimide molecules 1-5 were designed as fluorescent anion sensors and their photophysical properties investigated upon recognition of biologically relevant anions such as acetate, dihydrogen phosphate and fluoride in DMSO. Synthesised in a single step from their respective aniline precursors, 6-9, these molecules were designed on the fluorophore-spacer-receptor principle, where in the case of sensors 1-3 the thiourea anion recognition moieties were connected to the fluorophore via the 4-amino moiety, while sensors 4 and 5 had the thiourea moieties connected to the 'imide' via a CH2 spacer. The current study showed that 1-5 operated as photoinduced electron transfer (PET) sensors, as no significant changes were observed in their absorption spectra, while their fluorescence emissions were quenched upon recognition of ions such as AcO(-), H2PO4(-) and F(-), which demonstrates that bidirectional PET sensing occurs in such naphthalimide based anion sensors.
Publisher: Elsevier BV
Date: 08-2010
Publisher: Elsevier BV
Date: 12-2003
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4OB02384F
Abstract: Lanthanide( iii ) complexes of ‘pseudo’ dipeptide ligands and 3'-pyridine ligands have been characterised as metallo-ribonuclease mimics.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00091H
Abstract: Morpholine-substituted 1,8-naphthalimide fluorophores exhibit solvent and pH-dependent emission characteristics based on aggregation, and form robust chemically reversible metallogels.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8CE01756E
Abstract: The coordination chemistry of two 2-picolyl substituted bis-imide ligands is explored, revealing fascinating metallosupramolecular assemblies but an apparent barrier to chelation compared to monoimide congeners.
Publisher: Informa UK Limited
Date: 16-01-2012
Publisher: American Chemical Society (ACS)
Date: 13-08-2018
Abstract: meta-Phenylene bis(phenylurea) receptors 1-4 were designed and synthesized to investigate the association between receptor shape, anion-selective binding and anion-directed self-assembly processes. Solution studies, performed through
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CE00206H
Publisher: American Chemical Society (ACS)
Date: 20-09-2011
DOI: 10.1021/JA2061159
Abstract: The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind to DNA and undergo rapid cellular uptake, being localized within the cell cytoplasm and nucleus within 4 h.
Publisher: Elsevier BV
Date: 11-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6CC03092K
Abstract: Novel Ln( iii )-based hiphilic complexes with potential application as luminescent and MRI contrast agents, which self-assemble in aqueous solution into spherical micelles, are presented.
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B705560A
Abstract: The delayed lanthanide luminescence of the terbium [Tb(III)] diaryl-urea complex 1xTb is significantly enhanced upon sensing of dihydrogenphosphate (H2PO4(-)) in CH3CN, which occurs through multiple anion binding through hydrogen bonding interactions and potential metal ion coordination to Tb(III).
Publisher: Elsevier BV
Date: 12-2006
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3QO00232B
Abstract: The synthesis of chiral α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide ( tzpa ) ligands 4–6 designed by combining the coordination properties of two well-known ligand structures within a single unit is described.
Publisher: American Chemical Society (ACS)
Date: 16-07-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT04583F
Abstract: High nuclearity Ag( i ) assemblies are prepared from simple polytopic ligands, including an octanuclear metallomacrocycle which exhibits reversible and selective guest exchange.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6DT01416J
Abstract: Structural analysis of the 1,4-di(2-pyridyl)-1,2,3-triazole ligand and its transition metal complexes of varying lability demonstrate the coordination chemistry selectivity of this subtly unsymmetric ligand.
Publisher: Royal Society of Chemistry (RSC)
Date: 2008
DOI: 10.1039/B805610B
Abstract: Luminescent europium and terbium complexes and a mixed Eu(III)-Tb(III) complex were prepared, each with three macrocycles coordinating to a single lanthanide ion to form a trimetallic system, and can be used for the ratiometric sensing of anions in the case of the mixed complex.
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B703208K
Abstract: Three conformationally preorganised host molecules based on the [3]polynorbornyl framework and incorporating di-urea receptors were synthesised and their interaction with a series of anions investigated by (1)H NMR spectroscopy. A high affinity of each host molecule for dihydrogenphosphate (H(2)PO(4)(-)) and dihydrogenpyrophosphate (H(2)P(2)O(7)(2-)) was identified. In addition to binding to the urea receptors of the host molecules, evidence for an interaction involving the non-polar C-H groups within the binding cavity of the framework and guest anions was also discovered. Furthermore, an unusual 2 : 1 host-to-anion stoichiometry was indicated when binding H(2)P(2)O(7)(2-), and a model for the anion-mediated self-assembly of this complex species is proposed.
Publisher: American Chemical Society (ACS)
Date: 21-04-2007
DOI: 10.1021/OL070339R
Abstract: The design, synthesis, and characterization of a novel dinuclear Eu(III) bismacrocyclic conjugate 1.Eu2 as a delayed luminescent lanthanide sensor for dicarboxylates is discussed. The sensor was shown to bind small dicarboxylic acids such as aspartic, malonic, succinic, or glutaric acid in pH 6.5 solutions. However, only malonic acid gave rise to selective Eu(III) luminescent enhancements, as the emission was reduced for all of the other acids.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3OB00737E
Abstract: Herein the synthesis of 1,8-naphthalimides functionalised as the 3,4-dihydroxy-1,8-naphthalimide (catechol, Nap-Cat) and the corresponding 15-crown-5 (Nap-Crown) is reported.
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B910560N
Abstract: This critical review focuses on the development of anion sensors, being either fluorescent and/or colorimetric, based on the use of the 1,8-naphthalimide structure a highly versatile building unit that absorbs and emits at long wavelengths. The review commences with a short description of the most commonly used design principles employed in chemosensors, followed by a discussion on the photophysical properties of the 4-amino-1,8-naphthalimide structure which has been most commonly employed in both cation and anion sensing to date. This is followed by a review of the current state of the art in naphthalimide-based anion sensing, where systems using ureas, thioureas and amides as hydrogen-bonding receptors, as well as charged receptors have been used for anion sensing in both organic and aqueous solutions, or within various polymeric networks, such as hydrogels. The review concludes with some current and future perspectives including the use of the naphthalimides for sensing small biomolecules, such as amino acids, as well as probes for incorporation and binding to proteins and for the recognition/sensing of polyanions such as DNA, and their potential use as novel therapeutic and diagnostic agents (95 references).
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NR05598A
Abstract: The development of 15 nm (average size) Ru( ii ) functionalized gold nanoparticles 1–3·AuNP is described.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CC03482B
Abstract: A heterotopic naphthalimide ligand N -(4-picolyl)-4-(4′-carboxyphenoxy)-1,8-naphthalimide HL is utilised for the formation of self-assembled soft materials.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2DT00020B
Abstract: The new Ru(II) polypyridyl complex 1 was synthesised using microwave irradiation from the new polypyridyl ligand 2'DipyTAP', and its photophysical properties, and DNA binding abilities were investigated using various spectroscopic techniques and 1 was shown to act as a 'NIR molecular light switch' for DNA with an emission window between 680 and 860 nm.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8QM00182K
Abstract: The 4-pyridonyl group is explored as a substituent for 1,8-naphthalimides, revealing interesting structural chemistry and photoluminescence behaviour in crystalline materials.
Publisher: Elsevier BV
Date: 09-2005
Publisher: American Chemical Society (ACS)
Date: 18-10-2006
DOI: 10.1021/IC0614418
Abstract: The synthesis and photophysical properties of a coordinatively unsaturated cationic dinuclear terbium complex, 2.Tb(2), that can detect the presence of mono- or bis(carboxylates) in buffered aqueous solution at physiological pH is described. Full ligand synthesis and structural characterization of 2.Na(2) are also described. Spectroscopic measurements determined that each Tb(III) metal center has two metal-bound water molecules (q = 2). The recognition or sensing of N,N-dimethylaminocarboxylic acid, 4, and the bis(carboxylate) terephthalic acid, 5, which can also function as sensitizing antennae, was found to occur through the binding of these carboxylates to the metal center via the displacement of the metal bound water molecules. This gave rise to the formation of luminescent ternary complexes in solution in 2:1 or 1:1 (ion:2.Tb(2)) stoichiometry, respectively. Aliphatic bis(carboxylates) also bind to 2.Tb(2) where the selectivity for the ion recognition and stoichiometry was dictated by the structure of the anion, being most selective for pimelic acid, 6. Binding of either l- or d-tartaric acid gave rise to the formation ternary complex formation, with 2:1 stoichiometry, where the ion recognition resulted in quenching of the lanthanide emission.
Publisher: Springer Science and Business Media LLC
Date: 05-2005
DOI: 10.1007/S10895-005-2627-Y
Abstract: This mini review highlights the synthesis and photophysical evaluation of anion sensors, for nonaqueous solutions, that have been developed in our laboratories over the last few years. We have focused our research mainly on developing fluorescent photoinduced electron transfer (PET) sensors based on the fluorophore-spacer-anion receptor principle using several anthracene (emitting in the blue) and 1,8-naphthalimide (emitting in the green) fluorophores, with the aim of targeting biologically and industrially relevant anions such as acetates, phosphate and amino acids, as well as halides such as fluoride. The receptors and the fluorophore are separated by a short methyl or ethyl spacer, where the charge neutral anion receptors are either aliphatic or aromatic urea (or thiourea) moieties. For these, the anion recognition is through hydrogen bonding, yielding anion:receptor complexes. Such bonding gives rise to enhanced reduction potential in the receptor moieties which causes enhancement in the rate of PET quenching of the fluorophore excited state from the anion:receptor moiety. This design can be further elaborated on by incorporating either two fluorophores, or urea/thiourea receptors into the sensor structures, using anthracene as a fluorophore. For the latter design, the sensors were designed to achieve sensing of bis-anions, such as di-carboxylates or pyrophosphate, where the anion bridged the anthracene moiety. In the case of the naphthalimide based mono-receptor based PET sensors, it was discovered that in DMSO the sensors were also susceptible to deprotonation by anions such as F(-) at high concentrations. This led to substantial changes in the absorption spectra of these sensors, where the solution changed colour from yellow/green to deep blue, which was clearly visible to the naked eye. Hence, some of the ex les presented can act as dual fluorescent-colorimetric sensors for anions. Further investigations into this phenomenon led to the development of simple colorimetric sensors for fluorides, which upon exposure to air, were shown to fix carbon dioxide as bicarbonate.
Publisher: American Chemical Society (ACS)
Date: 23-05-2006
DOI: 10.1021/OL060752J
Abstract: [reaction: see text] The synthesis of the novel Eu(III) cyclen complex, Eu1, is described. In buffered pH 7.4 water, the Eu(III) emission was "switched on" upon excitation of the Terpy antenna. In the presence of various transition-metal ions (e.g., Fe(II) and Ni(II)), both the singlet-excited state and the Eu(III) emission were quenched ("switched off"), whereas in the ground state, an MLCT band was formed, signifying the formation of stable mixed linear trimetallic f-d supramolecular self-assemblies.
Publisher: American Chemical Society (ACS)
Date: 26-09-2000
DOI: 10.1021/JA001797X
Publisher: American Chemical Society (ACS)
Date: 28-07-2016
Publisher: American Chemical Society (ACS)
Date: 06-03-2018
DOI: 10.1021/ACS.INORGCHEM.8B00080
Abstract: The synthesis of the three-dimensional metal-organic framework material, [Zn
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0CS90020F
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0DT01421D
Abstract: Triazolylpicolinamide (tzpa) ligands give a robust metallogel or a crystalline coordination network as a structural model on reaction with silver( i ).
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B611487C
Abstract: The synthesis and the photophysical evaluation of a novel pH dependent lanthanide luminescent self-assembly in water between a cyclen based europium complex and a beta-diketonate is described and its use as a luminescent sensor in displacement assays for anions such as acetate, bicarbonate and lactate, where the Eu(III) emission was quenched upon anion recognition.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8DT00439K
Abstract: Porous cadmium coordination polymers are prepared from structurally related benzenetricarboxamide ligands, and the functional influence of these scaffolds is examined.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0OB00033G
Abstract: The investigation into the self-assembly formation of the glycan based 4-amino- and 4-bromo-1,8-naphthalimide ( Nap ) structures 1–3 is presented.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Thorfinnur Gunnlaugsson.