ORCID Profile
0000-0001-7030-2686
Current Organisations
University of Duisburg-Essen
,
University of Queensland
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Publisher: Public Library of Science (PLoS)
Date: 26-04-2016
Publisher: Georg Thieme Verlag KG
Date: 07-2002
DOI: 10.1055/S-2002-33285
Abstract: The present study describes clinical and epidemiological data of patients with malignomas of the head and neck documented in the Munich Cancer Register. Data of head and neck cancer patients treated at four departments of head and neck surgery and one of oral-maxillo-facial surgery in the area of Munich from 1978 up to now are reported. Incidence and mortality as a function of age, sex, and tumor localization are described in comparison to clinical and epidemiological data as specified in tumor registers of the Saarland and the USA. Moreover, TNM stages, survival, recurrence, and metastasis rates are presented. Based on the documentation of the Munich Cancer Register our study is the first to present a detailed description of clinical and epidemiological data of patients suffering from head and neck malignomas.
Publisher: Springer Science and Business Media LLC
Date: 15-06-2011
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TB01337A
Abstract: Floating tablets were prepared using hydrophobic (curcumin) and hydrophilic (captopril) drug loaded mesoporous silica nanoparticles respectively, leading to an improved dissolution rate of curcumin and controlled release for captopril.
Publisher: Elsevier BV
Date: 06-2012
DOI: 10.1016/J.JCIS.2012.03.014
Abstract: A new and facile approach has been developed to prepare monodisperse mesoporous silica nanospheres (MMSNs) with controlled particle sizes and pore structures. In our approach, MMSNs were synthesized simply in a sodium acetate solution without adding any other alkali or alcohol additives. MMSNs have a spherical shape and uniform particle sizes, which can be adjusted from 50 to 110 nm by increasing the reaction temperature from 40 to 80 °C. By performing a subsequent hydrothermal treatment (HT) under basic condition (pH=~11.5) at 130 °C, the mesoporous pore volume and surface area can be enhanced, while keeping the mono-dispersion characteristics and the mesopore size almost unchanged. The pore sizes of MMSNs can be adjusted from 2.8 to 4.0 nm under acidic solutions by changing the HT temperature from 100 to 130 °C. The formation process of MMSNs has been investigated by transmission electron microscopy (TEM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) techniques. A spherical micelle templating mechanism is proposed to explain the formation of MMSNs in our system, which is different from that of traditional highly ordered mesoporous silica nanoparticles (MCM-41).
Publisher: American Chemical Society (ACS)
Date: 02-05-2017
DOI: 10.1021/JACS.6B12622
Abstract: Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. The tail length and tail coverage on head particles are adjustable. Compared to spherical silica nanoparticles with a solid structure (Stöber spheres) or large-pore symmetrical MSNs with fully covered tails, asymmetrical head-tail MSNs (HTMSNs) show superior hemocompatibility due to reduced membrane deformation of red blood cells and decreased level of reactive oxygen species. Moreover, compared to Stöber spheres, asymmetrical HTMSNs exhibit a higher level of uptake and in vitro maturation of immune cells including dendritic cells and macrophage. This study has provided a new family of nanocarriers with potential applications in vaccine development and immunotherapy.
Publisher: Elsevier BV
Date: 11-2018
DOI: 10.1016/J.JCIS.2018.06.031
Abstract: A solvothermal-assisted evaporation-induced self-assembly (SA-EISA) approach has been developed for the synthesis of ordered mesoporous alumina (OMA) materials with high thermal stability and improved performance in catalysis. In conventional EISA process, the evaporation step is accompanied by the hydrolysis of organic aluminum precursors, thus the evaporation conditions have significant influences on the reaction and the final structure of OMA. In our approach, the solvothermal treatment step promotes the complete hydrolysis of aluminum precursors and produces partially condensed cluster-like aluminum hydroxyl species, which allows the formation of OMA in a broad range of evaporation conditions. Compared to mesoporous alumina obtained by conventional EISA process, OMA materials prepared by SA-EISA approach exhibit higher specific surface area, pore volume and thermal stability. When used as supporting materials for vanadium oxide catalyst, OMA materials obtained by the SA-EISA approach exhibit excellent activity, selectivity and stability for ethylbenzene dehydrogenation with carbon dioxide as a mild oxidant. Our contribution has provided new understanding in the synthesis of OMA materials with improved performance for catalytic applications.
Publisher: Springer Science and Business Media LLC
Date: 04-2010
Abstract: The cooperative self-assembly of organic–inorganic siliceous composite structures has been studied from the aspect of inorganic precursors. We reveal that the vesicular or mesostructured materials can be obtained selectively by just changing the silica sources in one templating system. For poly(ethylene oxide)-type block copolymers with either poly(propylene oxide) or poly(butylene oxide) as the hydrophobic moieties, when the other synthesis parameters are exactly the same, the use of tetramethyl orthosilicate (TMOS) as a silica source gives rise to highly ordered mesostructures, while the use of tetraethyl orthosilicate (TEOS) leads to vesicles or foams. The attenuated total reflection Fourier transform infrared (ATR-FTIR) technique is used to monitor the silicate species derived from the hydrolysis and condensation of TMOS and TEOS as a function of the reaction time. On the basis of the ATR-FTIR results, we propose a “differentiating effect” at relatively high pH (4.7) to interpret the influence of different silica sources on the self-organized composite structures. For comparison, a “leveling effect” at relatively low pH (strong acidic conditions) is revealed to explain that both TMOS and TEOS lead to the same mesostructures. Our contribution provides a feasible and designable method to synthesize from conventional ordered mesostructures to novel vesicular structures, which are significant for their future practical applications.
Publisher: MDPI AG
Date: 05-11-2016
DOI: 10.3390/NANO6110201
Publisher: American Chemical Society (ACS)
Date: 15-12-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TA01281H
Abstract: This paper presents the synthesis of biphenyl bridged dendritic mesoporous organosilica nanoparticles (BDMONs) and the important role of biphenyl groups in the adsorption of pyrene.
Publisher: MDPI AG
Date: 29-10-2021
DOI: 10.3390/ANTIBIOTICS10111324
Abstract: Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against Escherichia coli (E. coli) and Staphylococcus epidermidis (S. epidermidis). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications.
Publisher: American Chemical Society (ACS)
Date: 22-01-2010
DOI: 10.1021/LA9041698
Abstract: The analysis of peptides by the mass spectrometry (MS) technique is important in modern life science. The enrichment of peptides can increase the detection efficiency and is sometimes indispensable for collecting the information on proteins with low-abundance. Herein, we first report that functionalized periodic mesoporous organosilica (PMO) materials have a superior peptide enrichment property. It is demonstrated that the PMO materials with an organo-bridged (-CH(2)-) hybrid wall composition display a highly enhanced peptide enrichment ability compared to the pure silica material (SBA-15) with similar mesostructured parameters and morphology. More importantly, by surface modification of PMO with amino groups (denoted NH(2)-PMO), PMO and NH(2)-PMO with opposite charged surfaces (-25.2 and +39.0 mV, respectively) show selective affinities for positively and negatively charged peptides, respectively. By directly adding PMO, NH(2)-PMO as well as pure silica materials to the peptides solution with a low concentration (1-2 fmol/microL), 36 and 28 peptides can be detected from the BSA digestion in the presence of PMO and NH(2)-PMO, respectively, while only 6 and 4 are monitored in the case of SBA-15 enrichment and from solution without enrichment, respectively. Moreover, 69.4% (25 of 36) of enriched peptides by PMO have pI > or = 6 and 80% (21 of 28) of enriched peptides by NH(2)-PMO possess pI < or = 6. Combining the results from the NH(2)-PMO and PMO enrichment together, 51 peptides can be identified with a MOWSE score of 333. It is also noted that similar conclusions can also be obtained from the peptides solution originated from other proteins. This might be an important contribution to the understanding of the interaction between peptides and porous hosts, and the proposed method is promising for the development of both material science and biotechnology.
Publisher: Wiley
Date: 15-08-2013
Abstract: Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm).
Publisher: Public Library of Science (PLoS)
Date: 05-01-2016
Publisher: Springer Science and Business Media LLC
Date: 10-11-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4NR00633J
Abstract: A novel combo-pore approach has been designed for the programmable purification, minimisation of s le complexity, enrichment and sensitive detection of peptides in bios les.
Publisher: American Chemical Society (ACS)
Date: 25-01-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NR01574B
Abstract: A facile spray drying technique has been developed for large-scale and template-free production of nanoporous silica with controlled morphology, large pore size, and high pore volume, using commercially available fumed silica, Aerosil 200, as a sole precursor. This approach can be applied to the preparation of functional nanoporous materials, in this study, lanthanum oxide functionalised silica microspheres by introducing lanthanum nitrate in situ during the spray drying process and followed by a post-calcination process. The resultant lanthanum functionalised Aerosil microspheres manifest high phosphate adsorption capacity (up to 2.317 mmol g(-1)), fast kinetics, and excellent adsorption performance at a low phosphate concentration (1 mg L(-1)). In virtue of the easy and scalable synthesis method, low cost and high performances of the product, the materials we reported here are promising for water treatment. Our approach may be general and extended to the synthesis of other functional nanoporous materials with versatile applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5TB01405K
Abstract: Silica nanoparticles with controllable surface roughness have been successfully prepared for therapeutic anti-pAkt antibody delivery.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5TA06129F
Abstract: Nitrogen-doped ordered mesoporous carbon single crystals have been synthesized. The resultant material shows high specific capacitance, excellent rate performance, and outstanding cycling stability in EDLCs.
Publisher: American Chemical Society (ACS)
Date: 15-05-2013
DOI: 10.1021/JA402463H
Abstract: A facile vacuum-assisted vapor deposition process has been developed to control the pore size of ordered mesoporous silica materials in a stepwise manner with angstrom precision, providing an unprecedented paradigm for screening a designer hydrophobic drug nanocarrier with optimized pore diameter to maximize drug solubility.
Publisher: Springer Science and Business Media LLC
Date: 28-12-2015
Publisher: American Chemical Society (ACS)
Date: 10-12-2015
Publisher: American Association for the Advancement of Science (AAAS)
Date: 06-10-2023
Publisher: American Chemical Society (ACS)
Date: 13-05-2016
DOI: 10.1021/JACS.6B00243
Abstract: Nature's creations with spiky topological features typically exhibit intriguing surface adhesive properties. From micrometer-sized pollen grains that can easily stick to hairy insects for pollination to nanoscale virus particles that are highly infectious toward host cells, multivalent interactions are formed taking advantage of rough surfaces. Herein, this nature-inspired concept is employed to develop novel drug delivery nanocarriers for antimicrobial applications. A facile new approach is developed to fabricate silica nanopollens (mesoporous silica nanospheres with rough surfaces), which show enhanced adhesion toward bacteria surfaces compared to their counterparts with smooth surfaces. Lysozyme, a natural antimicrobial enzyme, is loaded into silica nanopollens and shows sustained release behavior, potent antimicrobial activity, and long-term total bacterial inhibition up to 3 days toward Escherichia coli. The potent antibacterial activity of lysozyme-loaded silica nanopollens is further demonstrated ex vivo by using a small-intestine infection model. Our strategy provides a novel pathway in the rational design of nanocarriers for efficient drug delivery.
Publisher: American Chemical Society (ACS)
Date: 31-08-2015
Publisher: Wiley
Date: 03-08-2016
Abstract: Intracellular delivery of proteins is a promising strategy of intervention in disease, which relies heavily on the development of efficient delivery platforms due to the cell membrane impermeability of native proteins, particularly for negatively charged large proteins. This work reports a vesicle supra-assembly approach to synthesize novel amine-functionalized hollow dendritic mesoporous silica nanospheres (A-HDMSN). An amine silica source is introduced into a water-oil reaction solution prior to the addition of conventional silica source tetraethylorthosilicate. This strategy favors the formation of composite vesicles as the building blocks which further assemble into the final product. The obtained A-HDMSN have a cavity core of ≈170 nm, large dendritic mesopores of 20.7 nm in the shell and high pore volume of 2.67 cm
Publisher: Wiley
Date: 24-07-2014
Abstract: A rationally designed two-step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano-carriers for cellular delivery applications of therapeutical biomolecules.
Publisher: American Chemical Society (ACS)
Date: 11-09-2017
Publisher: Springer Science and Business Media LLC
Date: 11-03-2011
DOI: 10.1557/JMR.2010.98
Publisher: Wiley
Date: 02-02-2016
Publisher: The American Association of Immunologists
Date: 08-2020
Abstract: East Coast fever (ECF), caused by Theileria parva, is the most important tick-borne disease of cattle in sub-Saharan Africa. Practical disadvantages associated with the currently used live-parasite vaccine could be overcome by subunit vaccines. An 80-aa polypeptide derived from the C-terminal portion of p67, a sporozoite surface Ag and target of neutralizing Abs, was the focus of the efforts on subunit vaccines against ECF and subjected to several vaccine trials with very promising results. However, the vaccination regimen was far from optimized, involving three inoculations of 450 μg of soluble p67C (s-p67C) Ag formulated in the Seppic adjuvant Montanide ISA 206 VG. Hence, an improved formulation of this polypeptide Ag is needed. In this study, we report on two nanotechnologies that enhance the bovine immune responses to p67C. In idually, HBcAg-p67C (chimeric hepatitis B core Ag virus-like particles displaying p67C) and silica vesicle (SV)–p67C (s-p67C adsorbed to SV-140-C18, octadecyl-modified SVs) adjuvanted with ISA 206 VG primed strong Ab and T cell responses to p67C in cattle, respectively. Coimmunization of cattle (Bos taurus) with HBcAg-p67C and SV-p67C resulted in stimulation of both high Ab titers and CD4 T cell response to p67C, leading to the highest subunit vaccine efficacy we have achieved to date with the p67C immunogen. These results offer the much-needed research depth on the innovative platforms for developing effective novel protein-based bovine vaccines to further the advancement.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7TA04477A
Abstract: Aluminum-ion batteries with a new monolithic nanoporous graphene cathode and a novel coin-cell configuration have been developed and delivered superior performance.
Publisher: Elsevier BV
Date: 08-2018
DOI: 10.1016/J.BIOMATERIALS.2018.05.025
Abstract: Silica based nanoparticles have emerged as a promising vaccine delivery system for cancer immunotherapy, but their bio-degradability, adjuvanticity and the resultant antitumor activity remain to be largely improved. In this study, we report biodegradable glutathione-depletion dendritic mesoporous organosilica nanoparticles (GDMON) with a tetrasulfide-incorporated framework as a novel co-delivery platform in cancer immunotherapy. Functionalized GDMON are capable of co-delivering an antigen protein (ovalbumin) and a toll-like receptor 9 (TLR9) agonist into antigen presenting cells (APCs) and inducing endosome escape. Moreover, decreasing the intracellular glutathione (GSH) level through the -S-S-/GSH redox chemistry increases the ROS generation level both in vitro and in vivo, facilitating cytotoxic T lymphocyte (CTL) proliferation and reducing tumour growth in an aggressive B16-OVA melanoma tumour model. Our results have shown the potential of GDMON as a novel self-adjuvant and co-delivery nanocarrier for cancer vaccine.
Publisher: Frontiers Media SA
Date: 18-01-2021
DOI: 10.3389/FBIOE.2020.606652
Abstract: Development of veterinary subunit vaccines comes with a spectrum of challenges, such as the choice of adjuvant, antigen delivery vehicle, and optimization of dosing strategy. Over the years, our laboratory has largely focused on investigating silica vesicles (SVs) for developing effective veterinary vaccines for multiple targets. Rhipicephalus microplus (cattle tick) are known to have a high impact on cattle health and the livestock industry in the tropical and subtropical regions. Development of vaccine using Bm86 antigen against R. microplus has emerged as an attractive alternative to control ticks. In this study, we have investigated the biodistribution of SV in a live animal model, as well as further explored the SV ability for vaccine development. Rhodamine-labeled SV-140-C 18 (Rho-SV-140-C 18 ) vesicles were used to adsorb the Cy5-labeled R. microplus Bm86 antigen (Cy5-Bm86) to enable detection and characterization of the biodistribution of SV as well as antigen in vivo in a small animal model for up to 28 days using optical fluorescence imaging. We tracked the in vivo biodistribution of SVs and Bm86 antigen at different timepoints (days 3, 8, 13, and 28) in BALB/c mice. The biodistribution analysis by live imaging as well as by measuring the fluorescent intensity of harvested organs over the duration of the experiment (28 days) showed greater accumulation of SVs at the site of injection. The Bm86 antigen biodistribution was traced in lymph nodes, kidney, and liver, contributing to our understanding how this delivery platform successfully elicits antibody responses in the groups administered antigen in combination with SV. Selected tissues (skin, lymph nodes, spleen, kidney, liver, and lungs) were examined for any cellular abnormalities by histological analysis. No adverse effect or any other abnormalities were observed in the tissues.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SC02961C
Abstract: Designed Janus silica nanoparticles can stimulate stronger phagocytosis and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.
Publisher: Wiley
Date: 05-03-2014
Abstract: A unique combined pore approach to the sensitive detection of human insulin is developed. Through a systematic study to understand the impact of pore size and surface chemistry of nanoporous materials on their enrichment and purification performance, the advantages of selected porous materials are integrated to enhance detection sensitivity in a unified two-step process. In the first purification step, a rationally designed large pore material (ca. 100 nm in diameter) is chosen to repel the interferences from nontarget molecules. In the second enrichment step, a hydrophobically modified mesoporous material with a pore size of 5 nm is selected to enrich insulin molecules. A low detection limit of 0.05 ng mL(-1) in artificial urine is achieved by this advanced approach, similar to most antibody-based analysis protocols. This designer approach is efficient and low cost, and thus has great potential in the sensitive detection of biomolecules in complex biological systems.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5TB01911G
Abstract: The contribution of the surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery, including adsorption, sustained release, cellular uptake and endo/lysosomal escape.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4RA12553C
Abstract: The Temperature-controlled phase transformation from hexagonal mesostructure silica (HMS) to macroporous ordered siliceous foams (MOSF). HMS and MOSF exhibit higher VOCs removal capacity and recyclability compared to silica gel and activated carbon.
Publisher: Elsevier BV
Date: 12-2022
DOI: 10.1016/J.JCIS.2022.08.038
Abstract: Cellular delivery of DNA using silica nanoparticles has attracted great attention. Typically, polyethyleneimine (PEI) is used to form a silica/PEI composite vector. Understanding the interactions at the silica and PEI interface is important for successful DNA delivery and transfection, especially for silica with different surface functionality. Herein, we report that a higher content of hydrogen boning formed between PEI molecules and phosphonate modified silica nanoparticles could slow down the PEI dissolution from the freeze-dried solid composites into aqueous solution than the bare silica counterpart. The pronounced PEI retention ability through phosphonation of silica nanoparticles effectively improves the transfection efficiency due to the high DNA binding affinity extracellularly, effective lysosome escape and high nuclear entry of both PEI and DNA intracellularly. Our study provides a fundamental understanding on designing effective silica-PEI-based nano-vectors for DNA delivery applications.
Publisher: American Scientific Publishers
Date: 2010
Abstract: Various siliceous nanostructures have been successfully synthesized through the co-organization of organic molecules and inorganic silica source under mild pH conditions (pH approximately 5). A biodegradable block copolymer P123 [EO20PO70EO20, EO is poly (ethylene oxide), PO is poly (propylene oxide)] is employed as a marcomolecular template and Na2SiO39H2O as a silica source. By changing the concentrations of the reactants and/or reaction temperature, siliceous multilamellar vesicles, unilamellar nano-foams and multilamellar vesicles with sponge-like walls have been obtained. Our work provides a convenient and bioinspired route to obtain siliceous nanostructured materials with adjustable and multi-level pore structures as well as rich morphologies, which is important to understand the biomineralization mechanism. Such artificial silica nanoporous materials may find potential applications in catalysis, separations, electronics, and photonics, etc.
Publisher: Wiley
Date: 04-02-2015
Abstract: Large pore (4.6-7.6 nm) and well-dispersed benzene bridged mesoporous organosilica nanoparticles with uniform particle size of ≈50 nm are prepared via a biphasic approach. They can be directly used as nanocarriers without surface modification for the intracellular delivery of therapeutic proteins.
Publisher: American Chemical Society (ACS)
Date: 19-03-2019
Abstract: Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g
Publisher: Elsevier BV
Date: 12-2014
DOI: 10.1016/J.BIOMATERIALS.2014.08.044
Abstract: Bovine Viral Diarrhoea Virus (BVDV) is widely distributed in cattle industries and causes significant economic losses worldwide annually. A limiting factor in the development of subunit vaccines for BVDV is the need to elicit both antibody and T-cell-mediated immunity as well as addressing the toxicity of adjuvants. In this study, we have prepared novel silica vesicles (SV) as the new generation antigen carriers and adjuvants. With small particle size of 50 nm, thin wall (~6 nm), large cavity (~40 nm) and large entrance size (5.9 nm for SV-100 and 16 nm for SV-140), the SV showed high loading capacity (∼ 250 μg/mg) and controlled release of codon-optimised E2 (oE2) protein, a major immunogenic determinant of BVDV. The in vivo functionality of the system was validated in mice immunisation trials comparing oE2 plus Quil A (50 μg of oE2 plus 10 μg of Quil A, a conventional adjuvant) to the oE2/SV-140 (50 μg of oE2 adsorbed to 250 μg of SV-140) or oE2/SV-140 together with 10 μg of Quil A. Compared to the oE2 plus Quil A, which generated BVDV specific antibody responses at a titre of 10(4), the oE2/SV-140 group induced a 10 times higher antibody response. In addition, the cell-mediated response, which is essential to recognise and eliminate the invading pathogens, was also found to be higher [1954-2628 spot forming units (SFU)/million cells] in mice immunised with oE2/SV-140 in comparison to oE2 plus Quil A (512-1369 SFU/million cells). Our study has demonstrated that SV can be used as the next-generation nanocarriers and adjuvants for enhanced veterinary vaccine delivery.
Publisher: Public Library of Science (PLoS)
Date: 02-12-2015
Publisher: Wiley
Date: 06-2020
DOI: 10.1002/EOM2.12028
Publisher: Wiley
Date: 10-2015
Abstract: A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm(3) g(-1). MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4CC00620H
Abstract: Programme Me! Programmable mesoporous silica based nanoparticles are produced via a combination of an amino modified surface and a coating of bio-responsive soy protein.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01054D
Abstract: An aluminum–selenium battery powered by the reversible redox reaction of Se/Se 2 Cl 2 has been developed for the first time.
Publisher: Wiley
Date: 03-05-2017
Abstract: Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.
Publisher: Wiley
Date: 05-04-2013
Abstract: The confinement of phosphates inside adsorbents is important for not only entrophication control, but also the recovery of phosphorous, a depleting natural resource. However, the behaviour of chemisorbed phosphates inside nanoporous materials has not been systematically studied. Here, the confinement of chemisorbed phosphates in a three-dimensional cubic mesoporous material with adjustable structural parameters is systematically investigated. By taking advantage of advanced electron tomography techniques, the relationship between the growth of chemisorbed phosphates, the overall phosphate-adsorption performance and the mesostructural parameters is revealed. Cubic cage-type FDU-12 materials with tuneable entrance sizes were prepared and functionalised with different amounts of lanthanum oxide. When the entrance size is smaller than approximately 5 nm, phosphates are found only in isolated cages, thereby leading to low lanthanum (La) usage efficiency and phosphate removal capacity. When the entrance size is increased, chemisorption occurs in both cages and entrances, thus forming crystalline LaPO4 nanorods and increasing both the La usage efficiency and the phosphate removal capacity. In addition, the LaPO4 nanorods show a preferential orientation along the [110] direction. This study provides new insights in the rational design of phosphate adsorbents with controlled structures and high performance.
Publisher: American Chemical Society (ACS)
Date: 21-11-2006
DOI: 10.1021/JA066707O
Abstract: We report a new approach to produce macroporous ( approximately 110 nm in diameter) ordered siliceous foams (MOSF) by using block copolymers as templates in the absence of any organic cosolvent. The fine three-dimensional honeycomb structure of MOSF was determined by electron tomography. A formation mechanism of MOSF that spans from the atomic to macroscopic scale is proposed, which involves the cooperative self-assembly of unilamellar vesicles followed by the supra-assembly of vesicles. The fusion of soft vesicles finally leads to MOSF with well-ordered and defined honeycomb structures.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TB00595C
Abstract: SBA-15 rods with 80–200 nm in length and 18 ± 8 nm in width have been prepared, showing enhanced cellular uptake efficiency.
Publisher: Elsevier BV
Date: 06-2022
Publisher: American Chemical Society (ACS)
Date: 12-04-2018
DOI: 10.1021/ACS.LANGMUIR.8B00377
Abstract: The insulin immobilization behaviors of silica vesicles (SV) before and after modification with hydrophobic alkyl -C
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9EN01123D
Abstract: Silica nanoadsorbents with a gradient of sulfur content with higher density at the external part enable effective decontamination of mercury.
Publisher: American Chemical Society (ACS)
Date: 27-10-2009
DOI: 10.1021/CM901999N
Publisher: Elsevier BV
Date: 2017
DOI: 10.1016/J.VACCINE.2016.11.037
Abstract: Anaplasma marginale is a devastating tick-borne pathogen causing anaplasmosis in cattle and results in significant economic loss to the cattle industry worldwide. Currently, there is no widely accepted vaccine against A. marginale. New generation subunit vaccines against A. marginale, which are much safer, more efficient and cost-effective, are in great need. The A. marginale outer membrane protein VirB9-1 is a promising antigen for vaccination. We previously have shown that soluble recombinant VirB9-1 protein can be expressed and purified from Escherichia coli and induce a high level of humoral and cellular immunity in mice. In this study, we re-formulated the nanovaccines using the partially-purified VirB9-1 protein as the antigen and hollow nano-size silica vesicles (SV-100) as the adjuvant. We simplified the purification method to obtain the partially-purified antigen VirB9-1 with a six-fold higher yield. The new formulations using the partially-purified VirB9-1 protein achieved higher antibody and cell-mediated immune responses compared to the purified ones. This finding suggests that the partially-purified VirB9-1 protein performs better than the purified ones in the vaccination against A. marginale, and a certain level of contaminants in the protein antigen can be self-adjuvant and boost immunogenicity together with the nanoparticle adjuvant. This may lead to finding a "Goldilocks" level of contaminants. The new nanovaccine formulation using partially-purified antigens along with nanoparticle adjuvants offers an alternative strategy for making cheaper veterinary vaccines.
Publisher: Elsevier BV
Date: 2019
DOI: 10.1016/J.CHEMOSPHERE.2018.10.071
Abstract: Developing highly effective adsorbents for efficient decontamination of organic pollutants from water is an evasive aim for community well-being and environmental protection. Here, we report the successful fabrication of dendritic mesoporous carbon nanoparticles (DMCNs) as an advantageous adsorbent for ultrahigh and fast adsorption of anthracene. Dendritic mesoporous organosilica nanoparticles with an octadecyl-rich framework were utilized to synthesize DMCNs through carbonization and removal of silica. The DMCNs show a high carbon content, large mesopore volume of 1.484 cm
Publisher: The Chemical Society of Japan
Date: 05-05-2009
DOI: 10.1246/CL.2009.442
No related grants have been discovered for Jun Zhang.