ORCID Profile
0000-0001-9672-895X
Current Organisation
Université Laval
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Publisher: Hindawi Limited
Date: 2015
DOI: 10.1155/2015/869308
Publisher: American Chemical Society (ACS)
Date: 11-07-2008
DOI: 10.1021/LA8002788
Abstract: Fluoropolymer plasma coatings have been investigated for application as stent coatings due to their chemical stability, conformability, and hydrophobic properties. The challenge resides in the capacity for these coatings to remain adherent, stable, and cohesive after the in vivo stent expansion, which can generate local plastic deformation of up to 25%. Plasma-coated s les have been prepared by a multistep process on 316L stainless steel substrates, and some coated s les were plastically deformed to mimic a stent expansion. Analyses were then performed by X-ray photoelectron spectroscopy (XPS), X-ray photoelectron emission microscopy (X-PEEM), and time-of-flight secondary ion mass spectrometry (TOF-SIMS) to determine the chemical and physical effects of such a deformation on both the coating and the interfacial region. While XPS analyses always showed a continuous coating with no significant effect of the deformation, TOF-SIMS and near-edge X-ray absorption fine structure (derived from X-PEEM) data indicated the presence of a certain density of porosity and pinholes in all coatings as well as sparse fissures and molecular fragmentation in the deformed ones. The smallness of the area fraction affected by the defects and the subtlety of the chemical changes could only be evidenced through the higher chemical sensitivity of these latter techniques.
Publisher: Informa UK Limited
Date: 17-04-2023
Publisher: Elsevier BV
Date: 12-2011
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4NR02512A
Abstract: We describe a new method for the growth of reduced graphene oxide rGO on the 316L alloy of stainless steel 316L. Cell viability studies reveal that these rGO coatings do not have toxic effects on mammalian cells.
Publisher: Elsevier BV
Date: 04-2002
DOI: 10.1016/S0168-3659(02)00023-8
Abstract: Liposomes were immobilized onto the surface of perfluorinated polymer tape s les and tissue culture polystyrene well-plates using a multilayer immobilization strategy. In the first step, a thin interfacial bonding layer with surface aldehyde groups was deposited from a glow discharge struck in acetaldehyde vapour. Polyethylenimine was then covalently bound onto the aldehyde groups by reductive amination, followed by covalent binding of NHS-PEG-biotin molecules onto the surface amine groups by carbodiimide chemistry. Next, NeutrAvidin protein molecules were bound onto the PEG-biotin layer. Finally, liposomes containing PEG-biotinylated lipids were docked onto the remaining binding sites of the surface-immobilized NeutrAvidin molecules. AFM was used to image surface-bound liposomes and revealed a density well below close packing. The release characteristics of the surface-bound liposomes were measured by the fluorescence intensity changes of carboxyfluorescein upon release. Liposomes filled with sodium orthovanadate were surface immobilized and used in two in vitro angiogenesis assays. Marked differences compared to various control s les were observed, demonstrating the utility of drug-filled, surface-bound liposomes for evoking localized, controlled biological host responses proximal to an implanted biomedical device.
No related grants have been discovered for Diego Mantovani.