ORCID Profile
0000-0002-2062-8773
Current Organisations
Theorical Advances for Genomic Complexity (TAGC/Inserm U1090)
,
South China Agricultural University
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Publisher: Springer Science and Business Media LLC
Date: 12-2007
Abstract: Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (CM-R) and CM-susceptible (CM-S) mice, upon infection by Plasmodium berghei ANKA (PbA). We investigated mouse transcriptional responses at early and late stages of infection by use of cDNA microarrays. Through a rigorous statistical approach with multiple testing corrections, we showed that PbA significantly altered brain gene expression in CM-R (BALB/c), and in CM-S (CBA/J and C57BL/6) mice, and that 327 genes discriminated between early and late infection stages, between mouse strains, and between CM-R and CM-S mice. We further identified 104, 56, 84 genes with significant differential expression between CM-R and CM-S mice on days 2, 5, and 7 respectively. The analysis of their functional annotation indicates that genes involved in metabolic energy pathways, the inflammatory response, and the neuroprotection/neurotoxicity balance play a major role in cerebral malaria pathogenesis. In addition, our data suggest that cerebral malaria and Alzheimer's disease may share some common mechanisms of pathogenesis, as illustrated by the accumulation of β-amyloid proteins in brains of CM-S mice, but not of CM-R mice. Our microarray analysis highlighted marked changes in several molecular pathways in CM-S compared to CM-R mice, particularly at early stages of infection. This study revealed some promising areas for exploration that may both provide new insight into the knowledge of CM pathogenesis and the development of novel therapeutic strategies.
Publisher: American Chemical Society (ACS)
Date: 21-06-2003
DOI: 10.1021/JA035096M
Abstract: High-quality Zn(x)Cd(1-x)Se nanocrystals have been successfully prepared at high temperature by incorporating stoichiometric amounts of Zn and Se into pre-prepared CdSe nanocrystals. With increasing Zn content, a composition-tunable emission across most of the visible spectrum has been demonstrated by a systematic blue-shift in emission wavelength. The photoluminescence (PL) properties for the obtained Zn(x)Cd(1-x)Se nanocrystals (PL efficiency of 70-85%, fwhm = 22-30 nm) are comparable to those for the best reported CdSe-based QDs. In particular, they also have good PL properties in the blue spectral range. Moreover, the alloy nanocrystals can retain their high luminescence (PL efficiency of over 40%) when dispersed in aqueous solutions and maintain a symmetric peak shape and spectral position under rigorous experimental conditions. A rapid alloying process was observed at a temperature higher than "alloying point". The mechanism of the high luminescence efficiency and stability of Zn(x)Cd(1-x)Se nanocrystals is explored.
Publisher: Elsevier BV
Date: 2021
Publisher: Oxford University Press (OUP)
Date: 15-01-2006
DOI: 10.1086/498579
Abstract: The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R BALB/c and DBA/2) and CM-susceptible (CM-S C57BL/6 and CBA/J) mice by use of cDNA microarrays. By combining transcriptional profiling with rigorous statistical methods and cluster analysis, we identified a set of 69 genes that perfectly discriminated between mouse strains and between CM-R and CM-S mice. The analysis of gene ontological terms revealed that the genes that clustered and were related to susceptibility to CM preferentially belonged to some biological process classes, such as those pertaining to immune responses. Using a false discovery rate of 5% and the Welch t test, we identified 31 genes with consistent differential expression between CM-R and CM-S mice. These data indicate that microarray analysis may be useful for identification of candidate genes that are potentially responsible for resistance or susceptibility to mouse CM and suggest that candidate genes identified in mice could be specifically tested in humans for an association with disease severity.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 08-09-2023
Publisher: Springer Science and Business Media LLC
Date: 04-09-2018
Publisher: Public Library of Science (PLoS)
Date: 16-05-2011
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TA12915D
Abstract: FeNi intermetallic compound nanoparticles wrapped by N-doped graphitized carbon is used as a novel cocatalyst for boosting photocatalytic hydrogen evolution performance of g-C 3 N 4 .
Location: France
No related grants have been discovered for Xinhua Zhong.