Rosa Alati

Prenatal Tobacco Exposure and the Risk of Tobacco Smoking and Dependence in Offspring: a Systematic Review and Meta-Analysis

Publisher: Elsevier BV

Date: 10-2021

DOI: 10.1016/J.DRUGALCDEP.2021.108993

Risk of conduct and oppositional defiant disorder symptoms in offspring of parents with mental health problems: Findings from the Raine Study

Publisher: Elsevier BV

Date: 06-2021

DOI: 10.1016/J.JPSYCHIRES.2021.03.054

Maternal and paternal mental health problems and the risk of offspring depression in late adolescence: findings from the Raine study

Publisher: Informa UK Limited

Date: 02-2021

DOI: 10.1080/09638237.2021.1875423

Abstract: There are limited studies on the risk of depressive symptoms in adolescent offspring exposed to parental mental health problems in middle childhood. We investigated the association between parental mental health problems, particularly paternal emotional problems and maternal symptoms of anxiety and depression, and the risk of depressive symptoms in adolescent offspring aged 17. The study included 995 parent-offspring pairs from the 1989-91 birth cohort (the Raine Study) in Western Australia. Log-binomial regression was used to assess the associations. An increased risk of depression symptoms was observed in the adolescent offspring of mothers with depressive [RR 1.45, 95% CI 1.13-1.86] as well as anxiety symptoms [RR 1.43, 95% CI 1.09-1.87].Compared to those non-exposed, offspring whose mothers reported comorbid anxiety and depressive symptoms were more likely to have developed depressive symptoms by late adolescence [RR 1.63, 95%CI 1.11-2.38]. An increased risk of depressive symptoms was also seen in the offspring of fathers with emotional problems [RR 1.29, 95%CI 1.01-1.53]. Our findings suggest an increased risk of depressive symptoms in the adolescent offspring of parents with mental health problems, specifically paternal emotional problems (29%) and maternal anxiety (43%), depression (45%), as well as comorbid anxiety and depressive symptoms (63%).

Association between screening for antenatal depressive symptoms and delivery outcomes: The Born in Queensland Study.

Publisher: Wiley

Date: 21-04-2022

DOI: 10.1111/AJO.13534

Abstract: Evidence shows that depressive symptoms during pregnancy increase the risk of an intervention during delivery (induction, the use of forceps or vacuum, and caesarean sections (CS)). Many women with depression during pregnancy are not identified and therefore will not receive appropriate follow up of their symptoms. We hypothesised that routine screening for depressive symptoms during pregnancy could reduce detrimental consequences of depressive symptoms on delivery outcomes. We explored the association between screening for depressive symptoms during pregnancy and delivery outcomes. A cross-sectional analysis of state-wide administrative data sets. The population included all women who delivered a singleton in Queensland between the July and December of 2015. Logistic regression analyses were run in 27 501 women (93.1% of the total population) with information in all variables. The following were the main outcomes: onset of labour, CS, instrumental vaginal delivery, and all operative deliveries (including both CS and instrumental vaginal deliveries). Women who completed the screening had increased odds of a spontaneous onset of labour (adjusted odds ratio (aOR) 1.18 95% CI 1.09-1.27) and decreased odds of an operative delivery (instrumental or CS) (aOR 0.88 95% CI 0.81-0.96). Among women who had a vaginal delivery, those who completed the screening had decreased odds of having an instrumental delivery (aOR 0.84 95% CI 0.74-0.97). Sensitivity analyses in women who did not have a formal diagnosis of depression showed similar results. Our findings suggest that screening may decrease interventions during delivery in women with depressive symptoms.

The effect of prenatal cannabis exposure on offspring preterm birth: a cumulative meta-analysis

Publisher: Wiley

Date: 15-11-2023

DOI: 10.1111/ADD.16072

Abstract: Mixed results have been reported on the association between prenatal cannabis exposure and preterm birth. This study aimed to examine the magnitude and consistency of associations reported between prenatal cannabis exposure and preterm birth. This review was guided by the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines. We performed a comprehensive search of the literature on the following electronic databases: PubMed, EMBASE, SCOPUS, Psych‐INFO and Web of Science. The revised version of the Newcastle–Ottawa Scale (NOS) was used to appraise the methodological quality of the studies included in this review. Inverse variance weighted random‐effects cumulative meta‐analysis was undertaken to pool adjusted odds ratios (aOR) after sequential inclusion of each newly published study over time. The OR and 95% confidence interval (CI) limits required (stability threshold) for a new study to move the cumulative odds ratio to the null were also computed. A total of 27 observational studies published between 1986 and 2022 were included in the final cumulative meta‐analysis. The s le size of the studies ranged from 304 to 4.83 million births. Prenatal cannabis exposure was associated with an increased risk of preterm birth (pooled aOR = 1.35, 95% CI = 1.24–1.48). The stability threshold was 0.74 (95% CI limit = 0.81) by the end of 2022. Offspring exposed to maternal prenatal cannabis use was associated with higher risk of preterm birth, which warrants public health messages to avoid such exposure, particularly during pregnancy.

Discovery Projects - Grant ID: DP150104766

Start Date: 2015

End Date: 12-2018

Amount: $273,200.00

Funder: Australian Research Council

Discovery Projects - Grant ID: DP0988805

Start Date: 2009

End Date: 12-2013

Amount: $350,000.00

Funder: Australian Research Council

Discovery Projects - Grant ID: DP150100162

Start Date: 06-2015

End Date: 03-2018

Amount: $441,400.00

Funder: Australian Research Council