ORCID Profile
0000-0001-5234-1104
Current Organisation
University of Sheffield
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Publisher: Springer Science and Business Media LLC
Date: 25-10-2008
Publisher: IOP Publishing
Date: 08-2008
Publisher: American Chemical Society (ACS)
Date: 03-11-2021
DOI: 10.1021/ACS.BIOMAC.1C01129
Abstract: Highly porous emulsion templated polymers (PolyHIPEs) provide a number of potential advantages in the fabrication of scaffolds for tissue engineering and regenerative medicine. Porosity enables cell ingrowth and nutrient diffusion within, as well as waste removal from, the scaffold. The properties offered by emulsion templating alone include the provision of high interconnected porosity, and, in combination with additive manufacturing, the opportunity to introduce controlled multiscale porosity to complex or custom structures. However, the majority of monomer systems reported for PolyHIPE preparation are unsuitable for clinical applications as they are nondegradable. Thiol-ene chemistry is a promising route to produce biodegradable photocurable PolyHIPEs for the fabrication of scaffolds using conventional or additive manufacturing methods however, relatively little research has been reported on this approach. This study reports the groundwork to fabricate thiol- and polycaprolactone (PCL)-based PolyHIPE materials via a photoinitiated thiolene click reaction. Two different formulations, either three-arm PCL methacrylate (3PCLMA) or four-arm PCL methacrylate (4PCLMA) moieties, were used in the PolyHIPE formulation. Biocompatibility of the PolyHIPEs was investigated using human dermal fibroblasts (HDFs) and human osteosarcoma cell line (MG-63) by DNA quantification assay, and developed PolyHIPEs were shown to be capable of supporting cell attachment and viability.
Publisher: Wiley
Date: 24-05-2005
Publisher: ASMEDC
Date: 2007
Abstract: The objective of this work is to quantify nanomechanical and nanotribological properties of nano- and micro-particles filled polymer composites used for the dental restorative applications. Nanotribological performances of the two polymer composites with different reinforcing particulates were investigated using advanced microscopy techniques. Both the polymer composites composed of same dimethacrylate based monomeric mixture, Bisphenol-A-glycidyldimethacrylate (Bis-GMA), triethylene glycoldimethacrylate (TEGDMA), urethane dimethacrylate (UDMA), as matrix. It was found that the elastic modulus, hardness, particle size, shape, distribution and agglomeration significantly influence the friction and wear characteristics of the polymer composites. The results show that nanotribological performance of nanoparticle reinforced polymer composites is better than the microparticle reinforced polymer composites.
Location: United Kingdom of Great Britain and Northern Ireland
Location: Mexico
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Paul Hatton.