ORCID Profile
0000-0001-6787-9716
Current Organisation
University of Nottingham
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Publisher: Elsevier BV
Date: 06-3011
DOI: 10.1016/J.NEUROIMAGE.2011.02.019
Abstract: Previous studies have observed a sex-dependent lateralization of amygdala activation related to emotional memory. Specifically, it was shown that the activity of the right amygdala correlates significantly stronger with memory for images judged as arousing in men than in women, and that there is a significantly stronger relationship in women than in men between activity of the left amygdala and memory for arousing images. Using a large s le of 235 male adolescents and 235 females matched for age and handedness, we investigated the sex-specific lateralization of amygdala activation during an emotional face perception fMRI task. Performing a formal sex by hemisphere analysis, we observed in males a significantly stronger right amygdala activation as compared to females. Our results indicate that adolescents display a sex-dependent lateralization of amygdala activation that is also present in basic processes of emotional perception. This finding suggests a sex-dependent development of human emotion processing and may further implicate possible etiological pathways for mental disorders most frequent in adolescent males (i.e., conduct disorder).
Publisher: Springer Science and Business Media LLC
Date: 30-04-2013
DOI: 10.1038/MP.2013.44
Publisher: Wiley
Date: 17-03-2011
DOI: 10.1002/HBM.21261
Publisher: Oxford University Press (OUP)
Date: 06-12-2012
DOI: 10.1093/SCAN/NSS128
Publisher: Springer Science and Business Media LLC
Date: 02-07-2014
DOI: 10.1038/NATURE13402
Publisher: Springer Science and Business Media LLC
Date: 19-11-2010
DOI: 10.1038/MP.2010.4
Abstract: A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre genetic-neuroimaging study aimed at identifying the genetic and neurobiological basis of in idual variability in impulsivity, reinforcer sensitivity and emotional reactivity, and determining their predictive value for the development of frequent psychiatric disorders. Comprehensive behavioural and neuropsychological characterization, functional and structural neuroimaging and genome-wide association analyses of 2000 14-year-old adolescents are combined with functional genetics in animal and human models. Results will be validated in 1000 adolescents from the Canadian Saguenay Youth Study. The s le will be followed up longitudinally at the age of 16 years to investigate the predictive value of genetics and intermediate phenotypes for the development of frequent psychiatric disorders. This review describes the strategies the IMAGEN consortium used to meet the challenges posed by large-scale multicentre imaging-genomics investigations. We provide detailed methods and Standard Operating Procedures that we hope will be helpful for the design of future studies. These include standardization of the clinical, psychometric and neuroimaging-acquisition protocols, development of a central database for efficient analyses of large multimodal data sets and new analytic approaches to large-scale genetic neuroimaging analyses.
Publisher: Public Library of Science (PLoS)
Date: 14-08-2014
Publisher: Springer Science and Business Media LLC
Date: 09-04-2014
DOI: 10.1038/NPP.2014.83
Publisher: Public Library of Science (PLoS)
Date: 14-11-2013
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Claire Lawrence.