ORCID Profile
0000-0002-2668-4821
Current Organisations
ChemConnector
,
US Environmental Protection Agency
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Publisher: American Chemical Society (ACS)
Date: 05-05-2017
Publisher: Wiley
Date: 16-05-2018
DOI: 10.1002/MRC.4737
Publisher: Springer Science and Business Media LLC
Date: 17-06-2019
Publisher: Springer Science and Business Media LLC
Date: 21-10-2022
DOI: 10.1186/S12302-022-00680-6
Abstract: The NORMAN Association ( www.norman-network.com/ ) initiated the NORMAN Suspect List Exchange (NORMAN-SLE ds/SLE/ ) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water s les by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for “suspect screening” lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide. The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The in idual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community ( ommunities/norman-sle ), with a total of 40,000 unique views, 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem ( pubchem.ncbi.nlm.nih.gov/ ) and the US EPA’s CompTox Chemicals Dashboard ( ashboard/ ), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser ( lassification/#hid=101 ). The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the “one substance, one assessment” approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website ( ds/SLE/ ).
Publisher: F1000 Research Ltd
Date: 03-10-2023
Publisher: F1000 Research Ltd
Date: 08-11-2021
DOI: 10.12688/F1000RESEARCH.74502.1
Abstract: Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For ex le, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.
Publisher: Springer Science and Business Media LLC
Date: 30-08-2018
Publisher: Springer Science and Business Media LLC
Date: 26-06-2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9EM00068B
Abstract: A multi-disciplinary perspective on connecting chemistry, exposure and medical information to “neurotoxicity” for mass spectrometry-based environmental assessment, including multiple interactive resources for readers to use and explore.
Publisher: American Chemical Society (ACS)
Date: 12-08-2021
Publisher: Springer Science and Business Media LLC
Date: 12-2018
Publisher: Wiley
Date: 03-05-2011
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Antony Williams.