ORCID Profile
0000-0001-7087-1467
Current Organisation
Umeå University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 22-06-2016
Publisher: Springer Science and Business Media LLC
Date: 11-10-2011
Publisher: American Association for Cancer Research (AACR)
Date: 14-03-2011
DOI: 10.1158/0008-5472.CAN-10-2426
Abstract: Breast cancers with estrogen receptor α (ERα) expression are often more differentiated histologically than ERα-negative tumors, but the reasons for this difference are poorly understood. One possible explanation is that transcriptional cofactors associated with ERα determine the expression of genes which promote a more differentiated phenotype. In this study, we identify one such cofactor as coactivator-associated arginine methyltransferase 1 (CARM1), a unique coactivator of ERα that can simultaneously block cell proliferation and induce differentiation through global regulation of ERα-regulated genes. CARM1 was evidenced as an ERα coactivator in cell-based assays, gene expression microarrays, and mouse xenograft models. In human breast tumors, CARM1 expression positively correlated with ERα levels in ER-positive tumors but was inversely correlated with tumor grade. Our findings suggest that coexpression of CARM1 and ERα may provide a better biomarker of well-differentiated breast cancer. Furthermore, our findings define an important functional role of this histone arginine methyltransferase in reprogramming ERα-regulated cellular processes, implicating CARM1 as a putative epigenetic target in ER-positive breast cancers. Cancer Res 71(6) 2118–28. ©2011 AACR.
Publisher: Fennia - International Journal of Geography
Date: 24-01-2023
Abstract: Small villages in northern Sweden have seen a continuing removal of key services, such as schools, shops and public transport, since the 1970s. Disinvestment in public services has not been strategically planned but has happened in response to population loss and increased costs on a case-by-case basis. More recently, there has been a shift in policy thinking to what might be termed a ‘de-growth’ approach where digitalisation and increased personal mobility are used to provide new ways of delivering services. The purpose of this paper is to examine the existence of ‘resource deserts’ in Southern Lapland and the emergence (or consolidation) of village hierarchies in allocating public services. We map out the distribution of neighbourhood services (grocery stores, pre-/schools and petrol pumps) among villages, and explore the lived experiences in accessing these resources in different villages. Our results show that resource deserts clearly exist in the south and east of the region, while villages in the more sparsely populated western mountain areas were generally in a better position to retain resources. We identify a lack of consistent and transparent service planning at the village level as a key shortcoming in municipal and regional service strategies. There appear to be unofficial settlement hierarchies in the differential treatment of villages that are otherwise similar in population size, population change and distance to central places. We find that political decisions on service allocations are likely influenced by several factors. These include legacy effects relating to historic settlement status, the location of villages in relation to key transport or mobility corridors, as well as ideological factors favouring villages with more ‘exotic’ features and development potential in line with the municipalities’ economic, social and political priorities. We finally argue that a shift to de-growth needs to be more strategically planned if it is to eliminate resource deserts and promote equity of service access across all villages.
No related grants have been discovered for Anna-Karin Hurtig.