ORCID Profile
0000-0002-9131-056X
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Publisher: Elsevier BV
Date: 06-2018
DOI: 10.1016/J.PNEUROBIO.2018.01.002
Abstract: Parkinson's disease (PD) is a common neurodegenerative disease worldwide. While the typical motor symptoms of PD are well known, the lesser known non-motor symptoms can also greatly impact the patient's quality of life. These symptoms often appear before motor impairment, therefore identifying biomarkers that may predict PD risk or pathology has been a major and challenging endeavour. Given that the loss of dopamine, and its rate-limiting enzyme tyrosine hydroxylase (TH) occurs in PD, the expression and accompanying post-translational changes in TH during PD progression could yield insight into the disruption of cellular signalling occurring in the CNS, and also in peripheral tissues wherein catecholamine function plays a role. Furthermore, changes in expression and phosphorylation of TH in the brain and periphery can potentially reveal how TH stability and function are compromised in PD. As such, these changes can reveal how catecholamine synthesis capacity is gradually compromised and how changes in cellular signalling may govern the functional status of remaining catecholaminergic neurons. This review summarises the findings of clinical PD and neurotoxin models of PD that assessed TH expression or phosphorylation in catecholaminergic pathways in the brain and relevant peripheral tissues. We propose that establishing similar changes in TH expression and function in the CNS and periphery of established neurotoxin models can be a potential reference for comparison to changes in TH in human peripheral tissues. These changes in TH expression and phosphorylation may have predictive validity to estimate risk of PD progression before motor impairment is evident.
Publisher: Wiley
Date: 12-04-2019
DOI: 10.1111/RESP.13552
Abstract: Pulmonary arterial hypertension (PAH) is characterized by increased resistance in the distal pulmonary arteries, ultimately leading to right heart failure and, despite the available therapeutics, survival remains poor. Reduced expression of bone morphogenetic protein receptor type 2 (BMPR2) is strongly associated with PAH. Cell therapies are of interest in PAH, but whether this approach can upregulate BMPR2 is not known. Our objective was to evaluate a preclinical cell therapy approach based on upregulation of BMPR2. We assessed the therapeutic effect of intravenously injected BMPR2-augmented rat bone marrow-derived endothelial-like progenitor cells (BMPR2-BM-ELPC) on PAH in the rat monocrotaline (MCT) model. The cells accumulate in the lungs with negligible systemic distribution, but the vast majority are lost from the lungs by 24 h. Lungs from rats treated with BMPR2-BM-ELPC exhibited an immediate increase in BMPR2 and related intracellular signalling proteins. Treatment with BMPR2-BM-ELPC attenuated PAH as demonstrated by a reduction in right ventricular hypertrophy as well as right ventricular systolic and mean pulmonary arterial pressures. In addition, this treatment reversed PAH-induced vascular remodelling with a significant reduction in vessel thickness and muscularization. In view of the short retention time of injected cells in the lungs, the mechanism for the effects seen may be intracellular communication via exosomes. In support of this hypothesis, we demonstrate that BMPR2-transduced outgrowth endothelial progenitor cells (OECs) release BMPR2-expressing exosomes. BMPR2-augmented ELPC demonstrate therapeutic benefits in the rat model and may have clinical translation potential.
Publisher: AIP Publishing
Date: 13-02-1989
DOI: 10.1063/1.100902
Abstract: The lifetime of minority carriers in AlGaAs-GaAs quantum well structures grown by metalorganic chemical vapor deposition has been studied at room temperature and carrier densities up to 3×1016 cm−3 using time-resolved photoluminescence. Decay times are observed to be strongly dependent upon the quality of the AlGaAs barrier regions, excitation, and well width. Strong saturation of the decay times is observed with excitation indicating the presence of nonradiative traps. Saturated lifetimes as long as 650 ns have been measured in quantum wells with 200 Å well widths.
Publisher: Springer Science and Business Media LLC
Date: 1997
Publisher: SPIE
Date: 28-12-2006
DOI: 10.1117/12.641109
Publisher: SPIE
Date: 27-12-2007
DOI: 10.1117/12.713741
Publisher: SPIE
Date: 21-12-2008
DOI: 10.1117/12.786709
Publisher: SPIE
Date: 26-12-2008
DOI: 10.1117/12.823497
Publisher: Elsevier BV
Date: 07-2018
Publisher: SPIE
Date: 08-10-1999
DOI: 10.1117/12.368446
Publisher: SPIE
Date: 21-11-2001
DOI: 10.1117/12.449172
Publisher: Springer International Publishing
Date: 12-08-2016
Publisher: SPIE
Date: 21-12-2008
DOI: 10.1117/12.786709
Publisher: Springer Science and Business Media LLC
Date: 13-06-2009
Publisher: IEEE Comput. Soc. Press
Publisher: Wiley
Date: 15-08-2021
DOI: 10.1002/CBIN.11682
Abstract: Recently identified molecular targets in pulmonary artery hypertension (PAH) include sphingosine‐1‐phosphate (S1P) and zinc transporter ZIP12 signaling. This study sought to determine linkages between these pathways, and with BMPR2 signaling. Lung tissues from a rat model of monocrotaline‐induced PAH and therapeutic treatment with bone marrow–derived endothelial‐like progenitor cells transduced to overexpress BMPR2 were studied. Multifluorescence quantitative confocal microscopy (MQCM) was applied for analysis of protein expression and localization of markers of vascular remodeling ( α SMA and BMPR2), parameters of zinc homeostasis (zinc transporter SLC39A/ZIP family members 1, 10, 12 and 14 and metallothionein MT3) and S1P extracellular signaling (SPHK1, SPNS2, S1P receptor isoforms 1, 2, 3, 5) in 20–200 µm pulmonary microvessels. ZIP12 expression in whole lung tissue lysates was assessed by western blot. Spearman nonparametric correlations between MQCM readouts and hemodynamic parameters, Fulton index (FI), and right ventricular systolic pressure (RVSP) were measured. In line with PAH status, pulmonary microvessels in monocrotaline‐treated animals demonstrated significant ( p .05, n = 6 per group) upregulation of α SMA (twofold) and downregulation of BMPR2 (20%). Upregulated ZIP12 (92%), MT3 (57.7%), S1PR2 (54.8%), and S1PR3 (30.3%) were also observed. Significant positive and negative correlations were demonstrated between parameters of zinc homeostasis (ZIP12, MT3), S1P signaling (S1PRs, SPNS2), and vascular remodeling ( α SMA, FI, RVSP). MQCM and western blot analysis showed that monocrotaline‐induced ZIP12 upregulation could be partially negated by BMPR2‐targeted therapy. Our results indicate that altered zinc transport/storage and S1P signaling in the monocrotaline‐induced PAH rat model are linked to each other, and could be alleviated by BMPR2‐targeted therapy.
Publisher: AIP Publishing
Date: 27-04-1987
DOI: 10.1063/1.97904
Abstract: We report the study of growth conditions for achieving the sharp exciton resonances and low intensity saturation of these resonances in AlGaAs-GaAs multiple quantum well structures grown by metalorganic chemical vapor deposition. Low growth temperature is necessary to observe this sharp resonance feature at room temperature. The optimal growth conditions are a tradeoff between the high temperatures required for high quality AlGaAs and low temperatures required for high-purity GaAs. A strong optical saturation of the excitonic absorption has been observed. A saturation density as low as 250 W/cm2 is reported.
Publisher: SPIE
Date: 26-12-2008
DOI: 10.1117/12.814392
Publisher: IOP Publishing
Date: 04-2006
Publisher: SPIE
Date: 28-12-2006
DOI: 10.1117/12.639122
Publisher: SPIE-Intl Soc Optical Eng
Date: 08-09-2016
Publisher: SPIE
Date: 21-12-2008
DOI: 10.1117/12.767363
Publisher: Elsevier BV
Date: 12-2014
Publisher: SPIE
Date: 27-12-2007
DOI: 10.1117/12.713746
Publisher: IOP Publishing
Date: 04-2006
Publisher: SPIE
Date: 21-12-2007
DOI: 10.1117/12.765970
Publisher: MDPI AG
Date: 18-11-2014
DOI: 10.3390/S141121770
Publisher: IOP Publishing
Date: 12-1995
Publisher: SPIE
Date: 22-12-2015
DOI: 10.1117/12.2221917
Publisher: Wiley
Date: 21-10-2013
DOI: 10.1002/JBM.B.33063
Abstract: The management of chronic wounds has emerged as a major health care challenge during the 21st century consuming, significant portions of health care budgets. Chronic wounds such as diabetic foot ulcers, leg ulcers, and pressure sores have a significant negative impact on the quality of life of affected in iduals. Covering wounds with suitable dressings facilitates the healing process and is common practice in wound management plans. However, standard dressings do not provide insights into the status of the wound underneath. Parameters such as moisture, pressure, temperature and pH inside the dressings are indicative of the healing rate, infection, and wound healing phase. But owing to the lack of information available from within the dressings, these are often changed to inspect the wound, disturbing the normal healing process of wounds in addition to causing pain to the patient. Sensors embedded in the dressing would provide clinicians and nurses with important information that would aid in wound care decision making, improve patient comfort, and reduce the frequency of dressing changes. The potential benefits of this enabling technology would be seen in terms of a reduction in hospitalization time and health care cost. Modern sensing technology along with wireless radio frequency communication technology is poised to make significant advances in wound management. This review discusses issues related to the design and implementation of sensor technology and telemetry systems both incorporated in wound dressings to devise an automated wound monitoring technology, and also surveys the literature available on current sensor and wireless telemetry systems.
Publisher: IOP Publishing
Date: 10-1997
Publisher: IOP Publishing
Date: 10-1997
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-1988
DOI: 10.1109/3.7089
Publisher: SPIE
Date: 29-09-1999
DOI: 10.1117/12.364431
Publisher: Bentham Science Publishers Ltd.
Date: 12-2010
Publisher: IEEE
Date: 12-2011
Publisher: SPIE
Date: 27-12-2007
DOI: 10.1117/12.696230
Publisher: Elsevier BV
Date: 1988
Publisher: SPIE
Date: 14-11-1997
DOI: 10.1117/12.293549
Publisher: SPIE
Date: 16-04-1998
DOI: 10.1117/12.305549
Publisher: Springer Science and Business Media LLC
Date: 03-2015
Publisher: IEEE Comput. Soc. Press
Publisher: OMICS Publishing Group
Date: 2017
Publisher: SPIE
Date: 16-04-1998
DOI: 10.1117/12.305549
Publisher: AIP Publishing
Date: 09-11-1987
DOI: 10.1063/1.98625
Abstract: Atomic layer epitaxy (ALE) is a relatively new crystal growth technique which allows control of the growth process at the monolayer level through a self-limiting, surface-controlled growth mechanism. We report here the use of ALE to grow high-quality GaAs/AlGaAs quantum wells and the first successful demonstration of an injection laser with a quantum well active region grown by ALE. Room-temperature threshold current densities as low as 640 A/cm2 have been achieved in nonoptimized separate confinement structures.
Publisher: IEEE
Date: 02-2011
Publisher: SPIE
Date: 11-2002
DOI: 10.1117/12.472815
Publisher: SPIE
Date: 27-12-2006
DOI: 10.1117/12.713739
Start Date: 2006
End Date: 2009
Funder: Australian Research Council
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