ORCID Profile
0000-0003-2143-0416
Current Organisation
The Ohio State University
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Publisher: Wiley
Date: 03-2010
Publisher: American Veterinary Medical Association (AVMA)
Date: 02-2014
Abstract: Objective —To determine associations of blood analysis variables and orbit and nasal planum surface temperatures with the onset and severity of Mycoplasma bovis pneumonia in calves. Animals —28 healthy calves. Procedures —Calves were challenged with M bovis (n = 24) on day 0 or not challenged (4). Blood s les were obtained for cardiac troponin I, CBC, and serum biochemical analyses on various days. Orbit and nasal planum surface temperatures were determined with infrared thermography on various days. Calves were euthanized, gross necropsies were performed, heart and lung s les were collected for histologic evaluation, and microbial cultures of lung s les were performed on day 14. Pneumonia severity was categorized as mild ( 10% lung consolidation) or moderate (≥ 10% lung consolidation). Associations between measured variables and severity of pneumonia or s le collection day were determined. Results —Plasma cardiac troponin I concentration for the 28 calves was significantly higher on day 14 than it was on day 0 or 7 (least squares mean, 0.02, 0, and 0 ng/mL, respectively). No other variables changed significantly during the study. No substantial gross or histologic abnormalities were identified in cardiac muscle s les. Day 14 plasma fibrinogen concentration was significantly different between calves with mild pneumonia and those with moderate pneumonia (mean, 0.44 and 0.74 g/dL, respectively). Calves with moderate pneumonia had significantly lower least squares mean surface temperature of the dorsal aspect of the nasal planum (18.7°C) versus calves with mild pneumonia (22.9°C). Conclusions and Clinical Relevance —Results indicated the evaluated variables had low value for assessment of bovine respiratory disease complex in calves.
Publisher: American Veterinary Medical Association (AVMA)
Date: 06-2013
Abstract: Objective —To assess a commercially available point-of-care assay for measurement of bovine cardiac troponin I (cTnI) concentration in blood and plasma s les. S le —Prepared bovine plasma standard s les with known concentrations (0 to 1.0 ng/mL) of cTnI and blood and plasma s les obtained from 28 healthy 2.5-month-old Holstein calves. Procedures —Coefficients of variation were calculated for concentrations of cTnI in prepared standards determined with the point-of-care assay, and values were compared with the known concentrations. The cTnI concentrations in blood s les obtained from calves determined with the point-of-care assay were compared with cTnI concentrations in plasma s les obtained from those animals determined with a validated immunoassay. Results —The coefficients of variation of cTnI concentrations determined for prepared standards by use of the point-of-care assay were low ( 20%) for standards with cTnI concentrations ≥ 0.025 ng/mL. The blood cTnI concentrations determined with the point-of-care assay were not significantly different from the plasma cTnI concentrations determined with the validated immunoassay. Conclusions and Clinical Relevance —Results of this study indicated the point-of-care assay had high precision for determination of cTnI concentrations in most evaluated prepared bovine plasma standard s les. The point-of-care assay may be useful for determination of circulating concentrations of cTnI in cattle.
No related grants have been discovered for Jeffrey Lakritz.