ORCID Profile
0000-0002-4424-7094
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Bioinorganic chemistry | Nanoscale characterisation | Inorganic materials (incl. nanomaterials) | Carbon sequestration science | Nanomaterials | Inorganic chemistry | Nanotechnology | Macromolecular and materials chemistry | Functional materials | Solid state chemistry | Electrochemical energy storage and conversion
Publisher: American Chemical Society (ACS)
Date: 16-12-2022
Publisher: Wiley
Date: 10-06-2020
Publisher: Springer Science and Business Media LLC
Date: 21-08-2020
DOI: 10.1038/S41467-020-17782-5
Abstract: Hydrogen peroxide produced by electrochemical oxygen reduction reaction provides a potentially cost effective and energy efficient alternative to the industrial anthraquinone process. In this study, we demonstrate that by modulating the oxygen functional groups near the atomically dispersed cobalt sites with proper electrochemical/chemical treatments, a highly active and selective oxygen reduction process for hydrogen peroxide production can be obtained in acidic electrolyte, showing a negligible amount of onset overpotential and nearly 100% selectivity within a wide range of applied potentials. Combined spectroscopic results reveal that the exceptionally enhanced performance of hydrogen peroxide generation originates from the presence of epoxy groups near the Co–N 4 centers, which has resulted in the modification of the electronic structure of the cobalt atoms. Computational modeling demonstrates these electronically modified cobalt atoms will enhance the hydrogen peroxide productivity during oxygen reduction reaction in acid, providing insights into the design of electroactive materials for effective peroxide production.
Publisher: American Chemical Society (ACS)
Date: 15-03-2023
Publisher: American Chemical Society (ACS)
Date: 15-09-2022
Publisher: American Chemical Society (ACS)
Date: 05-02-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2TA08306J
Abstract: Relationship between d-metal active species (Co, Ni, & Cu) in Prussian blue analogue derived metal oxide/hydroxide films and the activation energy needed for full conversion of 5-HMF to 2,5-FDCA in alkaline solution.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TA02925H
Abstract: Atomically dispersed Co–Fe dual sites on nitrogen doped microporous carbon are constructed for ORR with superior performance, while XAS, differential PDF dPDF and DFT studies reveal the relationship between the catalytic performance and the local chemical environment.
Publisher: American Chemical Society (ACS)
Date: 23-10-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3YA00154G
Abstract: Selective uranium extraction from seawater by dopant engineered layered double hydroxide.
Publisher: International Union of Crystallography (IUCr)
Date: 26-05-2017
DOI: 10.1107/S1600577517006282
Abstract: The ability to generate new electrochemically active materials for energy generation and storage with improved properties will likely be derived from an understanding of atomic-scale structure/function relationships during electrochemical events. Here, the design and implementation of a new capillary electrochemical cell designed specifically for in situ high-energy X-ray diffraction measurements is described. By increasing the amount of electrochemically active material in the X-ray path while implementing low- Z cell materials with anisotropic scattering profiles, an order of magnitude enhancement in diffracted X-ray signal over traditional cell geometries for multiple electrochemically active materials is demonstrated. This signal improvement is crucial for high-energy X-ray diffraction measurements and subsequent Fourier transformation into atomic pair distribution functions for atomic-scale structural analysis. As an ex le, clear structural changes in LiCoO 2 under reductive and oxidative conditions using the capillary cell are demonstrated, which agree with prior studies. Accurate modeling of the LiCoO 2 diffraction data using reverse Monte Carlo simulations further verifies accurate background subtraction and strong signal from the electrochemically active material, enabled by the capillary working electrode geometry.
Publisher: Springer Science and Business Media LLC
Date: 30-11-2020
Publisher: American Chemical Society (ACS)
Date: 04-2020
Publisher: MDPI AG
Date: 27-08-2019
DOI: 10.3390/MA12172756
Abstract: The generation of structural defects in metal oxide catalysts offers a potential pathway to improve performance. Herein, we investigated the effect of thermal hydrogenation and low-temperature plasma treatments on mixed SiO2/TiO2 materials. Hydrogenation at 500 °C resulted in the reduction of the material to produce Ti3+ in the bulk TiO2. In contrast, low temperature plasma treatment for 10 or 20 min generated surface Ti3+ species via the removal of oxygen on both the neat and hydrogenated material. Assessing the photocatalytic activity of the materials demonstrated a 40–130% increase in the rate of formic acid oxidation after plasma treatment. A strong relationship between the Ti3+ content and catalyst activity was established, although a change in the Si–Ti interaction after plasma treating of the neat SiO2/TiO2 material was found to limit performance, and suggests that performance is not determined solely by the presence of Ti3+.
Publisher: Wiley
Date: 04-05-2020
Publisher: Elsevier BV
Date: 08-2018
DOI: 10.1016/J.XPHS.2018.03.029
Abstract: Pharmaceutical compounds with poor solubility are loaded within mesoporous materials to understand the effect of mesoscale confinement on their dissolution behavior. Structural and calorimetric characterization is combined with atomic pair distribution function analysis probing the interactions between the silica surface and the loaded amorphous compound. While different degrees of amorphism are not identifiable from X-ray diffraction data or calorimetric techniques, the atomic pair distribution function analysis can help identify local ordering of the drug molecules. Together with a list of drug descriptors such as crystallization properties, molecular size, and glass transition temperature, the behavior of encapsulated compounds and their release kinetics may be rationalized. Dissolution experiments confirm that different release rates can be achieved with small differences in mesopore design, such as the presence of micropores in Santa Barbara Amorphous-15 and loading amount.
Publisher: Wiley
Date: 28-02-2020
Publisher: American Chemical Society (ACS)
Date: 07-04-2022
Publisher: Wiley
Date: 12-10-2023
Publisher: Springer Science and Business Media LLC
Date: 12-2020
DOI: 10.1557/MRS.2020.299
Publisher: Wiley
Date: 04-12-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0NR07068H
Abstract: Elucidating the location of stabilized nanoclusters within their protein hosts is an existing challenge towards the optimized development of functional protein-nanoclusters.
Publisher: American Chemical Society (ACS)
Date: 20-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CY01293A
Abstract: Atomic-sized lanthanum doping via double flame spray pyrolysis leads to remarkable dry reforming of methane performance.
Publisher: American Chemical Society (ACS)
Date: 24-03-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1GC01208H
Abstract: Unsaturated Co metal sites in CoFe Prussian blue analogues are introduced by pulse electrodeposition on Ni foam. The PBA electrode achieved 94% yield of 2,5-furandicarboxylic acid from 5-hydroxymethylfurfural at 1.43 V vs . RHE.
Publisher: American Chemical Society (ACS)
Date: 17-12-2015
DOI: 10.1021/JACS.5B09529
Abstract: Peptide-enabled nanoparticle (NP) synthesis routes can create and/or assemble functional nanomaterials under environmentally friendly conditions, with properties dictated by complex interactions at the biotic/abiotic interface. Manipulation of this interface through sequence modification can provide the capability for material properties to be tailored to create enhanced materials for energy, catalysis, and sensing applications. Fully realizing the potential of these materials requires a comprehensive understanding of sequence-dependent structure/function relationships that is presently lacking. In this work, the atomic-scale structures of a series of peptide-capped Au NPs are determined using a combination of atomic pair distribution function analysis of high-energy X-ray diffraction data and advanced molecular dynamics (MD) simulations. The Au NPs produced with different peptide sequences exhibit varying degrees of catalytic activity for the exemplar reaction 4-nitrophenol reduction. The experimentally derived atomic-scale NP configurations reveal sequence-dependent differences in structural order at the NP surface. Replica exchange with solute-tempering MD simulations are then used to predict the morphology of the peptide overlayer on these Au NPs and identify factors determining the structure/catalytic properties relationship. We show that the amount of exposed Au surface, the underlying surface structural disorder, and the interaction strength of the peptide with the Au surface all influence catalytic performance. A simplified computational prediction of catalytic performance is developed that can potentially serve as a screening tool for future studies. Our approach provides a platform for broadening the analysis of catalytic peptide-enabled metallic NP systems, potentially allowing for the development of rational design rules for property enhancement.
Publisher: American Chemical Society (ACS)
Date: 13-09-2016
Abstract: Bimetallic nanoparticles are of immense scientific and technological interest given the synergistic properties observed when two different metallic species are mixed at the nanoscale. This is particularly prevalent in catalysis, where bimetallic nanoparticles often exhibit improved catalytic activity and durability over their monometallic counterparts. Yet despite intense research efforts, little is understood regarding how to optimize bimetallic surface composition and structure synthetically using rational design principles. Recently, it has been demonstrated that peptide-enabled routes for nanoparticle synthesis result in materials with sequence-dependent catalytic properties, providing an opportunity for rational design through sequence manipulation. In this study, bimetallic PdAu nanoparticles are synthesized with a small set of peptides containing known Pd and Au binding motifs. The resulting nanoparticles were extensively characterized using high-resolution scanning transmission electron microscopy, X-ray absorption spectroscopy, and high-energy X-ray diffraction coupled to atomic pair distribution function analysis. Structural information obtained from synchrotron radiation methods was then used to generate model nanoparticle configurations using reverse Monte Carlo simulations, which illustrate sequence dependence in both surface structure and surface composition. Replica exchange with solute tempering molecular dynamics simulations were also used to predict the modes of peptide binding on monometallic surfaces, indicating that different sequences bind to the metal interfaces via different mechanisms. As a testbed reaction, electrocatalytic methanol oxidation experiments were performed, wherein differences in catalytic activity are clearly observed in materials with identical bimetallic composition. Taken together, this study indicates that peptides could be used to arrive at bimetallic surfaces with enhanced catalytic properties, which could be leveraged for rational bimetallic nanoparticle design using peptide-enabled approaches.
Publisher: Wiley
Date: 07-07-2023
DOI: 10.1002/CNCY.22741
Abstract: After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address the need for reproducibility and standardization in lymph node cytopathology. Since then, the risk of malignancy for the categories of the Sydney system has been explored by several studies, but no studies have yet examined the interobserver reproducibility of the Sydney system. The authors assessed interobserver reproducibility of the Sydney system on 85 lymph node fine‐needle aspiration cytology cases reviewed by 15 cytopathologists from 12 institutions in eight different countries, resulting in 1275 diagnoses. In total, 186 slides stained with Diff‐Quik, Papanicolaou, and immunocytochemistry were scanned. A subset of the cases included clinical data and results from ultrasound examinations, flow cytometry immunophenotyping, and fluorescence in situ hybridization analysis. The study participants assessed the cases digitally using whole‐slide images. Overall, the authors observed an almost perfect agreement of cytopathologists with the ground truth (median weighted Cohen κ = 0.887 interquartile range, κ = 0.210) and moderate overall interobserver concordance (Fleiss κ = 0.476). There was substantial agreement for the inadequate and malignant categories (κ = 0.794 and κ = 0.729, respectively), moderate agreement for the benign category (κ = 0.490), and very slight agreement for the s uspicious (κ = 0.104) and atypical (κ = 0.075) categories. The Sydney system for reporting lymph node cytopathology shows adequate interobserver concordance. Digital microscopy is an adequate means to assess lymph node cytopathology specimens.
Publisher: IOP Publishing
Date: 06-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NR00371A
Abstract: The protein corona of nanoparticles is becoming a tool to understand the relation between intrinsic physicochemical properties and extrinsic biological behaviour.
Publisher: American Chemical Society (ACS)
Date: 28-01-2020
DOI: 10.1021/JACS.9B13313
Abstract: Controlling which facets are exposed in nanocrystals is crucial to understanding different activity between ordered and disordered alloy electrocatalysts. We modify the degree of ordering of Pt
Publisher: Wiley
Date: 16-08-2019
Publisher: Wiley
Date: 24-06-2019
Publisher: American Chemical Society (ACS)
Date: 12-07-2021
Publisher: Wiley
Date: 04-07-2019
Publisher: American Chemical Society (ACS)
Date: 12-02-2019
Publisher: American Chemical Society (ACS)
Date: 24-08-2023
No related organisations have been discovered for Nicholas Bedford.
Start Date: 03-2023
End Date: 03-2026
Amount: $441,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2023
End Date: 07-2024
Amount: $549,859.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2024
End Date: 02-2031
Amount: $35,000,000.00
Funder: Australian Research Council
View Funded Activity