ORCID Profile
0000-0002-0513-6797
Current Organisations
KU Leuven
,
Ocean University of China
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Publisher: Elsevier BV
Date: 2013
DOI: 10.1016/J.NEURON.2012.11.009
Abstract: GABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the embryonic ventral telencephalon (VT) and migrate tangentially to the cortex, guided by membrane-bound and secreted factors. We found that Sip1 (Zfhx1b, Zeb2), a transcription factor enriched in migrating cortical interneurons, is required for their proper differentiation and correct guidance. The majority of Sip1 knockout interneurons fail to migrate to the neocortex and stall in the VT. RNA sequencing reveals that Sip1 knockout interneurons do not acquire a fully mature cortical interneuron identity and contain increased levels of the repulsive receptor Unc5b. Focal electroporation of Unc5b-encoding vectors in the MGE of wild-type brain slices disturbs migration to the neocortex, whereas reducing Unc5b levels in Sip1 knockout slices and brains rescues the migration defect. Our results reveal that Sip1, through tuning of Unc5b levels, is essential for cortical interneuron guidance.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3TA13593D
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CY00082D
Abstract: We reported a facile approach to fabricate Cu 2 O/TiO 2 /rGO heterojunction membranes with superior photocatalytic efficiency and significantly improved photocorrosion resistance.
Publisher: Oxford University Press (OUP)
Date: 27-06-2023
DOI: 10.1093/ICB/ICAD087
Abstract: Few animal groups can claim the level of wonder that cephalopods instill in the minds of researchers and the general public. Much of cephalopod biology, however, remains unexplored: the largest invertebrate brain, difficult husbandry conditions, and complex (meta-)genomes, among many other things, have hindered progress in addressing key questions. However, recent technological advancements in sequencing, imaging, and genetic manipulation have opened new avenues for exploring the biology of these extraordinary animals. The cephalopod molecular biology community is thus experiencing a large influx of researchers, emerging from different fields, accelerating the pace of research in this clade. In the first post-pandemic event at the Cephalopod International Advisory Council (CIAC) conference in April 2022, over 40 participants from all over the world met and discussed key challenges and perspectives for current cephalopod molecular biology and evolution. Our particular focus was on the fields of comparative and regulatory genomics, gene manipulation, single-cell transcriptomics, metagenomics, and microbial interactions. This article is a result of this joint effort, summarizing the latest insights from these emerging fields, their bottlenecks, and potential solutions. The article highlights the interdisciplinary nature of the cephalopod-omics community and provides an emphasis on continuous consolidation of efforts and collaboration in this rapidly evolving field.
Publisher: Springer Science and Business Media LLC
Date: 30-10-2020
Publisher: Elsevier BV
Date: 2015
DOI: 10.1016/J.JCIS.2014.09.013
Abstract: Surface functional groups on carbon dots (CDs) play a critical role in defining their photoluminescence properties and functionalities. A new kind of organosilane-functionalized CDs (OS-CDs) were formed by a low temperature (150°C) solvothermal synthesis of citric acid in N-(β-aminoethyl)-γ-aminopropylmethyl-dimethoxysilane (AEAPMS). Uniquely, the as-synthesized OS-CDs have dual long chain functional groups with both NH2 and Si(OCH3)3 as terminal moieties. Double sided anchoring of AEAPMS on CDs occurs, facilitated by the water produced (and confined at the interface between CDs and solvent) when citric acid condenses into the carbon core. The resultant OS-CDs are multi-solvent dispersible, and more significantly, they exhibit excellent selectivity and sensitivity to Hg(2+) with a linear detection range of 0-50 nM and detection limit of 1.35 nM. The sensitivity and selectivity to Hg(2+) is preserved in highly complex fluids with a detection limit of 1.7 nM in spiked 1 M NaCl solution and a detection limit of 50 nM in municipal wastewater effluent. The results show that the OS-CDs synthesised by the solvothermal method in AEAPMS may be used as an effective Hg(2+) sensor in practical situations.
Publisher: American Chemical Society (ACS)
Date: 25-04-2012
DOI: 10.1021/JE3001552
Publisher: Springer Science and Business Media LLC
Date: 09-02-2012
Publisher: Elsevier BV
Date: 03-2017
Publisher: Elsevier BV
Date: 07-2012
Publisher: Elsevier BV
Date: 10-2017
Publisher: Trans Tech Publications, Ltd.
Date: 07-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.557-559.739
Abstract: In this work, high quantum yield nanodots were produced by using an organosilane as a coordinating solvent and fabricated the product into solid films. In order to assess the practicality as a material for optoelectronic device, solid state properties were analyzed extensively including UV stability and thermal stability.
Publisher: Rockefeller University Press
Date: 26-10-2015
DOI: 10.1084/JEM.20150809
Abstract: Natural killer (NK) cell maturation is a tightly controlled process that endows NK cells with functional competence and the capacity to recognize target cells. Here, we found that the transcription factor (TF) Zeb2 was the most highly induced TF during NK cell maturation. Zeb2 is known to control epithelial to mesenchymal transition, but its role in immune cells is mostly undefined. Targeted deletion of Zeb2 resulted in impaired NK cell maturation, survival, and exit from the bone marrow. NK cell function was preserved, but mice lacking Zeb2 in NK cells were more susceptible to B16 melanoma lung metastases. Reciprocally, ectopic expression of Zeb2 resulted in a higher frequency of mature NK cells in all organs. Moreover, the immature phenotype of Zeb2−/− NK cells closely resembled that of Tbx21−/− NK cells. This was caused by both a dependence of Zeb2 expression on T-bet and a probable cooperation of these factors in gene regulation. Transgenic expression of Zeb2 in Tbx21−/− NK cells partially restored a normal maturation, establishing that timely induction of Zeb2 by T-bet is an essential event during NK cell differentiation. Finally, this novel transcriptional cascade could also operate in human as T-bet and Zeb2 are similarly regulated in mouse and human NK cells.
Publisher: Royal Society of Chemistry (RSC)
Date: 03-09-2014
DOI: 10.1039/C4CC05295A
Abstract: In this communication, we fabricated graphene oxide membranes with tunable permeation by embedding carbon nanodots of controllable sizes.
Publisher: American Society of Hematology
Date: 26-05-2011
DOI: 10.1182/BLOOD-2010-08-300236
Abstract: Zeb2 (Sip1/Zfhx1b) is a member of the zinc-finger E-box–binding (ZEB) family of transcriptional repressors previously demonstrated to regulate epithelial-to-mesenchymal transition (EMT) processes during embryogenesis and tumor progression. We found high Zeb2 mRNA expression levels in HSCs and hematopoietic progenitor cells (HPCs), and examined Zeb2 function in hematopoiesis through a conditional deletion approach using the Tie2-Cre and Vav-iCre recombination mouse lines. Detailed cellular analysis demonstrated that Zeb2 is dispensable for hematopoietic cluster and HSC formation in the aorta-gonadomesonephros region of the embryo, but is essential for normal HSC/HPC differentiation. In addition, Zeb2-deficient HSCs/HPCs fail to properly colonize the fetal liver and/or bone marrow and show enhanced adhesive properties associated with increased β1 integrin and Cxcr4 expression. Moreover, deletion of Zeb2 resulted in embryonic (Tie2-Cre) and perinatal (Vav-icre) lethality due to severe cephalic hemorrhaging and decreased levels of angiopoietin-1 and, subsequently, improper pericyte coverage of the cephalic vasculature. These results reveal essential roles for Zeb2 in embryonic hematopoiesis and are suggestive of a role for Zeb2 in hematopoietic-related pathologies in the adult.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2JM30935A
Publisher: Elsevier BV
Date: 05-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0RA07153F
Abstract: The addition of surfactants can promote the formation of mesopores and improve the dispersion of MoS 2 slabs.
Publisher: Rockefeller University Press
Date: 26-10-2015
DOI: 10.1084/JEM.20150194
Abstract: ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition–dependent tumor metastasis. Although the function of ZEB2 in T lymphocytes is unknown, activity of the closely related family member ZEB1 has been implicated in lymphocyte development. Here, we find that ZEB2 expression is up-regulated by activated T cells, specifically in the KLRG1hi effector CD8+ T cell subset. Loss of ZEB2 expression results in a significant loss of antigen-specific CD8+ T cells after primary and secondary infection with a severe impairment in the generation of the KLRG1hi effector memory cell population. We show that ZEB2, which can bind DNA at tandem, consensus E-box sites, regulates gene expression of several E-protein targets and may directly repress Il7r and Il2 in CD8+ T cells responding to infection. Furthermore, we find that T-bet binds to highly conserved T-box sites in the Zeb2 gene and that T-bet and ZEB2 regulate similar gene expression programs in effector T cells, suggesting that T-bet acts upstream and through regulation of ZEB2. Collectively, we place ZEB2 in a larger transcriptional network that is responsible for the balance between terminal differentiation and formation of memory CD8+ T cells.
Publisher: Springer Science and Business Media LLC
Date: 27-03-2019
No related grants have been discovered for Wentai Wang.