ORCID Profile
0000-0002-5149-1781
Current Organisations
Murdoch Children's Research Institute
,
Murdoch Childrens Research Institute
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Publisher: Elsevier BV
Date: 10-2020
Publisher: American Society of Neuroradiology (ASNR)
Date: 19-12-2020
DOI: 10.3174/AJNR.A6369
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 03-2022
DOI: 10.1212/WNL.0000000000013250
Abstract: To investigate brain regional white matter development in full-term (FT) and very preterm (VP) children at term equivalent and 7 and 13 years of age based on the ratio of T 1 - and T 2 -weighted MRI ( T 1 -w/ T 2 -w), including (1) whether longitudinal changes differ between birth groups or sexes, (2) associations with perinatal risk factors in VP children, and (3) relationships with neurodevelopmental outcomes at 13 years. Prospective longitudinal cohort study of VP (born weeks' gestation or ,250 g) and FT infants born between 2001 and 2004 and followed up at term equivalent and 7 and 13 years of age, including MRI studies and neurodevelopmental assessments. T 1 -w/ T 2 -w images were parcellated into 48 white matter regions of interest. Of 224 VP participants and 76 FT participants, 197 VP and 55 FT participants had useable T 1 -w/ T 2 -w data from at least one timepoint. T 1 -w/ T 2 -w values increased between term equivalent and 13 years of age, with little evidence that longitudinal changes varied between birth groups or sexes. VP birth, neonatal brain abnormalities, being small for gestational age, and postnatal infection were associated with reduced regional T 1 -w/ T 2 -w values in childhood and adolescence. Increased T 1 -w/ T 2 -w values across the white matter at 13 years were associated with better motor and working memory function for all children. Within the FT group only, larger increases in T 1 -w/ T 2 -w values from term equivalent to 7 years were associated with poorer attention and executive function, and higher T 1 -w/ T 2 -w values at 7 years were associated with poorer mathematics performance. VP birth and multiple known perinatal risk factors are associated with long-term reductions in the T 1 -w/ T 2 -w ratio in white matter regions in childhood and adolescence, which may relate to alterations in microstructure and myelin content. Increased T 1 -w/ T 2 -w ratio at 13 years appeared to be associated with better motor and working memory function and there appeared to be developmental differences between VP and FT children in the associations for attention, executive functioning, and mathematics performance.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 17-08-2023
DOI: 10.1212/WNL.0000000000207705
Abstract: Research investigating neonatal arterial ischemic stroke (NAIS) outcomes have shown that combined cortical and basal ganglia infarction or involvement of the corticospinal tract predict cerebral palsy (CP). The research question was whether voxel-based lesion-symptom mapping (VLSM) on acute MRI can identify brain regions associated with CP and neurodevelopmental impairments in neonatal arterial ischemic stroke (NAIS). Newborns were recruited from prospective Australian and Swiss pediatric stroke registries. CP diagnosis was based on clinical examination. Language and cognitive-behavioral impairments were assessed using the Pediatric Stroke Outcome Measure, dichotomized to good (0-0.5) or poor (≥ 1), at ≥18 months of age. Infarcts were manually segmented using diffusion-weighted imaging, registered to a neonatal-specific brain template. VLSM was conducted using MATLAB SPM12 toolbox. A general linear model was used to correlate lesion masks with motor, language and cognitive-behavioral outcomes. Voxel-wise t- test statistics were calculated, correcting for multiple comparisons using family-wise error rate (FWE). Eighty-five newborns met inclusion criteria. Infarct lateralization was left hemisphere (62%), right (8%) and bilateral (30%). At median age 2.1 years (IQR 1.9-2.6), 33% developed CP and 42% had neurological impairments. 54 grey and white matter regions correlated with CP (t .33 FWE .05), including primary motor pathway regions, such as the precentral gyrus, and cerebral peduncle, and regions functionally connected to the primary motor pathway, such as the pallidum, and corpus callosum motor segment. No significant correlations were found for language or cognitive-behavioral outcomes. CP following NAIS correlates with infarct regions directly involved in motor control and , or in functionally connected regions. Areas associated with language or cognitive-behavioral impairment are less clear.
Publisher: Elsevier BV
Date: 07-2016
DOI: 10.1016/J.JPEDS.2016.04.002
Abstract: To explore the association between brain maturation, injury, and volumes at term-equivalent age with 2-year development in moderate and late preterm children. Moderate and late preterm infants were recruited at birth and assessed at age 2 years using the Bayley Scales of Infant and Toddler Development, Third Edition. Brain magnetic resonance imaging (MRI) was performed at term-equivalent age and qualitatively assessed for brain maturation (myelination of the posterior limb of the internal capsule and gyral folding) and injury. Brain volumes were measured using advanced segmentation techniques. The associations between brain MRI measures with developmental outcomes were explored using linear regression analyses. A total of 197 children underwent MRI and assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. Larger total brain tissue volumes were associated with higher cognitive and language scores (adjusted coefficients per 10% increase in brain size 95% CI of 3.2 [0.4, 5.6] and 5.6 [2.4, 8.8], respectively). Similar relationships were documented for white matter volumes with cognitive and language scores, multiple cerebral structures with language scores, and cerebellar volumes with motor scores. Larger cerebellar volumes were independently associated with better language and motor scores, after adjustment for other perinatal factors. There was little evidence of relationships between myelination of the posterior limb of the internal capsule, gyral folding, or injury with 2-year development. Larger total brain tissue, white matter, and cerebellar volumes at term-equivalent age are associated with better neurodevelopment in moderate and late preterm children. Brain volumes may be an important marker for neurodevelopmental deficits described in moderate and late preterm children.
No related grants have been discovered for Jian Chen.