ORCID Profile
0000-0002-3708-2965
Current Organisations
Texas Chiropractic College
,
James Cook University
,
University of Sydney
,
University of California Davis
,
Harvard Medical School
,
University of Oxford
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Related Links
Publications
Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis
Publisher: Oxford University Press (OUP)
Date: 03-10-2008
DOI: 10.1093/RHEUMATOLOGY/KEN376
Abstract: The heritability of RA has been estimated to be approximately 55%, of which the MHC contributes about one-third. HLA-DRB1 alleles are strongly associated with RA, but it is likely that significant non-DRB1 MHC genetic susceptibility factors are involved. Previously, we identified two three-marker haplotypes in a 106-kb region in the MHC class III region immediately centromeric to TNF, which are strongly associated with RA on HLA-DRB1*0404 haplotypes. In the present study, we aimed to refine these associations further using a combination of genotyping and gene expression studies. Thirty-nine nucleotide polymorphisms (SNPs) were genotyped in 95 DRB1*0404 carrying unrelated RA cases, 125 DRB1*0404-carrying healthy controls and 87 parent-case trio RA families in which the affected child carried HLA-DRB1*04. Quantitative RT-PCR was used to assess the expression of the positional candidate MHC class III genes APOM, BAT2, BAT3, BAT4, BAT5, AIF1, C6orf47, CSNK2beta and LY6G5C, and the housekeeper genes, hypoxanthine-guanine phosphoribosyltransferase (HPRT) and beta(2)-microglobulin (B2M) in 31 RA cases and 21 ethnically, age- and sex-matched healthy controls. Synovial membrane specimens from RA, PsA and OA cases were stained by an indirect immunoperoxidase technique using a mouse-anti-human AIF1 monoclonal antibody. Association was observed between RA and single markers or two marker haplotypes involving AIF1, BAT3 and CSNK. AIF1 was also significantly overexpressed in RA mononuclear cells (1.5- to 1.9-fold difference, P = 0.02 vs HPRT, P = 0.002 vs B2M). AIF1 protein was clearly expressed by synovial macrophages in all the inflammatory synovial s les in contrast to the non-inflammatory OA s les. The results of the genotyping and expression studies presented here suggest a role for AIF1 in both the aetiology and pathogenesis of RA.
Convergent validity and reliability of a novel repeated agility protocol in junior rugby league players
Publisher: F1000 Research Ltd
Date: 17-06-2020
DOI: 10.12688/F1000RESEARCH.23129.1
Abstract: Background: Rugby league involves repeated, complex, change-of-direction movements, although there are no test protocols that specifically assesses these physical fitness profiles. Thus, the current study examined the convergent validity and reliability of a repeated Illinois Agility (RIA) protocol in adolescent Rugby League players. Methods: Twenty-two junior Rugby League players completed 4 sessions with each separated by 7 days. Initially, physical fitness characteristics at baseline (i.e., multi-stage fitness, countermovement jump, 30-m sprint, single-effort agility and repeated sprint ability [RSA]) were assessed. The second session involved a familiarisation of RIA and repeated T-agility test (RTT) protocols. During the third and fourth sessions, participants completed the RIA and RTT protocols in a randomised, counterbalanced design to examine the validity and test-retest reliability of these protocols. Results: For convergent validity, significant correlations were identified between RIA and RTT performances (r= .80 p .05). For contributors to RIA performance, significant correlations were identified between all baseline fitness characteristics and RIA (r = .71 p 0.05). Reliability of the RIA protocol was near perfect with excellent intra-class correlation coefficient (0.87-0.97), good ratio limits of agreement (×/÷ 1.05-1.06) and low coefficient of variations (1.77-1.97%). Conclusions: The current study has demonstrated the RIA to be a simple, valid and reliable field test that can provide coaches with information about their athlete’s ability to sustain high intensity, multi-directional running efforts.
Convergent validity and reliability of a novel repeated agility protocol in junior rugby league players
Publisher: F1000 Research Ltd
Date: 08-10-2021
DOI: 10.12688/F1000RESEARCH.23129.2
Abstract: Background: : Rugby league involves repeated, complex, and high intensity change-of-direction (COD) movements with no existing test protocols that specifically assesses these multiple physical fitness components simultaneously. Thus, the current study examined the convergent validity of a repeated Illinois Agility (RIA) protocol with the repeated T-agility protocol, and the repeatability of the RIA protocol in adolescent Rugby League players. Furthermore, aerobic capacity and anaerobic and COD performance were assessed to determine whether these physical qualities were important contributors to the RIA protocol. Methods: Twenty-two junior Rugby League players completed 4 sessions with each separated by 7 days. Initially, physical fitness characteristics at baseline (i.e., Beep test,, countermovement jump, 30-m sprint, single-effort COD and repeated sprint ability [RSA]) were assessed. The second session involved a familiarisation of RIA and repeated T-agility test (RTT) protocols. During the third and fourth sessions, participants completed the RIA and RTT protocols in a randomised, counterbalanced design to examine the validity and test-retest reliability of these protocols. Results: For convergent validity, significant correlations were identified between RIA and RTT performances (r= .80 p .05). For contributors to RIA performance, significant correlations were identified between all baseline fitness characteristics and RIA (r = .71 p 0.05). Reliability of the RIA protocol was near perfect with excellent intra-class correlation coefficient (0.87-0.97), good ratio limits of agreement (×/÷ 1.05-1.06) and low coefficient of variations (1.8-2.0%). Conclusions: The current study has demonstrated the RIA to be a simple, valid and reliable field test for RL athletes that can provide coaches with information about their team’s ability to sustain high intensity, multi-directional running efforts.
Convergent validity and reliability of a novel repeated agility protocol in junior rugby league players
Publisher: F1000 Research Ltd
Date: 22-11-2021
DOI: 10.12688/F1000RESEARCH.23129.3
Abstract: Background: : Rugby league involves repeated, complex, and high intensity change-of-direction (COD) movements with no existing test protocols that specifically assesses these multiple physical fitness components simultaneously. Thus, the current study examined the convergent validity of a repeated Illinois Agility (RIA) protocol with the repeated T-agility protocol, and the repeatability of the RIA protocol in adolescent Rugby League players. Furthermore, aerobic capacity and anaerobic and COD performance were assessed to determine whether these physical qualities were important contributors to the RIA protocol. Methods: Twenty-two junior Rugby League players completed 4 sessions with each separated by 7 days. Initially, physical fitness characteristics at baseline (i.e., Multi-stage Shuttle test, countermovement jump, 30-m sprint, single-effort COD and repeated sprint ability [RSA]) were assessed. The second session involved a familiarisation of RIA and repeated T-agility test (RTT) protocols. During the third and fourth sessions, participants completed the RIA and RTT protocols in a randomised, counterbalanced design to examine the validity and test-retest reliability of these protocols. Results: For convergent validity, significant correlations were identified between RIA and RTT performances (r= .80 p .05). For contributors to RIA performance, significant correlations were identified between all baseline fitness characteristics and RIA (r = .71 p 0.05). Reliability of the RIA protocol was near perfect with excellent intra-class correlation coefficient (0.87-0.97), good ratio limits of agreement (×/÷ 1.05-1.06) and low coefficient of variations (1.8-2.0%). Conclusions: The current study has demonstrated the RIA to be a simple, valid and reliable field test for RL athletes that can provide coaches with information about their team’s ability to sustain high intensity, multi-directional running efforts.
Related Organisations
University Of Oxford
Location: United Kingdom of Great Britain and Northern Ireland
Related Funding Activities
No related grants have been discovered for Iannis Adamopoulos.