ORCID Profile
0000-0001-9983-9401
Current Organisation
University of Nottingham
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Publisher: Frontiers Media SA
Date: 04-12-2017
Publisher: Frontiers Media SA
Date: 21-10-2015
Publisher: Wiley
Date: 04-08-2016
DOI: 10.1002/JCSM.12137
Publisher: American Physiological Society
Date: 07-2021
DOI: 10.1152/JAPPLPHYSIOL.00811.2020
Abstract: The data presented here suggest that metabolic responses to steady-state aerobic exercise are somewhat resistant to short-term changes in dietary carbohydrate (CHO) intake within the 5–6.5 g CHO·kg −1 ·day −1 [46–61% energy intake (EI)] range. In contrast, reduction in short-term dietary CHO intake to ∼2.4 g CHO·kg −1 ·day −1 (21% EI) evoked clear changes indicative of increased fat and decreased CHO metabolism during exercise.
Publisher: MDPI AG
Date: 26-12-2017
DOI: 10.3390/NU10010023
Publisher: Wiley
Date: 20-02-2019
Publisher: Elsevier BV
Date: 11-2020
DOI: 10.1093/AJCN/NQAA229
Publisher: Wiley
Date: 29-01-2021
DOI: 10.1113/JP280825
Publisher: American Physiological Society
Date: 07-2020
DOI: 10.1152/AJPCELL.00072.2020
Abstract: The role of dysregulated intracellular creatine (Cr) metabolism in disuse atrophy is unknown. In this study, skeletal muscle biopsy s les were obtained after 7 days of unilateral leg immobilization (IMMOB) and from the nonimmobilized control limb (CTRL) of 15 healthy men (23.1 ± 3.5 yr). S les were analyzed for fiber type cross-sectional area (CSA) and creatine transporter (CreaT) at the cell membrane periphery (MEM) or intracellular (INT) areas, via immunofluorescence microscopy. Creatine kinase (CK) and AMP-activated protein kinase (AMPK) were determined via immunoblot. Phosphocreatine (PCr), Cr, and ATP were measured via enzymatic analysis. Body composition and maximal isometric knee extensor strength were assessed before and after disuse. Leg strength and fat-free mass were reduced in IMMOB (~32% and 4%, respectively P 0.01 for both). Type II fiber CSA was smaller (~12% P = 0.028) and intramuscular PCr lower (~13% P = 0.015) in IMMOB vs. CTRL. CreaT protein was greater in type I fibers in both limbs ( P 0.01). CreaT was greater in IMMOB vs. CTRL ( P 0.01) and inversely associated with PCr concentration in both limbs ( P 0.05). MEM CreaT was greater than INT CreaT in type I and II fibers of both limbs (~14% for both P 0.01 for both). Type I fiber CreaT tended to be greater in IMMOB vs. CTRL ( P = 0.074). CK was greater and phospho-to-total AMPK Thr172 tended to be greater , in IMMOB vs. CTRL ( P = 0.013 and 0.051, respectively). These findings suggest that modulation of intracellular Cr metabolism is an adaptive response to immobilization in young healthy skeletal muscle.
Publisher: Wiley
Date: 07-09-2020
DOI: 10.1113/EP088795
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Sophie Joanisse.