ORCID Profile
0000-0002-1723-5047
Current Organisation
UNSW Sydney
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Publisher: American Chemical Society (ACS)
Date: 02-01-2020
Publisher: American Chemical Society (ACS)
Date: 09-10-2023
Publisher: American Chemical Society (ACS)
Date: 21-03-2022
DOI: 10.1021/ACS.NANOLETT.1C04469
Abstract: We have leveraged a high throughput approach to design a fully synthetic polymer mimic of the chemotherapeutic protein "TRAIL". Our design enables the synthesis of libraries of star-shaped polymers presenting exactly one receptor binding peptide at the end of each arm with no purification steps. Clear structure-activity relationships in screening for receptor binding and the apoptotic activity on colon cancer lines (COLO205) led us to identify trivalent structures, ∼1.5 nm in hydrodynamic radius as the best mimics. These showed IC
Publisher: American Chemical Society (ACS)
Date: 21-01-2022
DOI: 10.1021/ACS.BIOCONJCHEM.1C00536
Abstract: Preexisting serum albumin-polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this work, the noncovalent interaction of two polymers bearing fatty acid-based end-functionalities were compared and the superior binder was carried forward for testing with serum albumin that possessed a polymer conjugated to its Cys34 residue. The studies demonstrated that an albumin-polymer bioconjugate equipped with polymers via both covalent and supramolecular interactions can be successfully achieved.
Publisher: American Chemical Society (ACS)
Date: 19-11-2019
DOI: 10.1021/JACS.9B09899
Abstract: Structure-function relationships for multivalent polymer scaffolds are highly complex due to the wide ersity of architectures offered by such macromolecules. Evaluation of this landscape has traditionally been accomplished case-by-case due to the experimental difficulty associated with making these complex conjugates. Here, we introduce a simple dual-wavelength, two-step polymerize and click approach for making combinatorial conjugate libraries. It proceeds by incorporation of a polymerization friendly cyclopropenone-masked dibenzocyclooctyne into the side chain of linear polymers or the α-chain end of star polymers. Polymerizations are performed under visible light using an oxygen tolerant porphyrin-catalyzed photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) process, after which the deprotection and click reaction is triggered by UV light. Using this approach, we are able to precisely control the valency and position of ligands on a polymer scaffold in a manner conducive to high throughput synthesis.
Publisher: CSIRO Publishing
Date: 2020
DOI: 10.1071/CH19617
Publisher: American Chemical Society (ACS)
Date: 23-05-2023
No related grants have been discovered for Zihao Li.