ORCID Profile
0000-0002-6477-6030
Current Organisations
University of Porto
,
i3S - Instituto de Investigação e Inovação em Saúde & INEB-Instituto Nacional de Engenharia Biomédica
,
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar
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Publications
Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing
Publisher: Springer Science and Business Media LLC
Date: 09-05-2015
Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms
Publisher: Springer Science and Business Media LLC
Date: 10-01-2014
DOI: 10.1186/SCRT394
Adult Stem Cells and Biocompatible Scaffolds as Smart Drug Delivery Tools for Cardiac Tissue Repair
Publisher: Bentham Science Publishers Ltd.
Date: 08-2013
DOI: 10.2174/09298673113209990032
Abstract: The contribution of adult stem cells to cardiac repair is mostly ascribed to an indirect paracrine effect, rather than to their actual engraftment and differentiation into new contractile and vascular cells. This effect consists in a direct reduction of host cell death, promotion of neovascularization, and in a "bystander effect" on local inflammation. A number of cytokines secreted by adult stem rogenitor cells has been proposed to be responsible for the consistent beneficial effect reported in the early attempts to deliver different stem cell subsets to the injured myocardium. Aiming to maximize their beneficial activity on the diseased myocardium, the genetic modification of adult stem cells to enhance and/or control the secretion of specific cytokines would turn them into active drug delivery vectors. On the other hand, engineering biocompatible scaffolds as to release paracrine factors could result in multiple advantages: (1) achieve a local controlled release of the drug of interest, thus minimizing off-target effects, (2) enhance stem cell retention in the injured area and (3) boost the beneficial paracrine effects exerted by adult stem cells on the host tissue. In the present review, a critical overview of the state-of-the-art in the modification of stem cells and the functionalization of biocompatible scaffolds to deliver beneficial soluble factors to the injured myocardium is offered. Besides the number of concerns to be addressed before a clinical application can be foreseen for such concepts, this path could translate into the generation of active scaffolds as smart cell and drug delivery systems for cardiac repair.
Related Organisations
I3S - Instituto De Investigação E Inovação Em Saúde & INEB-Instituto Nacional De Engenharia Biomédica
Location: Portugal
Universidade Do Porto Instituto De Ciências Biomédicas Abel Salazar
Location: Portugal
Related Funding Activities
No related grants have been discovered for Perpetua Pinto-do-Ó.