ORCID Profile
0000-0002-8635-1199
Current Organisations
Max Delbrück Centrum für Molekulare Medizin Berlin Buch
,
Vanderbilt University Medical Center
,
University of Iowa
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Publisher: Springer Science and Business Media LLC
Date: 28-04-2008
DOI: 10.1038/NG.129
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 02-2011
Publisher: Elsevier BV
Date: 2011
DOI: 10.1016/J.NEURON.2010.12.028
Abstract: In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drinking water which may be mediated by peripheral osmoreceptors. Here, we identified afferent neurons in the thoracic dorsal root ganglia (DRG) of mice that innervate hepatic blood vessels and detect physiological hypo-osmotic shifts in blood osmolality. Hepatic sensory neurons are equipped with an inward current that faithfully transduces graded changes in osmolality within the physiological range (~15 mOsm). In mice lacking the osmotically activated ion channel, TRPV4, hepatic sensory neurons no longer exhibit osmosensitive inward currents and activation of peripheral osmoreceptors in vivo is abolished. We have thus identified a new population of sensory neurons that transduce ongoing changes in hepatic osmolality.
Publisher: Massachusetts Medical Society
Date: 02-01-2014
Publisher: Wiley
Date: 23-02-2021
DOI: 10.1111/APHA.13628
Location: United States of America
Location: United States of America
Location: Germany
Location: United States of America
No related grants have been discovered for Friedrich Luft.