ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0002-8635-1199

Current Organisations
Max Delbrück Centrum für Molekulare Medizin Berlin Buch , Vanderbilt University Medical Center , University of Iowa

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.

Publications

Publication

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease

Publisher: Springer Science and Business Media LLC

Date: 28-04-2008

DOI: 10.1038/NG.129

Publication

European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes

Publisher: Ovid Technologies (Wolters Kluwer Health)

Date: 02-2011

DOI: 10.1097/HJH.0B013E3283427C8B

Publication

The Molecular and Cellular Identity of Peripheral Osmoreceptors

Publisher: Elsevier BV

Date: 2011

DOI: 10.1016/J.NEURON.2010.12.028

Abstract: In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drinking water which may be mediated by peripheral osmoreceptors. Here, we identified afferent neurons in the thoracic dorsal root ganglia (DRG) of mice that innervate hepatic blood vessels and detect physiological hypo-osmotic shifts in blood osmolality. Hepatic sensory neurons are equipped with an inward current that faithfully transduces graded changes in osmolality within the physiological range (~15 mOsm). In mice lacking the osmotically activated ion channel, TRPV4, hepatic sensory neurons no longer exhibit osmosensitive inward currents and activation of peripheral osmoreceptors in vivo is abolished. We have thus identified a new population of sensory neurons that transduce ongoing changes in hepatic osmolality.

Publication