ORCID Profile
0000-0003-1981-7515
Current Organisation
Central Queensland University
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Publisher: Elsevier BV
Date: 12-2018
Publisher: Elsevier BV
Date: 2015
Publisher: Oxford University Press (OUP)
Date: 13-10-2019
DOI: 10.1111/JPHP.13184
Abstract: Dietary supplements are increasingly used by people with osteoarthritis. Boswellia serrata extract, curcumin, pine bark extract and methylsulfonylmethane have been identified as having the largest effects for symptomatic relief in a systematic review. It is important to understand whether any pharmacokinetic interactions are among the major constituents of these supplements so as to provide information when considering the combination use of these supplements. The aim of this study was to investigate the pharmacokinetics of the constituents alone and in combination. This study was a randomized, open-label, single-dose, four-treatment, four-period, crossover study with 1-week washout. The pharmacokinetics of the constituents of these supplements when dosed in combination with methylsulfonylmethane were compared to being administered alone. Plasma s les were obtained over 24 h from 16 healthy participants. Eight major constituents were analysed using a validated ultra-high-performance liquid chromatography–tandem mass spectrometry assay. The pharmacokinetics of each constituent was characterized, and there were no significant differences in the pharmacokinetic profiles of the constituents when administered as a combination, relative to the constituents when administered alone (P & 0.05). These data suggest that interactions between the major constituents of this supplement combination are unlikely and therefore could be investigated to manage patients with osteoarthritis without significant concerns for possible pharmacokinetic interactions.
Publisher: MDPI AG
Date: 13-11-2020
Abstract: Researchers in the resilience engineering space have proposed the notion that organisations operating in complex socio-technical systems cannot ‘be’ resilient but can have the ‘potential for resilient performance’. This theoretical stance also suggests that organisations wanting to enhance their potential for resilience begin by measuring their operational safety performance against four key potentials, these being: the Potential to Anticipate the Potential to Respond the Potential to Learn and the Potential to Monitor. Furthermore, to measure these four key resilience constructs, organisations have been recommended to use a Resilience Assessment Grid (RAG) developed as part of this theory. However, scarce research appears to have been conducted that bridges the theory and practice ide on just how organisations can pragmatically measure their current performance against these four resilience potentials using the RAG. Therefore, this research was interested in undertaking a pilot study using RAG theory in order to examine an organisation’s four resilience potentials, and was conducted within a large road transport organisation in Australia. Results indicated that measuring both the four in idual potentials and a combination of the four potentials was possible using a RAG and proved effective in providing a snapshot of operational safety system resilience concepts. Recommendations on how to increase organisational resilience potentials were provided to ensure future safety endeavours would enhance the organisation’s potential to be resilience in the face of system variability and operational demands.
Publisher: Springer International Publishing
Date: 23-06-2018
Publisher: Elsevier BV
Date: 06-2021
Publisher: Wiley
Date: 20-04-2021
DOI: 10.1111/NHS.12838
Abstract: Despite the important contribution of nongovernmental organizations (NGOs) to the community healthcare sector, the building and maintenance of occupational resilience in community health workers has received little attention. However, it is recognized that employees in this sector are exposed to significant stressors from the high demand work environment which negatively impacts on their well‐being. Therefore, this research examined the acceptability, feasibility, and sustainability of a mindful resiliency program by employing a qualitative analysis of participant subjective experience of the program in this cohort. This was the first study to be conducted with senior managers and frontline healthcare providers in the nongovernmental organizations community sector. A 1‐month post‐delivery qualitative review of the program identified four major themes: applicability, changes to participant's skills, social support, and coping with COVID‐19. A major finding was the ability of the participants to immediately recognize their stress levels and then manage them. Additionally, lessons from the program were shown to be usefully applied with colleagues and clients within the work environment, and with family members.
Publisher: Emerald
Date: 31-10-2019
DOI: 10.1108/IJES-08-2018-0041
Abstract: The purpose of this paper is to discuss the planning and use of an all-hazards emergency services approach to business disruption, which resulted from the hosting of the 2018 Commonwealth Games (GC2018) by Australia. It outlines how this emergency response model worked and how it can be transitioned into other operational areas. Although the Commonwealth Games provided a unique opportunity for Australia to showcase its large event capability, it also highlighted the need for innovation due to business disruption for front-line emergency response agencies. The Queensland Fire and Emergency Services (QFES) was faced with the need to review the standard emergency response model and to come up with a way to maintain business as usual operational effectiveness. An all-hazards approach to emergency response was ultimately achieved through expanded air operations (helicopters), the use of a multi-agency approach and the use of volunteers to achieve strategic risk management outcomes. The practical solutions that emerged are discussed as the expanded response model and collaborative engagements to achieve risk reduction, readiness and preparation. The solution to utilise an integrated emergency response methodology, including rapid and effective aerial support, reflected an all-hazards response to include deployment to road crash rescue, hazardous materials and structural fires. This business model ensured that QFES continued to meet its established “operational excellence” standards while pioneering options to address incident responses within the community wherein circumstances are considered exceptional.
Location: Australia
No related grants have been discovered for Karen Klockner.