ORCID Profile
0000-0002-6999-5507
Current Organisations
Royal College of Paediatrics and Child Health
,
University of Oxford
,
University of Cape Town Department of Medicine
,
Royal College of Physicians
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Publisher: Public Library of Science (PLoS)
Date: 15-01-2009
Publisher: American Medical Association (AMA)
Date: 09-08-2006
Publisher: Elsevier BV
Date: 08-2015
Publisher: Elsevier BV
Date: 09-2014
Publisher: Elsevier BV
Date: 11-2018
Publisher: Elsevier BV
Date: 12-2018
Publisher: SAGE Publications
Date: 27-10-2017
Abstract: A lack of research exists around the most common forms of sexual risk behaviors among adolescents, including their underlying factors, in Sub-Saharan Africa. Using an Ecological Model of Adolescent Behavior, we explore the perceptions of 85 young people and 10 stakeholders on sexual risk behavior of adolescents in Kilifi County on the coast of Kenya. Our findings show that transactional sex, early sexual debut, coerced sex, and multiple sexual partnerships are prevalent. An urgent need exists to develop measures to counter sexual risk behaviors. The results contribute to understanding the range of risks and protective factors in differing contexts, tackling underlying issues at in idual, family, local institutional, wider socio-economic, and political levels.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 23-04-2020
DOI: 10.1212/WNL.0000000000009632
Abstract: To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel coronavirus pandemic. The authors developed consensus statements in 2 sections. The first was “How should we/clinicians modify our clinical care pathway for people with epilepsy during the COVID-19 pandemic?” The second was “What general advice should we give to people with epilepsy during this crisis? The authors in idually scored statements on a scale of −10 (strongly disagree) to +10 (strongly agree). Five of 11 recommendations for physicians and 3/5 recommendations for in iduals/families were rated by all the authors as 7 or above (strongly agree) on the first round of rating. Subsequently, a teleconference was held where statements for which there was a lack of strong consensus were revised. After revision, all consensus recommendations received a score of 7 or above. The recommendations focus on administration of as much care as possible at home to keep people with epilepsy out of health care facilities, where they are likely to encounter COVID-19 (including strategies for rescue therapy), as well as minimization of risk of seizure exacerbation through adherence, and through ensuring a regular supply of medication. We also provide helpful links to additional helpful information for people with epilepsy and health providers. These recommendations may help health care professionals provide optimal care to people with epilepsy during the coronavirus pandemic.
Publisher: Elsevier BV
Date: 12-2012
Publisher: Wiley
Date: 29-08-2018
DOI: 10.1111/EPI.14496
Abstract: To describe the demographics, etiologies, types of status epilepticus (SE), and outcomes in people with refractory and super-refractory SE from around the world, we prospectively collected cases of refractory SE (RSE) treated with continuous intravenous anesthetic drugs in an intensive care unit setting through online questionnaires using "active surveillance." We collected information about 776 cases of RSE in 50 countries over 4 years. Control of SE was achieved in 74% of the cases. Neurologic outcomes were poor in 41% of patients, and 24% died. Good outcome was associated with younger age and a history of epilepsy. Etiology strongly influenced the outcome. Patients from Asia were younger, more frequently presented with convulsive SE, and were more frequently affected by infectious etiologies when compared with patients from Europe and the Americas. Despite these differences, outcomes were similar in all countries. Demographics of patients with RSE in a global audit are similar to those in prior single center series, providing evidence of generalizability of those studies. Important differences exist among patients with RSE from different regions of the world, but these do not seem to significantly influence patient outcomes.
Publisher: Elsevier BV
Date: 03-2013
Publisher: Elsevier BV
Date: 2015
Publisher: Oxford University Press (OUP)
Date: 29-04-2009
DOI: 10.1093/HMG/DDP192
Publisher: Elsevier BV
Date: 08-2015
DOI: 10.1016/J.YEBEH.2015.04.010
Abstract: The treatment of refractory and super refractory status epilepticus is a "terra incognita" from the point of view of evidence-based medicine. As randomized or controlled studies that are sufficiently powered are not feasible in relation to the many therapies and treatment approaches available, we carried out an online multinational audit (registry) in which neurologists or intensivists caring for patients with status epilepticus may prospectively enter patients who required general anesthesia to control the status epilepticus (SE). To date, 488 cases from 44 different countries have been collected. Most of the patients had no history of epilepsy and had a cryptogenic etiology. First-line treatment was delayed and not in line with current guidelines. The most widely used anesthetic of first choice was midazolam (59%), followed by propofol and barbiturates. Ketamine was used in most severe cases. Other therapies were administered in 35% of the cases, mainly steroids and immunotherapy. Seizure control was achieved in 74% of the patients. Twenty-two percent of patients died during treatment, and four percent had treatment actively withdrawn because of an anticipated poor outcome. The neurological outcome was good in 36% and poor in 39.3% of cases, while 25% died during hospitalization. Factors that positively influenced outcome were younger age, history of epilepsy, and low number of different anesthetics tried. This article is part of a Special Issue entitled "Status Epilepticus".
Publisher: Springer Science and Business Media LLC
Date: 30-09-2015
DOI: 10.1038/NATURE15390
Publisher: Elsevier BV
Date: 09-2014
Publisher: Public Library of Science (PLoS)
Date: 12-08-2015
Publisher: Wiley
Date: 23-07-2012
Publisher: Informa UK Limited
Date: 02-09-2013
Publisher: American Academy of Pediatrics (AAP)
Date: 17-06-2020
Publisher: Elsevier BV
Date: 04-2018
Publisher: SAGE Publications
Date: 26-06-2018
Abstract: Alcohol, tobacco, and other drug use form a risk factor for health and social problems during adolescence. From a socio-ecological model, perceptions of 85 young people and 10 stakeholders on the types of alcohol, tobacco, and other drugs used and the predisposing and protective factors were explored among adolescents at the Kenyan Coast in the Kilifi County. We found that the consumption of home-brewed alcohol, tobacco and marijuana smoking, and khat chewing was common and requires multi-component and community-centered intervention. Countering alcohol, tobacco, and other drug use needs enforcement of strong measures to regulate access to alcohol, tobacco, and other drugs for minors addressing social and cultural norms strategies for poverty alleviation and community empowerment.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: South Africa
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Charles Newton.