ORCID Profile
0000-0002-4556-0605
Current Organisations
Walter and Eliza Hall Institute of Medical Research
,
University of Queensland
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Publisher: Springer Science and Business Media LLC
Date: 07-06-2021
Publisher: Rockefeller University Press
Date: 29-05-2015
DOI: 10.1084/JEM.20181778
Abstract: Interleukin (IL)-17–producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and cancer. The factors that drive their development, in contrast to interferon (IFN)-γ–producing effector CD8+ T cells, are not clear. Here we demonstrate that the transcription factor TCF-1 (Tcf7) regulates CD8+ T cell fate decisions in double-positive (DP) thymocytes through the sequential suppression of MAF and RORγt, in parallel with TCF-1–driven modulation of chromatin state. Ablation of TCF-1 resulted in enhanced Tc17 cell development and exposed a gene set signature to drive tissue repair and lipid metabolism, which was distinct from other CD8+ T cell subsets. IL-17–producing CD8+ T cells isolated from healthy humans were also distinct from CD8+IL-17− T cells and enriched in pathways driven by MAF and RORγt. Overall, our study reveals how TCF-1 exerts central control of T cell differentiation in the thymus by normally repressing Tc17 differentiation and promoting an effector fate outcome.
Publisher: MDPI AG
Date: 02-2021
Abstract: Chronic inflammation of the gastrointestinal (GI) tract contributes to colorectal cancer (CRC) progression. While the role of adaptive T cells in CRC is now well established, the role of innate immune cells, specifically innate lymphoid cells (ILCs), is not well understood. To define the role of ILCs in CRC we employed complementary heterotopic and chemically-induced CRC mouse models. We discovered that ILCs were abundant in CRC tumours and contributed to anti-tumour immunity. We focused on ILC2 and showed that ILC2-deficient mice developed a higher tumour burden compared with littermate wild-type controls. We generated an ILC2 gene signature and using machine learning models revealed that CRC patients with a high intratumor ILC2 gene signature had a favourable clinical prognosis. Collectively, our results highlight a critical role for ILC2 in CRC, suggesting a potential new avenue to improve clinical outcomes through ILC2-agonist based therapeutic approaches.
Publisher: Frontiers Media SA
Date: 15-01-2019
Publisher: Elsevier BV
Date: 06-2019
DOI: 10.1016/J.COI.2019.04.008
Abstract: Adaptive and innate immune cells have typically been functionally and temporally segregated even though they share a number of salient features. Over the past decade, significant advances have been made in understanding the composition and ersity of both innate and adaptive cell populations. This has shed light on how cells from two distinct pathways are so highly complementary. Innate lymphoid cells (ILCs) are pivotally positioned in tissues to form a stable population akin to tissue-resident T cells that protects the body. Nevertheless, the pathway by which different lymphocytes enter tissues, terminally differentiate and are replenished to maintain populations remains incompletely understood. Recent evidence challenges our assumptions about the sedentary lifestyles of so called 'tissue-resident cells' and pushes us to consider their roles in orchestrating protection of the immune system beyond the classical models.
Publisher: Cold Spring Harbor Laboratory
Date: 2016
Abstract: Unlike clustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukemogenesis has not been extensively studied. Here we found that the hematopoietically expressed homeobox gene Hhex is overexpressed in acute myeloid leukemia (AML) and is essential for the initiation and propagation of MLL-ENL-induced AML but dispensable for normal myelopoiesis, indicating a specific requirement for Hhex for leukemic growth. Loss of Hhex leads to expression of the Cdkn2a -encoded tumor suppressors p16 INK4a and p19 ARF , which are required for growth arrest and myeloid differentiation following Hhex deletion. Mechanistically, we show that Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression. Thus, Hhex is a potential therapeutic target that is specifically required for AML stem cells to repress tumor suppressor pathways and enable continued self-renewal.
Publisher: Frontiers Media SA
Date: 16-11-2017
Publisher: Elsevier BV
Date: 04-2018
DOI: 10.1016/J.IMMUNI.2018.03.033
Abstract: Generation of functionally erse effector and memory killer T cells is essential for immediate and long-term protective immunity. Herndler-Brandstetter et al. (2018) report that Bach2 promotes functional plasticity of effector T cells and the transition into the long-term memory compartment by regulating the expression of the inhibitory receptor KLRG1.
Location: Australia
No related grants have been discovered for Qiutong Huang.