ORCID Profile
0000-0003-1746-7873
Current Organisation
KEMRI-Wellcome Trust Research Programme
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Publisher: Springer Science and Business Media LLC
Date: 30-09-2015
DOI: 10.1038/NATURE15390
Publisher: Elsevier BV
Date: 10-2015
Publisher: American Society of Tropical Medicine and Hygiene
Date: 07-2007
Publisher: Oxford University Press (OUP)
Date: 06-01-2016
Publisher: Springer Science and Business Media LLC
Date: 07-2019
Publisher: eLife Sciences Publications, Ltd
Date: 09-01-2017
DOI: 10.7554/ELIFE.15085
Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effect has proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report an analysis of multiple allelic forms of G6PD deficiency in a large multi-centre case-control study of severe malaria, using the WHO classification of G6PD mutations to estimate each in idual’s level of enzyme activity from their genotype. Aggregated across all genotypes, we find that increasing levels of G6PD deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia. Models of balancing selection based on these findings indicate that an evolutionary trade-off between different clinical outcomes of P. falciparum infection could have been a major cause of the high levels of G6PD polymorphism seen in human populations.
Publisher: Elsevier BV
Date: 08-2018
Publisher: Elsevier BV
Date: 10-2015
Location: United Kingdom of Great Britain and Northern Ireland
Location: Kenya
No related grants have been discovered for Sophie Uyoga.