ORCID Profile
0000-0002-1218-798X
Current Organisation
Norwegian Institute of Public Health
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Publisher: Wiley
Date: 14-04-2023
DOI: 10.1111/ACPS.13555
Abstract: Register‐based studies of major depressive disorder (MDD) do not capture all prevalent cases, as untreated cases and diagnoses made by general practitioners are not recorded in the registers. We examined the prevalence and agreement of survey‐ and register‐based measures of depression, and explored sociodemographic and health‐related factors that may have influenced this agreement. All 32,407 participants in the 2017 Central Denmark Region How are you? survey were linked to hospital and prescription records. A checklist for depressive symptoms within the last 14 days (Major Depression Inventory MDI) from the survey was compared with register‐based assessment of hospital‐diagnosed MDD and/or prescriptions for antidepressants. We estimated agreement between survey‐based and register‐based measures for depression and used logistic regression models to explore selected associated factors. In total, 5.9% of How are you? survey participants screened positive for current depression on the MDI. Of these, 51.3% (95% confidence interval (CI): 49.0–53.6) filled a prescription for an antidepressant medication during the 10 years prior or 2 years following the administration of the survey, and 14.5% (95% CI: 12.9–16.2) were treated for MDD in a psychiatric hospital‐based setting. When using a higher threshold of the MDI indicating more severe current depression, 22.8% (95% CI: 19.6–26.1) of those who screened positive also received an MDD diagnosis and 63.4% (95% CI: 59.7–67.2) were prescribed antidepressants during this 12‐year period. Among those with current depression, female sex, older age, chronic diseases, hospital‐treated self‐harm, and being permanently outside the workforce were associated with having a register‐based MDD diagnosis or antidepressant prescription. Among those with a register‐based depression record, female sex, younger age, hospital‐treated self‐harm, stress, and severe loneliness were associated with current depression. We found that as few as 15% of in iduals with current depression in the general Danish population were captured by the psychiatric hospital register, while 51% of these in iduals were identifiable in the prescription register. These findings demonstrate that register‐based measures significantly underestimate the true prevalence of depression by identifying only the cases that are most severe.
Publisher: Public Library of Science (PLoS)
Date: 17-01-2017
Publisher: BMJ
Date: 16-02-2017
DOI: 10.1136/ANNRHEUMDIS-2016-210146
Abstract: We used findings from the Global Burden of Disease Study 2013 to report the burden of musculoskeletal disorders in the Eastern Mediterranean Region (EMR). The burden of musculoskeletal disorders was calculated for the EMR's 22 countries between 1990 and 2013. A systematic analysis was performed on mortality and morbidity data to estimate prevalence, death, years of live lost, years lived with disability and disability-adjusted life years (DALYs). For musculoskeletal disorders, the crude DALYs rate per 100 000 increased from 1297.1 (95% uncertainty interval (UI) 924.3–1703.4) in 1990 to 1606.0 (95% UI 1141.2–2130.4) in 2013. During 1990–2013, the total DALYs of musculoskeletal disorders increased by 105.2% in the EMR compared with a 58.0% increase in the rest of the world. The burden of musculoskeletal disorders as a proportion of total DALYs increased from 2.4% (95% UI 1.7–3.0) in 1990 to 4.7% (95% UI 3.6–5.8) in 2013. The range of point prevalence (per 1000) among the EMR countries was 28.2–136.0 for low back pain, 27.3–49.7 for neck pain, 9.7–37.3 for osteoarthritis (OA), 0.6–2.2 for rheumatoid arthritis and 0.1–0.8 for gout. Low back pain and neck pain had the highest burden in EMR countries. This study shows a high burden of musculoskeletal disorders, with a faster increase in EMR compared with the rest of the world. The reasons for this faster increase need to be explored. Our findings call for incorporating prevention and control programmes that should include improving health data, addressing risk factors, providing evidence-based care and community programmes to increase awareness.
Publisher: BMJ
Date: 06-02-2019
DOI: 10.1136/BMJ.L94
Abstract: To use the estimates from the Global Burden of Disease Study 2016 to describe patterns of suicide mortality globally, regionally, and for 195 countries and territories by age, sex, and Socio-demographic index, and to describe temporal trends between 1990 and 2016. Systematic analysis. Crude and age standardised rates from suicide mortality and years of life lost were compared across regions and countries, and by age, sex, and Socio-demographic index (a composite measure of fertility, income, and education). The total number of deaths from suicide increased by 6.7% (95% uncertainty interval 0.4% to 15.6%) globally over the 27 year study period to 817 000 (762 000 to 884 000) deaths in 2016. However, the age standardised mortality rate for suicide decreased by 32.7% (27.2% to 36.6%) worldwide between 1990 and 2016, similar to the decline in the global age standardised mortality rate of 30.6%. Suicide was the leading cause of age standardised years of life lost in the Global Burden of Disease region of high income Asia Pacific and was among the top 10 leading causes in eastern Europe, central Europe, western Europe, central Asia, Australasia, southern Latin America, and high income North America. Rates for men were higher than for women across regions, countries, and age groups, except for the 15 to 19 age group. There was variation in the female to male ratio, with higher ratios at lower levels of Socio-demographic index. Women experienced greater decreases in mortality rates (49.0%, 95% uncertainty interval 42.6% to 54.6%) than men (23.8%, 15.6% to 32.7%). Age standardised mortality rates for suicide have greatly reduced since 1990, but suicide remains an important contributor to mortality worldwide. Suicide mortality was variable across locations, between sexes, and between age groups. Suicide prevention strategies can be targeted towards vulnerable populations if they are informed by variations in mortality rates.
Publisher: Elsevier BV
Date: 08-2015
Publisher: Elsevier BV
Date: 11-2018
Publisher: Elsevier BV
Date: 2015
Publisher: Elsevier BV
Date: 12-2018
No related grants have been discovered for Ann Kristin Knudsen.