ORCID Profile
0000-0003-4493-3446
Current Organisation
Coventry University
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Publisher: Emerald
Date: 27-05-2014
DOI: 10.1108/IJHMA-01-2013-0005
Abstract: – The purpose of this paper is to review sustainable planning literature and investigate a major development in an Australian regional city, looking for broad sustainable insights to improve urban growth management. – First, the authors sketched the backdrop to Ipswich and looked for the drivers propelling its rapid growth. They then generated a sustainability framework from the urban regeneration literature. In the empirical phase, they analysed a major development – the Icon project. They evaluated three of five regeneration domains using secondary sources, site observations and interviews with stakeholders and experts. – First, each city’s situation is unique, so the authors proffer no simplistic development formula. Internally, cities, including Ipswich, are spatially fragmented. Second, urban regeneration extends temporally and spatially beyond the project site boundaries or deadlines. Diminished property-driven regeneration neglects the social dimensions to sustainable housing or relegates it to an afterthought, but community participation is insufficient. Government needs to seed or drive (directly or via incentives) substantive social transformation. Projects supported with credible community social development are less risky, but, in competing for investment funds, local government can rush approve unsuitable projects. – The analysis focused on the planning and urban design aspects of the project. Only limited demographic, economic and social analyses were conducted, and the study would also benefit from interviews with a broader s le of experts. – Sustainable urban regeneration needs to consider not only the unique mix of regional growth drivers and constraints, but also specific local precinct characteristics. Intelligently configured community consultation should inform but not dilute design leadership. – This work investigates appropriate urban responses to growth pressure for sustainable outcomes in fast-growing regional cities.
Publisher: CAIRN
Date: 20-03-2023
Publisher: Center for Open Science
Date: 04-06-2020
Abstract: The Coronavirus pandemic has raised questions about public health system fragility or lack of health phronesis (practical wisdom). The UK is one of the unhealthiest developed nations on the planet with over 35% of its population projected to be obese by 2025. Notwithstanding, local sports infrastructure is patchy, raising the spectre of ‘accumulation by dispossession’. To investigate English obesity problem and its eu̯daemonic impediments the study ignored lines of inquiry involving confectionary vested interests. Instead, it focused on bathing amenities that, since antiquity, signal civilisation. The phronetic bathing health research involved five sequential phases. First, the health issue was identified (1) and then bathing facilities put into historical context (2a). A structured literature review of contemporary facilities and health associations (2b) provided the backdrop for subsequent nomothetical (3a-e) and idiographic investigations (4a-c). The mixed research strands were finally synthesised (5). Statistical analysis of English local area standardised mortality (2013-2017) found a significant association with pool sparsity, controlling for deprivation, obesity and other environmental factors (3a-b). Longitudinal time series modelling of English swimming pool construction data since the Victorian era found that, recently, it has become erratic and erges from its GDP and population growth fundamentals (3c-e). Idiosyncratically, the study considered three case studies, looking for qualitative insights (4). The closure of Bromley Lido in 1983 raises suspicions that short-termism or agency issues usurped public health phronesis (4a). In Cirencester, mistrust lingers about the privileged beneficiaries of local leisure service outsourcing (4b). An exemplary German pool complex in Ludenscheid illuminates comparative UK public bathing infrastructure deficiencies and intimates paradigm myopia or managerialist neglect (4c). Although the study is preliminary with acknowledged limitations, the literature reviews, nomothetic analyses and case studies impel phronetic deliberations to re-calibrate investment towards ecological public health and resilience in post-COVID ‘doughnut’ economy.
Publisher: Center for Open Science
Date: 28-12-2020
Abstract: Outlines reasons for French defeat during the Indochina War and artiulates contemporary strategic resilience metaphors. The French Indochina War (FIW) from 1946-1954 furnishes useful insights with resonance for current infectious, climatic, pollution, economic and security challenges. A structured analysis of the historical literature suggests that the French defeat in 1954 involved fundamental regime illegitimacy, political equivocation, intelligence shortcomings, strategic and operational failures but also the determination, strength and adaptability of the Việt Minh (VM). In 1945, France had re-occupied Vietnam to re-assert its global credentials. Later, Cold War logic and American aid sustained “La sale guerre”. However, the conflict merely delayed and bloodied an inevitable post-colonial regime shift. To maintain American aid flows yet retain French regional influence, the commander of the Expeditionary Corps, Henri Navarre, adopted an offensive stance. He sought to crush the VM, breathe life into the moribund French Union (L’Union française) and block Giáp’s feints on Laos. In November 1954, he inserted a fortified c at remote Diên Biên Phú (DBP). However, Navarre ignored the lessons of Hòa Bình (1950-51), Nghĩa Lộ (1951). He misread Nà Sản (1952) and underestimated VM capabilities. Operationally, the distance of DBP from Hanoi stretched the French aero-logistical system to its limits. Navarre also erted resources to sideshow – Opération Atlante. Giáp realised Navarre had taken the bait and sealed off the besieged c with five isions, including an artillery one. On 13th March, the VM attacked and conquered the garrison after 56 days on the evening of 7-8th May 1954. Navarre’s gamble had spectacularly backfired. Militarily, the French Expeditionary Corps might have recovered even considering the bloodbath at Mang Yang Pass almost seven weeks later. However, the psychological blow unmasked regime financial and political bankruptcy. Power drained away to the Americans or the communists. Whilst French Indochina perpetuated an iniquitous social structure, tainted by racism, symbolic and physical violence, it arguably it also protected minorities, spurned dictatorship and transferred culture and technology.The most striking finding that emerges from this investigation is the incredible transformation of the geography of Vietnam since 1948. Then, tigers and elephant roamed in jungles, 160km North West of Saigon, near Phan Thiết. Today, suburbia encroaches on depleted coffee plantations and desiccated scrub. Aside from concerns over the long-term ecological trajectories under anthropogenic pressures in ostensibly communist or capitalist inspired systems and, notwithstanding today’s very different context, the detailed investigation into aspects of the War provides strategic metaphors involving fiscal re-calibration, governance hierarchy or incentive regulations, hubristic corrections and ecological transformation.
Publisher: Science Publications
Date: 03-2013
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 12-2020
Publisher: Emerald
Date: 02-2013
DOI: 10.1108/14635781311292980
Abstract: The purpose of this paper is to investigate the limitations and potential usefulness of a “knowledge city” concept as ersification vehicle for property investors. The paper first dissects the “knowledge city” concept and then investigates whether it inoculates against economic turbulence as measured by growth and jobs recovery. The paper also looks at the protection offered by middle class population growth. The idea of the “knowledge city” comes from earlier economic constructs but concentrated at the urban scale. There are two versions – a technical and one enriched with institutional and social dimensions. The limited analysis of selective secondary data suggests that “knowledge city” and strong middle class population growth provide some protection from economic and, presumably, property market instability. Statistical limitations include arbitrary s le frames lack of data and unclear spatial resolution, short time frames for aggregate analysis. Further research requires, first, a structured grading of knowledge precincts and, second, randomised s ling of in idual properties to investigate any links between total risk‐adjusted performance is measured over a decade. To mitigate risk, investors should consider re‐weighting their portfolios to increase exposure to knowledge cities and second‐tier but fast growing cities in emerging countries. A knowledge‐city cannot be imposed by infrastructure, technology or place configuration alone. It involves multiple precinct configurations and subsidiarity. Institutions and people matter. A broader knowledge‐city conceptualisation helps inform planning, management and oversight for regional second‐tier cities. Dissecting, noting the limits and drawing out the practical implications of the “knowledge city” concept.
Publisher: Emerald
Date: 04-2014
DOI: 10.1108/JPIF-02-2014-0015
Abstract: – The paper aims to discuss the major and auxiliary types of cycles found in the literature. – The existence of cycles within economy and its sub-sectors has been studied for a number of years. In the wake of the recent cyclical downturn, interest in cycles has increased. To mitigate future risks, scholars and investors seek new insights for a better understanding of the cyclical phenomenon. The paper presents systematic review of the existing copious cyclical literature. It then discusses general characteristics and the key forces that produce these cycles. – The study finds four major and eight auxiliary cycles. It suggests that each cycle has its own distinct empirical periodicity and theoretical underpinnings. The longer the cycles are the greater controversy which surrounds them. – Cycles are monumental to a proper understanding of complex property market dynamics. Their existence implies that economies, whilst not deterministic, have a rhythm. Cyclical awareness can therefore advance property market participants. – The paper uncovers four major and eight auxiliary types of cycles and argues their importance.
Publisher: Elsevier BV
Date: 05-2018
DOI: 10.1016/J.MOLCEL.2018.03.005
Abstract: The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions. Here, we report the discovery of a family of vertebrate-specific PRC2.1 proteins, "PRC2 associated LCOR isoform 1" (PALI1) and PALI2, encoded by the LCOR and LCORL gene loci, respectively. PALI1 promotes PRC2 methyltransferase activity in vitro and in vivo and is essential for mouse development. Pali1 and Aebp2 define mutually exclusive, antagonistic PRC2 subtypes that exhibit ergent H3K27-tri-methylation activities. The balance of these PRC2.1/PRC2.2 activities is required for the appropriate regulation of polycomb target genes during differentiation. PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer.
Publisher: Elsevier BV
Date: 2020
DOI: 10.2139/SSRN.3619940
Publisher: Informa UK Limited
Date: 29-07-2014
Publisher: Elsevier BV
Date: 11-2015
Publisher: Center for Open Science
Date: 08-06-2022
Abstract: There seems to be a crisis in education and research. The education landscape looks fragmented, expensive and yet fails millions. A common perception is that, armed with cultural and social capital, the ‘sharp elbows of the middle classes’ game a commodified system to amass credentials. The media rails against learning institutions that inflate grades to cover up failings. Some academics game the system or churn out indigestible papers of negligible practical social impact. In an effort to unravel some of these issues and sketch the future of education and research, the study conducted a preliminary exploratory thematic investigation. First, it chose six credible institutions in the field. A brief review of associated web content chose prominent ‘sound bites’. In Phase II, the author identified relevant journal articles, using a focused rather than structured or systematic approach. Finally, in Phase III, the inquiry creatively and interactively grouped the collected secondary martial into themes, underpinned by reflection on decades of embedded teaching experience in a dozen schools or colleges and seven universities. The convenience s ling and judgemental analysis generated ten themes from recent seminal discourse on the future of education and research: TENSION PARADOX, ECOSYSTEM ENRICHMENT, PHRONESIS vs. COMMODIFICATION, ACCESS vs. ELITE CREDENTIALISATION, STRATEGIC COLLABORATION, NURTURING EMOTIONAL & SOCIAL WELLBEING, FUNDING/RECONFIGURING CAPITALISM, JUDICIOUS TECHNOLOGY, INVESTMENT IN PEOPLE, DEMOCRATISING DIALOGUE. The most salient dimensions were PHRONESIS vs. COMMODIFICATION and STRATEGIC COLLABORATION. In effect, much recent managerialist educational reform (notwithstanding its transformative gloss) seems, actually, fundamentally misguided. Second, impactful research in, for ex le, deep tech, resilience or health calls for strategic interdisciplinary collaboration.
Publisher: Emerald
Date: 29-08-2008
DOI: 10.1108/17538270810895079
Abstract: The purpose of this paper is to consider the impact of urban design master plan projects in the Australian context of Brisbane. It first reviewed the general ramifications of urban design projects on property markets. The local impacts of two major projects were then analysed and compared. A limited statistical analysis was conducted to investigate whether local price growth could be attributed to the projects or resulted from generally buoyant market conditions. The paper adopted a largely descriptive approach. It first reviewed the theoretical outcomes urban design projects should deliver. It then looked at the specific details of two distinct urban design projects in Brisbane and descriptively assessed their impact on adjacent local housing markets. It then compared relative aggregated location price growth to isolate discernable project price effects. Finally, the paper anecdotally selected some master designed properties and considered whether their prices were excessive compared to average location rents. The paper found conflicting evidence to support the view that urban design projects significantly lifted aggregated location prices. On the one hand, aggregated project location price growth was relatively muted. Other generic demand factors and local differences in housing stock quality sw ed project effects. On the other hand, at the in idual property level, there was some anecdotal evidence to suggest premiums were paid for urban designed homes. The paper indirectly suggests, then, that any price impacts of urban design projects are subject to rapid distance decay. The paper conducted only a limited historical review of revitalisation and urban design. A systematic in idual, project‐adjacent, property price analysis was not conducted. Rather, the aggregated dwelling price analysis and anecdotal rental review suggested, albeit inconclusively, that the effects of urban design are spatially restricted to the immediate vicinity of projects. Investors should note likely price impact of planned infrastructure projects is spatially restricted to the immediate environs of the project. The paper combines an overview of urban design and property market analysis.
Publisher: Emerald
Date: 22-02-2022
Abstract: Kuala Lumpur (KL) emerged as the capital of the newly independent Federation of Malayan States in 1957 with a population of 316,000. Over the next 60 years, the city expanded into a major urban regional conurbation. It now covers an area of 2,790 km 2 and has a population of around 7.7 million. In the last two decades, market-driven, fast-track development, underpinned by road infrastructure has accelerated the city's urban transformation. Especially over the last two decades, a spate of urban redevelopments, including commercial and retail complexes, specialised centres, industrial parks, educational complexes and residential estates have transformed the Kuala Lumpur Metropolitan Region (KLMR) beyond recognition. KL is only one ex le among many of intensive Southeast Asian property-led urban development, fuelled by demographic pressures and global capital inflows that transformed the regional natural and built environments. The purpose of this study is to investigate the influence of globalisation, neoliberalism and property-led development, on the built form and socio-cultural legacies of the KLMR. The major aim of this study is to determine how neoliberalism and property-led development have impacted the urban form and structure of the KLMR. The methodology applied in this study concentrates mainly on the use of qualitative research methods. The major qualitative research methods include qualitative analysis, field surveys and observations, primary and secondary data collection. The approach in this study is to exemplify the shift from government-sponsored development in the post-independence period to the current globalised-private oriented development. The major findings of this research suggest that the global, property-led mode of urban development, whilst superficially successful, undermined traditional and tropical-climate urban landscapes. It also bequeathed many urban or property level problems, including traffic congestion, air pollution, planning governance and building management issues. The paper outlines narratives for a more balanced and sustainable mode of urban development, which is more in tune with local culture and climatic conditions. This paper provides a deep insight analysis and evaluation of KL's growth from a small town into a global metropolitan region where property-led development dictates the rules and determines the character of the city.
Publisher: Elsevier BV
Date: 05-2023
Publisher: Informa UK Limited
Date: 10-11-2017
Publisher: Unpublished
Date: 2022
Publisher: Emerald
Date: 08-02-2011
DOI: 10.1108/14635781111100191
Abstract: The purpose of this paper is to develop a General Systems Theory (GST) risk management framework and conducts a preliminary investigation into its potential benefits. A risk management framework with four domains is developed by applying GST to property. Risk management in five listed Australian Real Estate Investment Trusts (A‐REITs) is benchmarked against the GST ideal using public web‐sites information. A‐REIT volatility‐adjusted returns are calculated using Treynor ratios for the year to May 2010. The link between risk management score and entity performance is then investigated. The GST framework directs attention to risks involving surveillance, capacity and controls. However, as predicted by the Efficient Market Hypothesis (EMH), the study found no link between assessed risk management and volatility‐moderated annual returns to May 2010. The risk scoring was predicated on publicly available data, with limited analysis of financial statements. The s le size was restricted. Successful entities are well governed, focused and innovative. Robust finances allow exploitation of emerging opportunity when business conditions become favourable. Planning and environmental management capabilities are essential. The paper makes conceptual and practical contributions. Conceptually, it develops a GST risk management framework. Practically, albeit for a handful of entities, the paper illustrates how the GST approach to risk management could be effectively deployed. The paper also outlines a pathway for more refined risk management research.
Publisher: Routledge
Date: 09-2017
Publisher: Emerald
Date: 03-07-2017
DOI: 10.1108/JPIF-10-2016-0083
Abstract: The purpose of this paper is to assess the duration of the UK commercial property cycles, their volatility and persistence to gauge future market direction. The study employs a novel approach to dissect cycles in a form of a three-step algorithm. First, the Hodrick-Prescott de-trends the selected variables. Second, volatility (measured by the variance) screens periods of atypical fluctuations in the series. Finally, the series is regressed against its past values to assess the level of persistence. The sequential steps screen the length of the cycles in UK commercial property market to facilitate interpretation. The estimates suggest that UK commercial property market follows an eight-year cycle. Combined modelling results indicate that the current market trend is likely to change over the coming year. The modelling suggests increasing probability of a market correction in late 2016/early 2017. This updated appreciation of the UK commercial property cycle duration allows for better market timing and investment decision making. The paper adds additional evidence on the contested issue of UK commercial property cycle duration.
Publisher: Informa UK Limited
Date: 2012
Publisher: Routledge
Date: 09-2017
Publisher: Informa UK Limited
Date: 2011
Publisher: Emerald
Date: 06-07-2015
DOI: 10.1108/JPIF-08-2014-0053
Abstract: – The commercial property market is complex, but the literature suggests that simple models can forecast it. To confirm the claim, the purpose of this paper is to assess a set of models to forecast UK commercial property market. – The employs five modelling techniques, including Autoregressive Integrated Moving Average (ARIMA), ARIMA with a vector of an explanatory variable(s) (ARIMAX), Simple Regression (SR), Multiple Regression, and Vector Autoregression (VAR) to model IPD UK All Property Rents Index. The Bank Rate, Construction Orders, Employment, Expenditure, FTSE AS Index, Gross Domestic Product (GDP), and Inflation are all explanatory variables selected for the research. – The modelling results confirm that increased model complexity does not necessarily yield greater forecasting accuracy. The analysis shows that although the more complex VAR specification is amongst the best fitting models, its accuracy in producing out-of-s le forecasts is poorer than of some less complex specifications. The average Theil’s U -value for VAR model is around 0.65, which is higher than that of less complex SR with Expenditure (0.176) or ARIMAX (3,0,3) with GDP (0.31) as an explanatory variable models. – The paper calls analysts to make forecasts more user-friendly, which are easy to use or understand, and for researchers to pay greater attention to the development and improvement of simpler forecasting techniques or simplification of more complex structures. – The paper addresses the issue of complexity in modelling commercial property market. It advocates for simplicity in modelling and forecasting.
Publisher: SAGE Publications
Date: 03-07-2015
Abstract: Despite a burgeoning literature, the role of bohemians in the urban milieu and in initiatives toward regeneration remains contested. As a first step toward later modeling and application, we present a thoroughgoing literature review, a short commentary on bohemian phenomena, and suggested readings. Since qualitative sources dominate the field, the review is structured rather than fully systematic in the scientific sense. After discarding innumerable irrelevant and incidental papers, three strands remained for subsequent analysis: “bohemian,” “bohemian + creative-city,” and “smart regeneration.” The first is static or historically contextualized, situated best in the humanities. The last two strands are dynamic and dissect, descriptively or analytically, elements of bohemianism relevant to the urban scene. Wherever and whenever they emerge, radical bohemian artists test existing limits or incite transformative action.
Publisher: Emerald
Date: 15-06-2015
Abstract: – The purpose of this paper is to sketch the UK housing backdrop, review the student private rented sector (PRS) and assess the experience of post-graduate university student tenants in the PRS. – A literature review puts the issues of student-PRS responsiveness into context and helps to untangle some UK housing issues. The private sector’s size, growth and performance is assessed by reviewing secondary data. In-depth interviews were then conducted at a regional university c us. – The study confirms accumulating evidence of an unbalanced UK housing market. The study identified four main PRS issues: first, rapid university expansion without accompanying residential construction has sparked r ant PRS growth with, second, quality issues, third, in tight letting market conditions, rented agent service levels fell and fourth, part of the problem is complex PRS management procedures. – The research has three noteworthy limitations. First, the macroeconomic analysis integrated secondary research without independent modelling. Second, the views of letting agents, university property managers, planning officers or landlords were not canvassed. Finally, the pilot interviews were geographically restricted. – When they expand, universities, local authorities and industry players need to give due consideration to plan for, design and develop quality student accommodation. Over-reliance on the PRS without informed oversight and coordination could undermine student experience and erode long-term UK competitiveness. – The lack of quality student rented accommodation mirrors a general housing malaise around affordability, polarisation and sustainable “dwelling”. Standards and professionalism in the rented sector is part of the overall quality mix to attract global talent. – The preliminary investigation uses mixed-methods to investigate PRS service delivery. It illustrates the interplay between professional property management and wider issues of metropolitan productivity, sustainability and resilience.
Publisher: Unpublished
Date: 2022
Publisher: MDPI AG
Date: 23-11-2019
Abstract: This research investigated the significance of learning dispositif (LD) and emotional attachment (EA) on perceived learning success (LS) across a diaspora of Western, Russian, Asian, Middle Eastern and Chinese student cohorts. Foucault’s LD captures the disparate socio-cultural contexts, institutional milieus and more or less didactic teaching styles that moderate learning. EA is a multi-dimensional notion involving affective bonds that emerged in child psychology and spread to marketing and other fields. The sequential explanatory research reviewed the learning and EA literatures and generated an LD–EA framework to structure the quantitative phase of its mixed investigations. In 2017 and 2018, the research collected 150 responses and used a range of statistical techniques for quantitative analysis. It found that LS varied significantly across cohorts, intimating that dispositifs influence learning. Nonparametric analysis suggested that EA also influenced learning, but regressions were inconclusive. Exploratory techniques hint at a dynamic mix of emotional or cognitive motivations during the student learning journey, involving structural breaks in student/instructor relationships. Cluster analysis identified distinct student groupings, linked to years of learning. Separately, qualitative analysis of open-ended survey questions and expert interviews intimates that frequent teacher interactions can increase EA. The synthesis of quantitative with qualitative results and pedagogical reflection suggests that LD and EA both influence learning in a complex, dynamic system. The key constituents for EA are Affection, Connection, Social Presence (SP), Teaching Presence (TP) and Flow but student emotional engagement is conditioned by the socio-cultural milieu (LD) and associated factors like relationships and trust. Unlike in the Community of Learning framework, in the EA framework Cognitive Presence (CP) is an outcome of the interaction between these EA constituents, associated factors and the socio-cultural milieu. Finally, whilst awareness of culture and emotions is a useful pedagogical consideration, learning mainstays remain inclusive educational systems that identify student needs and support well-designed programmes. Within these, scaffolded modules should include a variety of engaging learning activities with non-threatening formative and trustworthy summative feedback. We acknowledge some statistical study limitations, but its tentative findings make a useful preliminary contribution.
Publisher: Emerald
Date: 02-03-2015
DOI: 10.1108/IJHMA-04-2014-0010
Abstract: – This paper aims to investigate Lithuanian house price changes. Its twin motivations are the importance of information on future house price movements to sector stakeholders and the limited number of related Lithuanian property market studies. – The study employs ARIMA modelling approach. It assesses whether past is a good predictor of the future. It then examines issues relating to an application of this univariate time-series modelling technique in a forecasting context. – As the results of the study suggest, ARIMA is a useful technique to assess broad market price changes. Government and central bank can use ARIMA modelling approach to forecast national house price inflation. Developers can employ this methodology to drive successful house-building programme. Investor can incorporate forecasts from ARIMA models into investment strategy for timing purposes. – Certainly, there are number of limitations attached to this particular modelling approach. Firm predictions about house price movements are also a challenge, as well as more research needs to be done in establishing a dynamic interrelationship between macro variables and the Lithuanian housing market. – Although the research focused on Lithuania, the findings extend to global housing market. ARIMA house price modelling provides insights for a spectrum of stakeholders. The use of this modelling approach can be employed to improve monetary policy oversight, facilitate planning for infrastructure or social housing as a countercyclical policy and mitigate risk for investors. What is more, a greater appreciation of Lithuania housing market can act as a bellwether for real estate markets in other trade-exposed small country economies.
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.MOLCEL.2019.08.012
Abstract: Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27. At least two independent subcomplexes exist, defined by their specific accessory proteins: PRC2.1 (PCL1-3, EPOP, and PALI1/2) and PRC2.2 (AEBP2 and JARID2). We show that PRC2.1 and PRC2.2 share the majority of target genes in mouse embryonic stem cells. The loss of PCL1-3 is sufficient to evict PRC2.1 from Polycomb target genes but only leads to a partial reduction of PRC2.2 and H3K27me3. Conversely, disruption of PRC2.2 function through the loss of either JARID2 or RING1A/B is insufficient to completely disrupt targeting of SUZ12 by PCLs. Instead, the combined loss of both PRC2.1 and PRC2.2 is required, leading to the global mislocalization of SUZ12. This supports a model in which the specific accessory proteins within PRC2.1 and PRC2.2 cooperate to direct H3K27me3 via both synergistic and independent mechanisms.
Publisher: MDPI AG
Date: 28-06-2018
DOI: 10.3390/SU10072224
Location: United Kingdom of Great Britain and Northern Ireland
Location: No location found
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Simon Huston.