ORCID Profile
0000-0001-6011-2811
Current Organisations
UNSW
,
JSS Dental College and Hospital
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Publisher: World Wide Journals
Date: 2020
DOI: 10.36106/IJSR
Publisher: ACM
Date: 06-11-2012
Publisher: IEEE
Date: 12-2011
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2010
Publisher: ACM
Date: 16-04-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2016
Publisher: IEEE
Date: 05-2011
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: Elsevier BV
Date: 08-2022
Publisher: ACM
Date: 06-11-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: Elsevier BV
Date: 12-2015
Publisher: BMJ
Date: 07-2019
DOI: 10.1136/BMJOPEN-2019-030121
Abstract: Conflicting results from multiple randomised trials indicate that the methods and effects of blood pressure (BP) reduction after acute intracerebral haemorrhage (ICH) are complex. The Blood pressure in Acute Stroke Collaboration is an international collaboration, which aims to determine the optimal management of BP after acute stroke including ICH. A systematic review will be undertaken according to the Preferred Reporting Items for Systematic review and Meta-Analysis of In idual Participant Data (IPD) guideline. A search of Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception will be conducted to identify randomised controlled trials of BP management in adults with acute spontaneous (non-traumatic) ICH enrolled within the first 7 days of symptom onset. Authors of studies that meet the inclusion criteria will be invited to share their IPD. The primary outcome will be functional outcome according to the modified Rankin Scale. Safety outcomes will be early neurological deterioration, symptomatic hypotension and serious adverse events. Secondary outcomes will include death and neuroradiological and haemodynamic variables. Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient’s demographic, clinical and prestroke neuroradiological characteristics. No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted therefore, further ethical approval is not required. Results will be reported in international peer-reviewed journals. CRD42019141136.
No related grants have been discovered for Chandan S N.