ORCID Profile
0000-0001-7267-5136
Current Organisations
University of Nottingham
,
Karolinska Institutet
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Publisher: Elsevier BV
Date: 08-2019
Publisher: Elsevier BV
Date: 03-2021
Publisher: Elsevier BV
Date: 09-2017
DOI: 10.1038/GIM.2017.4
Publisher: MDPI AG
Date: 25-11-2020
DOI: 10.3390/JCM9123812
Abstract: Twin and adoption studies point towards a genetic contribution to tinnitus however, how the genetic risk applies to different forms of tinnitus is poorly understood. Here, we perform a familial aggregation study and determine the relative recurrence risk for tinnitus in siblings (λs). Four different Swedish studies (N = 186,598) were used to estimate the prevalence of self-reported bilateral, unilateral, constant, and severe tinnitus in the general population and we defined whether these 4 different forms of tinnitus segregate in families from the Swedish Tinnitus Outreach Project (STOP, N = 2305). We implemented a percentile bootstrap approach to provide accurate estimates and confidence intervals for λs. We reveal a significant λs for all types of tinnitus, the highest found being 7.27 (95% CI (5.56–9.07)) for severe tinnitus, with a higher susceptibility in women (10.25 95% CI (7.14–13.61)) than in men (5.03 95% CI (3.22–7.01)), suggesting that severity may be the most genetically influenced trait in tinnitus in a sex-dependent manner. Our findings strongly support the notion that genetic factors impact on the development of tinnitus, more so for severe tinnitus. These findings highlight the importance of considering tinnitus severity and sex in the design of large genetic studies to optimize diagnostic approaches and ultimately improve therapeutic interventions.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 03-2019
DOI: 10.1097/AUD.0000000000000614
Abstract: Research on the genetic basis of tinnitus is still in its first steps. A group of scientists dedicated to tinnitus genetics within European Tinnitus Network (TINNET) network recognize that further progress requires multicenter collaborative efforts for defining contributing genes. The purpose of the present work is to provide instructions regarding collection, processing, storage, and shipment of s les intended for genetic studies in auditory research. One part of the recommendations has a general character another part is of particular importance for auditory healthcare practitioners such as otolaryngology physicians, audiologists, and general practitioners. We provide a set of instructions and various options for obtaining s les. We give advice regarding s le processing, storage, and shipment and define the minimal and essential clinical information that should accompany the s les collected for genetic processing. These recommendations offer a basis to standardize and optimize collaborations between geneticists and healthcare practitioners specialized in tinnitus and hearing disorders.
Publisher: Elsevier BV
Date: 10-2020
Publisher: Cold Spring Harbor Laboratory
Date: 20-06-2022
DOI: 10.1101/2022.06.18.496668
Abstract: Tinnitus is a phantom sound perception affecting both auditory and limbic structures. The mechanisms of tinnitus remain unclear and it is debatable whether tinnitus alters attention to sound and the ability to inhibit repetitive sounds, a phenomenon also known as auditory gating. Here we investigate if noise exposure interferes with auditory gating and whether natural extracts of cannabis or nicotine could improve auditory pre-attentional processing in noise-exposed mice. We used 22 male C57BL/6J mice ided into noise-exposed (exposed to a 9-11 kHz narrow band noise for 1 hour) and sham (no sound during noise exposure) groups. Hearing thresholds were measured using auditory brainstem responses, and tinnitus-like behavior was assessed using Gap prepulse inhibition of acoustic startle. After noise exposure, mice were implanted with multi-electrodes in the dorsal hippoc us to assess auditory event-related potentials in response to paired clicks. The results showed that mice with tinnitus-like behavior displayed auditory gating of repetitive clicks, but with larger litudes and longer latencies of the N40 component of the aERP waveform. The combination of cannabis extract and nicotine improved auditory gating ratio in noise-exposed mice without permanent hearing threshold shifts. Lastly, the longer latency of the N40 component appears due to an increased sensitivity to cannabis extract in noise-exposed mice compared to sham mice. The study suggests that the altered central plasticity in tinnitus is more sensitive to the combined actions on the cholinergic and the endocannabinoid systems. Overall, the findings contribute to a better understanding of pharmacological modulation of auditory sensory gating.
Publisher: MDPI AG
Date: 28-07-2020
DOI: 10.3390/JCM9082412
Abstract: Many in iduals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18–90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n = 1388) or without (n = 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99–4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06–10.9), and THI ≥ 58 (OR 12.1, 95% CI 7.06–20.6). The association with THI ≥ 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68–14.2) for moderate and 77.4 (95% CI 35.0–171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.
Publisher: Springer Science and Business Media LLC
Date: 22-05-2020
DOI: 10.1038/S41598-020-65395-1
Abstract: The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48 OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58 OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity.
Publisher: Elsevier BV
Date: 10-2020
Publisher: American Medical Association (AMA)
Date: 07-2019
Publisher: Elsevier BV
Date: 10-2020
Publisher: Elsevier BV
Date: 03-2020
Publisher: Frontiers Media SA
Date: 04-09-2017
Publisher: Elsevier BV
Date: 10-2020
Publisher: Elsevier BV
Date: 06-2019
DOI: 10.1016/J.HEARES.2019.02.017
Abstract: The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have h ered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced the Tinnitus S le Case History Questionnaire, a case history instrument for standardised collection of information about the characteristics of the tinnitus patient. Since then, a number of studies have been published which characterise in iduals and groups using data collected with this questionnaire. However, its use has been restricted to a clinical setting and to the evaluation of people with tinnitus only. In addition, it is limited in the ability to capture relevant comorbidities and evaluate their temporal relationship with tinnitus. Here we present a new case history instrument which is comprehensive in scope and can be answered by people with and without tinnitus alike. This 'European School for Interdisciplinary Tinnitus Research Screening Questionnaire' (ESIT-SQ) was developed with specific attention to questions about potential risk factors for tinnitus (including demographics, lifestyle, general medical and otological histories), and tinnitus characteristics (including perceptual characteristics, modulating factors, and associations with co-existing conditions). It was first developed in English, then translated into Dutch, German, Italian, Polish, Spanish, and Swedish, thus having broad applicability and supporting international collaboration. With respect to better understanding tinnitus profiles, we anticipate the ESIT-SQ to be a starting point for comprehensive multi-variate analyses of tinnitus. Data collected with the ESIT-SQ can allow establishment of patterns that distinguish tinnitus from non-tinnitus, and definition of common sets of tinnitus characteristics which might be indicated by the presence of otological or comorbid systemic diseases for which tinnitus is a known symptom.
Publisher: Frontiers Media SA
Date: 19-03-2019
Publisher: Elsevier
Date: 2021
Publisher: Elsevier BV
Date: 10-2020
Publisher: Cold Spring Harbor Laboratory
Date: 14-03-2023
DOI: 10.1101/2023.03.14.532543
Abstract: Psychiatric disorders, such as schizophrenia, are complex and challenging to study, partly due to the lack of suitable animal models. However, the absence of the Slc10a4 gene, which codes for a monoaminergic and cholinergic associated vesicular transporter protein, in knockout mice ( Slc10a4 -/- ), leads to the accumulation of extracellular dopamine. This makes them a potential animal model for schizophrenia, a disorder known to be associated with altered dopamine signaling in the brain. The locomotion, auditory sensory filtering and prepulse inhibition (PPI) of Slc10a4 -/- mice were quantified and compared to wildtype (WT) littermates. Intrahippoc al electrodes were used to record auditory event-related potentials (aERPs) for quantifying sensory filtering in response to paired-clicks. The channel above aERPs phase reversal was chosen for reliably comparing results between animals, and aERPs litude and latency of click responses were quantified. WT and Slc10a4 -/- mice were also administered subanesthetic doses of ketamine to provoke psychomimetic behavior. Baseline locomotion during auditory stimulation was similar between Slc10a4 -/- mice and WT littermates. In WT animals, normal auditory gating was observed after i.p saline injections, and it was maintained under the influence of 5 mg/kg ketamine, but disrupted by 20 mg/kg ketamine. On the other hand, Slc10a4 -/- mice did not show significant differences between N40 S1 and S2 litude responses in saline or low dose ketamine treatment. Auditory gating was considered preserved since the second N40 peak was consistently suppressed, but with increased latency. The P80 component showed higher litude, with shorter S2 latency under saline and 5 mg/kg ketamine treatment in Slc10a4 -/- mice, which was not observed in WT littermates. Prepulse inhibition was also decreased in Slc10a4 -/- mice when the longer interstimulus interval of 100 ms was applied, compared to WT littermates. The Slc10a4 -/- mice responses indicate that cholinergic and monoaminergic systems participate in the PPI magnitude, in the temporal coding (response latency) of the auditory sensory gating component N40, and in the litude of aERPs P80 component. These results suggest that Slc10a4 -/- mice can be considered as potential models for neuropsychiatric conditions.
Publisher: Elsevier
Date: 2021
Publisher: Frontiers Media SA
Date: 19-08-2016
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Christopher R. Cederroth.