ORCID Profile
0009-0002-5078-6622
Current Organisations
IEEE Women in Engineering
,
Canterbury Institute of Management
,
Robogals, University of Melbourne
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Publisher: Elsevier BV
Date: 05-2021
Publisher: Elsevier BV
Date: 04-2019
DOI: 10.1016/J.SAA.2019.01.030
Abstract: Metallic silver nanowires with high yield were synthesized using a modified seed mediated approach at room temperature. Ribbon-like nanostructures were obtained when the concentration of NaOH was lower and further increase of NaOH transformed it into long nanowires. These nanowires possess high aspect ratio, with length and diameter ~6.5 μm and 17 nm respectively. The surface enhanced Raman scattering activity of these nanowires was tested with three different probe molecules viz., crystal violet, malachite green and nile blue chloride using visible (514.4 nm) and near-infrared (784.8 nm) excitation lines. The minimum detection limits for crystal violet and nile blue chloride molecules were found to be down to 10
Publisher: Oxford University Press (OUP)
Date: 14-04-2020
DOI: 10.1017/S1431927620001403
Abstract: This study tests the use of a constrained nonnegative matrix factorization (NMF) algorithm to explore the comparatively new field of chemometric microscopy to support tissue diagnosis. The algorithm can extract the spectral signature and the absolute concentration map of endogenous fluorophores from wide-field microscopic images. The resultant data distinguished normal and fibrous calvarial tissues, based on the changes in their spectral signatures. The absolute concentration map of endogenous fluorophores, nicotinamide adenine dinucleotide (NADH), flavin adenine dinucleotide (FAD), and lipofuscin were derived from microscopic images and compared with the fluorescence from pure fluorophores. While the absolute concentration of NADH increased, the same of FAD and lipofuscin decreased from a normal to fibrous calvarial condition. An increase in the optical redox ratio, possibly due to the metabolic changes during the development of fibrosis, was observed. Differentiating tissue types using the absolute concentration map was found to be considerably more precise than that achievable with relative concentration. The quantification of fluorophores with reference to the absolute concentration map can eliminate uncertainties due to system responses or measurement details, thereby generating more biologically apposite data. Wide-field microscopy augmented with a constrained NMF algorithm could emerge as an advanced diagnostic tool, potentially heralding the emergence of chemometric microscopy.
Publisher: Elsevier BV
Date: 11-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2TB02802F
Abstract: l -Dopa conjugated cysteine-gold nanoclusters (AuCs-LD) can cross the blood–brain barrier and disintegrate Aβ plaques, demonstrating a potential therapeutic for the management of Alzheimer's disease.
Publisher: Wiley
Date: 21-09-2018
Publisher: Elsevier BV
Date: 06-2018
Publisher: Wiley
Date: 28-01-2020
Abstract: Strong plasmon absorption in the near‐infrared (NIR) region renders gold nanorods (GNRs) amenable for biomedical applications, particularly for photothermal therapy. However, these nanostructures have not been explored for their imaging potential because of their weak emission profile. In this study, the weak fluorescence emission of GNRs is tuned to match that of the absorption of a photosensitizer (PS) molecule, and energy transfer from the GNR to PS enhances the emission profile of the GNR–PS combination. GNR complexes generally quench the fluorescence emission of nearby chromophores. However, herein, the complex retains or rather enhances the fluorescence through competition in energy transfer. Excitation‐dependent energy transfer has been explained experimentally and theoretically by using DFT calculations, the CIE chromaticity diagram, and power spectrum. The final GNR–PS complex modified for tumor specificity serves as an excellent organ‐specific theranostic probe for bioimaging and dual therapy both in vitro and in vivo. Principal component analysis designates photodynamic therapy a better candidate than that of photothermal therapy for long‐term efficacy in vivo.
Publisher: Elsevier BV
Date: 09-2018
Location: India
No related grants have been discovered for Rekha C R.