ORCID Profile
0000-0003-2307-6035
Current Organisation
Northern Ontario School of Medicine
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Publisher: Wiley
Date: 08-2018
DOI: 10.1002/DVDY.24639
Publisher: Elsevier
Date: 2020
Publisher: Wiley
Date: 04-09-2013
DOI: 10.1096/FJ.13-227967
Publisher: Wiley
Date: 15-02-2018
Publisher: Wiley
Date: 16-02-2017
DOI: 10.1002/WDEV.264
Abstract: Vitamin A and its active metabolite retinoic acid are essential for embryonic development and adult homeostasis. Surprisingly, excess or deficiency of vitamin A and retinoic acid can cause similar developmental defects. Therefore, strict feedback and other mechanisms exist to regulate the levels of retinoic acid within a narrow physiological range. The oxidation of vitamin A to retinal has recently been established as a critical nodal point in the synthesis of retinoic acid, and over the past decade, RDH10 and DHRS3 have emerged as the predominant enzymes that regulate this reversible reaction. Together they form a codependent complex that facilitates negative feedback maintenance of retinoic acid levels and thus guard against the effects of dysregulated vitamin A metabolism and retinoic acid synthesis. This review focuses on advances in our understanding of the roles of Rdh10 and Dhrs3 and their impact on development and disease. WIREs Dev Biol 2017, 6:e264. doi: 10.1002/wdev.264 This article is categorized under: Signaling Pathways Global Signaling Mechanisms Birth Defects Craniofacial and Nervous System Anomalies Birth Defects Organ Anomalies
Location: United States of America
Location: United States of America
No related grants have been discovered for Alexander Moise.